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The endoplasmic reticulum (ER) structure is of central importance for the regulation of cellular anabolism, stress response, and signal transduction. Generally continuous, the ER can temporarily undergo dramatic structural rearrangements resulting in a fragmented appearance. In this study we assess the dynamic nature of ER fission in pyramidal neurons in organotypic hippocampal slice cultures stim
Background: In obese patients, jejunoileal bypass (JIB) has been used to induce weight reduction. Changes in the neuroendocrine system may be affected by the JIB-operation, because the proximal small intestinal mucosa has a rich supply of endocrine cells and peptidergic nerves. Materials and Methods: In 37 obese patients operated with JIB 1-30 years ago, small intestinal biopsies were taken at the
Merparten studier som har undersökt hur nattjour påverkar prestation, hälsa och säkerhet, har genomförts i USA där det är vanligt med mycket långa arbetsveckor och arbetspass. Aktuell studie avsåg undersöka effekter av nattjour beträffande kognitiv funktion, riskutsatthet och belastning, under förhållanden representativa för svensk sjukvårdsorganisation. I studien deltog 30 läkare i södra Sverige,Most studies examining how on call duty nighttime affects performance, health and safety, were conducted in the United States where long working weeks and shifts are common. The current study examined the effects of on call duty nighttime on physician´s performance and strain under conditions representative for Swedish healthcare organization. The study enrolled 30 physicians from southern Sweden,
Cerebral Palsy, commonly referred to as CP, is a neurological disorder that results in loss or impairment of motor function, which affects body movement, muscle control, muscle coordination and balance. In Sweden, about 200 children are diagnosed with Cerebral Palsy every year and the disorder can cause imbalances between the muscles. These imbalances can lead to contractures which is equiva- lent
Establishing a technically practical method to generate representative model catalysts for the use in characterizations and testing prior to catalyst implementation in chemical process units would allow for a more sophisticated understanding of the underlying catalytic mechanisms. As a step towards establishing such a method, generating non-agglomerated, spherical NiMo nanoparticles, with diameter
Recent research has noticed that the picture of the second-generation immigrants negotiating their identity in media space is different and far more complex than the first generation. With their emergence in the new age of digitalisation, the second-generation immigrant is offered more media choices and freedom of access to the two most important cultural sets of host and homeland country to make
The purpose of this thesis is to develop a blind spot detection system for increased safety and comfort for a biker. The solution is based on power-efficient small A111 radars, developed by Acconeer AB, which have a range up to seven meters while consuming only a few milliwatts. Sensor evaluation is performed for the intended use and from this, concepts are generated. These are tested to obtain t
The start-up company LEVTEK is launching a new ultralight electric utility vehicle called the LEVKART. The Levkart uses a combination of robotics and AI-technology to offer semi-autonomous or autonomous riding and usage. The purpose of the vehicle is to serve as an alternative to cargo bikes and electric scooters designed for easy usage and as a more sustainable option to fossil-based transport. T
Uppsatsen utreder plenumbestämmelsens tillämpningsproblem inom straffrätten och hur förutsebarheten för den enskilde påverkas av att plenumbestämmelsen lyser med sin frånvaro. Prejudikaträtten är inte absolut i Sverige. Men detta innebär inte att ändringar av prejudikat ska ske med lätthet, utan en strävan att upprätthålla förutsebarheten för den enskilde är viktig. Med anledning av detta finnerThe essay examines the absence of the application by the Supreme Court of plenary sessions, which is necessary for establishment of precedent in the Swedish legal system, within the penal law and how the predictability in individual cases thus suffers. The precedence principal is not consistently adhered to by the Swedish legal system. This does not suggest that changes of precedent should be ma
Cardiac arrest effectiveness trials have traditionally reported outcomes that focus on survival. A lack of consistency in outcome reporting between trials limits the opportunities to pool results for meta-analysis. The COSCA initiative (Core Outcome Set for Cardiac Arrest), a partnership between patients, their partners, clinicians, research scientists, and the International Liaison Committee on R
Cardiac arrest effectiveness trials have traditionally reported outcomes that focus on survival. A lack of consistency in outcome reporting between trials limits the opportunities to pool results for meta-analysis. The COSCA initiative (Core Outcome Set for Cardiac Arrest), a partnership between patients, their partners, clinicians, research scientists, and the International Liaison Committee on R
We studied avian development in 49 to 153 species of temperate and tropical New World passerine birds to determine how growth rates, and incubation and nestling periods, varied in relation to other life-history traits. We collected growth data and generated unbiased mass and tarsus growth rate estimates (mass n = 92 species, tarsus n = 49 species), and measured incubation period (n = 151) and nest
Glutamatergic transmission is an important factor in the development of neuronal death following transient cerebral ischemia. In this investigation the effects of N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists on neuronal damage were studied in rats exposed to 10 min of transient cerebral ischemia induced by bilateral common carotid occlusion combined with hypotension. The animals w
We compare abundance ratio trends in a sample of ∼11,000 Milky Way bulge stars (R GC < 3 kpc) from the Apache Point Observatory Galactic Evolution Experiment (APOGEE) to those of APOGEE stars in the Galactic disk (5 kpc < R GC < 11 kpc). We divide each sample into low-Ia (high-[Mg/Fe]) and high-Ia (low-[Mg/Fe]) populations, and in each population, we examine the median trends of [X/Mg] versus [Mg/
Background: Question-based computational language assessments (QCLA) of mental health, based on self-reported and freely generated word responses and analyzed with artificial intelligence, is a potential complement to rating scales for identifying mental health issues. This study aimed to examine to what extent this method captures items related to the primary and secondary symptoms associated wit
Aims: Information on standards including structure- and process-based metrics and how exercise-based cardiac rehabilitation (EBCR) is delivered in relation to guidelines is lacking. The aims of the study were to evaluate standards and adherence to guidelines at Swedish CR centers and to conduct a cost analysis of the physiotherapy-related activities of EBCR. Methods and Results: EBCR standards at
The aim of this study was to identify molecules that trigger complement activation in rheumatic joints. C4d, the final cleavage product of C4 activation, is found in the diseased joint and can bind covalently to complement-activating molecules. By using a highly specific Ab against a cleavage neoepitope in C4d, several molecules that were specifically bound to C4d were identified from pooled synov
In Part I of this two-part paper, a formulation was developed to treat fragmentation in ice-ice collisions. In the present Part II, the formulation is implemented in two microphysically advanced cloud models simulating a convective line observed over the U.S. high plains. One model is 2D with a spectral bin microphysics scheme. The other has a hybrid bin-two-moment bulk microphysics scheme in 3D.
This paper revises the design process for closed-loop combustion control based on in-cycle feedback. Methods for the necessary observers, detectors and virtual sensors are also discussed. The control problem tackles the indicated efficiency optimization, following two approaches, direct and indirect optimization. The argumentation provides a comprehensive overview on how to specify and integrate d
Microbial stoichiometry has become a key aspect in ecological research as shifts in microbial C:N, C:P and N:P ratios upon nutrient addition are presumed to give insight into relative nutrient limitations for soil microorganisms–with far-reaching implications for biogeochemical processes. However, this expectation has never been tested against direct methods of microbial growth responses to nutrie
