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The sialyl Lewis x (SLex) tetrasaccharide is the smallest recognizable ligand for selectins. The selectins constitute a vital part of the inflammatory cascade for recruitment of leukocytes to a site of tissue damage or microbial infection. If too many leukocytes are recruited, normal, not injured, cells can be damaged; a process known from chronic inflammatory diseases such as reumatoid arthritis,
Formulating and implementing a new strategy may be a challenging task, especially if it alters the way in which a company has operated and positioned itself before. This may be particularly true for companies within the forest industry, like manufacturers of paper packaging products, pursuing differentiated customer value and innovative solutions where, traditionally, success has been measured in
e concept of ecosystem services was originally developed to illustrate the benefits that natural ecosystems generate for society and to raise awareness for biodiversity and ecosystem conservation. In this article we identify major challenges and opportunities for ecologists involved in empirical or modeling ecosystem service research. The first challenge arises from the fact that the ecosystem ser
A new influenza virus that was first detected in people in April 2009, was initially referred to colloquially as "swine flu", since it contained genes from swine, avian and human influenza viruses. It can, however, not be transmitted by eating pork or dealing with pigs. In Egypt, several hundred thousand pigs were killed in May, in spite of advice from global health authorities that such an action
Popular Abstract in Swedish Inom forskningsområdet biogeokemi studerar man hur naturens olika grundämnen, såsom kol, kväve, fosfor och kisel ändrar form och transporteras genom landskapet för att via bäckar och vattendrag till slut nå havet. Tillsammans beskriver dessa olika processer, som sker på olika tidsskalor, från sekunder till flera miljoner år, ett grundämnes kretslopp (eller biogeokemiskaSilicon is the next most abundant element in the Earth’s crust and its biogeochemical cycle is linked with that of carbon. Further, silicon is a beneficial nutrient for plants in terrestrial ecosystems and a key nutrient for diatoms in aquatic ecosystems. During the last decade the important role of terrestrial vegetation in controlling Si fluxes downstream aquatic environments, via incorporation
The studies described in this thesis focus on the involvement of the two laminin G-type domains of vitamin K-dependent protein S in various biological contexts. The G-type domains are located in the C-terminal sex-hormone-binding globulin (SHBG)-like region. In human plasma, the majority of protein S circulates in a high-affinity complex with the complement regulatory protein C4b-binding protein (
Vitreoscilla is an obligate aerobic bacterium found in oxygen-poor environments such as stagnant ponds and decaying vegetable matter. Vitreoscilla induces the production of a homodimeric hemoglobin (VHb) when subjected to oxygen-limiting conditions. It is thought that VHb facilitates oxygen delivery to the respiratory apparatus of its host by increasing the local oxygen concentration under oxygen-
Plant cells have two main modes of growth generating anisotropic structures. Diffuse growth where whole cell walls extend in specific directions, guided by anisotropically positioned cellulose fibers, and tip growth, with inhomogeneous addition of new cell wall material at the tip of the structure. Cells are known to regulate these processes via molecular signals and the cytoskeleton. Mechanical s
Cadmium-enrichment of farmland soil greatly threatens the sustainable use of soil resources and the safe cultivation of grain. This review paper briefly introduces the status of farmland soil as well as grain, which are both often polluted by cadmium (Cd) in China, and illustrates the major sources of Cd contaminants in farmland soil. In order to meet soil environmental quality standards and farml
European rivers experience increased loading of total organic carbon (TOC) from terrestrial sources due to factors involving changes in land use, climate and soil acidity. However, little is known about how increased TOC is linked to changes in the bioreactivity of organic matter in these rivers on a continental scale. We compiled paired measurements of TOC and biological oxygen demand in 5‐day 20
General introduction This publication is the end product of the Invisible Girl project, an international, Swedishbased and multidisciplinary research project in which the interplay of power relations, gender, and age was the primary object of study. The project was global in its scope and included researchers and artists from Australia, Canada, Croatia, The Czech Republic, Estonia, India, Israel
The demands on library services are quickly changing in a continually updating digital age. This increases the importance of a good understanding of the needs and demands of the users. In order to sample and follow the change in user needs library organisations analyse their efforts using a series of different methods. In a recent survey distributed to all 301 European LIBER university libraries,
Tissue factor (TF) expressed at the protein level includes two isoforms: The membrane‑bound full‑length TF (flTF) and the soluble alternatively spliced TF (asTF). flTF is the major thrombogenic form of TF, whereas asTF is more closely associated with tumor growth, angiogenesis, metastasis and cell growth. In order to further investigate the different expression and functions of TF splice variants,
Accurate quantitation of activity provides the basis for internal dosimetry of targeted radionuclide therapies. This study investigated quantitative imaging capabilities at sites with a variety of experience and equipment and assessed levels of errors in activity quantitation in Single-Photon Emission Computed Tomography (SPECT) and planar imaging. Participants from 9 countries took part in a comp
Frequent land-use changes in urban areas require an efficient and dynamic approach to reform and update detailed plans by re-arrangement of surrounding land-uses in case of change in one or several urban land-uses. However, re-arrangement of land-uses is problematic, since a variety of conflicting criteria must be considered and satisfied. This paper proposes and examines a two-step approach to re
Evacuation planning is an important activity in disaster management to reduce the effects of disasters on urban communities. It is regarded as a multi-objective optimization problem that involves conflicting spatial objectives and constraints in a decision-making process. Such problems are difficult to solve by traditional methods. However, metaheuristics methods have been shown to be proper solut
This paper exposes and problematises the situation of children and adolescents with (dis)abilities in relation to Sweden’s Art and Music Schools during the time period of a national policy process.Many researchers in the Nordic countries have raised aspects of democracy in music education, as a path toward the inclusion of all children. The inclusion of children and adolescents with (dis)abilities
Calbindin D9k exhibits cooperative binding of two calcium ions, hence study of the half-saturated states of the protein is critical to understanding the binding process. However, the half-saturated states are not significantly populated under equilibrium conditions. To circumvent this problem, an absolutely conserved glutamic acid residue in the C-terminal binding site (site II) has been mutated t
NOx pollution from Diesel engines causes over 10 000 premature deaths annually and the trend is increasing. In order to decrease this growing global problem, exhaust after-treatment systems for Diesel engines have to be improved. The most common SCR systems in the market place inject an aqueous Urea solution, DEF that evaporates prior the catalytic surface of the SCR-catalyst. Due to a catalytic r
