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Despite the fact that caring has been regarded as the core of nursing for decades, our knowledge about caring is still mainly on a philosophical level. The problem with these philosophical descriptions is that they do not serve as explicit guides for today's nurses, particularly in the light of the considerable changes that have taken place in the healthcare sector. One of the aims of this thesis

Hematopoietic stem cells (HSC), the ancestors of all blood cells, have the ability to give rise to mature effector cells through a series of developmental steps. This is a tightly regulated, though a highly dynamic process: on the one hand, dysregulation in steady-state could lead to under- or overgrowth of certain blood cell lineages, whereas, on the other hand, demands for certain mature blood c

Intramolecular motions of proteins are critical for biological function. Transient structural fluctuations underlie a wide range of processes, including enzyme catalysis, ligand binding to buried sites, and generic protein motions, such as 180 degrees rotation of aromatic side chains in the protein interior, but remain poorly understood. Understanding the dynamics and molecular nature of concerted

The Murray Basin is a low-lying but extensive intracratonic depocentre in southeastern Australia, preserving an extraordinary record of Late Neogene sedimentation. New stratigraphic and sedimento-logic data allow the long-term evolution of the basin to be re-evaluated and suggest a significant role for: (1) tectonism in controlling basin evolution, and (2) progressive and step-wise climatic change

Today, as a rule, the most cost-effective way to remove nitrogen from municipal wastewater is the biological method based on nitrification and subsequent denitrification. All biological systems may be affected by toxicants, and biological nitrogen removal is no exception. An investigation of influent wastewaters from 109 Swedish municipal wastewater treatment plants was accomplished. Inhibitory s

Popular Abstract in German Spannungsgesteuerte Kalziumkanäle haben eine große Bedeutung in vielen elektrisch erregbaren Zellen, wie z.B. in Nervenzellen und pankreatischen beta-Zellen. Hier werden sie folgendermaßen aktiviert: In der Nahrung enthaltener Traubenzucker (Glukose) wird nach einer Mahlzeit über den Blutstrom im Körper verteilt und in die beta-Zellen über Glukosetransporter aufgenommen.Voltage-gated Ca2+ channels are essential transducers of cellular signals in many electrically excitable cells. In the pancreatic beta-cell they mediate controlled Ca2+ influx, which is the final trigger for Ca2+ dependent release (exocytosis) of the blood glucose lowering hormone insulin. Several subtypes of voltage-gated Ca2+ channels are known and the L-type has been found to be the main contri

Baylor and collaborators have demonstrated (Baylor & Plant, 2005; Baylor et. al., 2006) that the use of virtual pedagogical coaches portrayed as young and attractive women can increase the willingness of female students to apply for technical education and to help increase their selfefficacy. Pedagogical processes such as role modelling and identification seem to be involved (cf. Bandura, 1977

The incidence of Diabetes Mellitus increases globally in epidemic proportions. Type 2 Diabetes is the most prevalent form of Diabetes, comprising 90% of the patients. In Type 2 Diabetes, two processes contribute to the development of the disease: insufficient insulin secretion from the pancreatic ?-cell and insulin resistance of the target organs. This leads to loss of control of blood glucose lev

State formation in Europe and, more precisely, the nature and development of the early modern type of state, is the focus of this book. The study of state formation has, in recent years, been heavily influenced by the works of Charles Tilly and his followers, who stress international military competition as the driving force in the development of the European states and state system, creating stro

Popular Abstract in Swedish En av de stora vetenskapliga bedrifterna hittills under 2000-talet är onekligen att man efter många års arbete för första gången lyckades kartlägga (sekvensera) samtliga mänskliga gener. Det mänskliga DNA:t är lokaliserat till cellkärnan och i princip så kan man likna en cellkärna med ett kontrollrum fyllt av manualer (DNA) som talar om cellens sammansättning och hur deProteomics is expected to generate new insights into biological processes as well as identify novel biomarkers and therapeutic targets since most biological functions are transmitted through proteins. However, due to the complexity displayed by a proteome and inherent limitations associated with current methodologies, proteomic analyses often result in incomplete coverage and inconsistent measurem

Popular Abstract in Swedish Mer än 75 % av energianvändningen i världen kommer idag från förbränning av fossila bränslen, biobränslen och avfall. Trots att alternativa energikällor är på framfart kommer förbränning stå för den största andelen av världens energianvändning även de kommande decennierna. Tyvärr medför förbränning flera negativa konsekvenser, såsom ökad koldioxidhalt i atmosfären och uLaser-induced incandescence, LII, is a laser-diagnostic technique that can be used to measure the volume fraction and the sizes of soot particles suspended in a gas, such as within a combustion process or in its exhausts. The technique is based on the facts that the time-decay of the radiation from laser-heated soot particles is directly related to the particle size in the probed volume, and that

Acute myeloid leukemia (AML) is a highly heterogeneous blood disease which is characterized by different mutations and chromosomal rearrangements. Nearly 60% of genetic alterations have been found in AML patients involve in signaling pathways including signaling of tyrosine kinase receptor FLT3. FLT3 mutations emerged as one of the most common mutations in AML which represent around 35% of all AML

Inflammatory airway diseases and lower respiratory tract infections are leading causes of severe illness, disability and death worldwide. Much of today´s hypotheses about the underlying inflammatory processes and pathogenic contribution by immune cells come from in vitro experiments or animal models. As a consequence, our knowledge of the actual immunopathological events in real patient tissues is

In the domain of current spatial semiotics two important, but also radically different, approaches can be distinguished as modelling the co-operative agency of human, material and legal properties of space, namely that of Manar Hammad’s and that of Bruno Latour’s. Hammad, being a semiotician, more true to the Greimasian heritage, regards a finite set of principal actantial types (owners, visitors,

Popular Abstract in Swedish Industrin i Sverige och i många andra länder står för en stor del av samhällets energianvändning och energi utgör en nödvändig insats i industrins processer och förädling av produkter. Industriell tillverkning sysselsätter dessutom många arbetstagare både direkt och indirekt i utbytet med övriga delar av samhället och ekonomin. Samtidigt medför energianvändning och relaAt EU and to a varying degree at Member State (MS) level, industrial energy efficiency improvement (EEI) is considered an attractive means for reaching political objectives of different dimensions, not least environmental. For energy-intensive manufacturing industry in particular, EEI can lead to cost reductions, improved profitability and competitiveness. However, research and other analyses show

The thesis comprises an analysis of the heat transfer phenomenon in solid oxide fuel cells (SOFCs) and a description of various transport phenomena in a solid oxide electrolysis cell. Both devices are encompassed under the solid oxide electrochemical cell concept. Moreover, a CFD model of an SOEC was developed to study the behavior of the cell under different conditions of operating and structural

Background: Subjective Well-Being (SWB) is usually conceptualized in terms of an affective (i.e., judgements of biological emotional reactions and experiences) and a cognitive component (i.e., judgements of life satisfaction in relation to a psychological self-imposed ideal). Recently, researchers have suggested that judgements of harmony in life can replace or at least complement the cognitive co

In this thesis, we investigate and develop new methods for efficient and functional use of resources in edge networks. Setting this work aside from previous work, we study User Generated Content (UGC) such as social media information and data generated in the new emerging Internet of Things systems. We present efficient solutions for placing such content and managing which network resources should

Land-use and land-cover (LUC) changes are a key uncertainty when attributing changes in measured atmospheric CO2 concentration to its sinks and sources and must also be much better understood to determine the possibilities for land-based climate change mitigation, especially in the light of human demand on other land-based resources. On the spatial scale typically used in terrestrial ecosystem mod