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Summertime Rossby waves in climate models : Substantial biases in surface imprint associated with small biases in upper-level circulation

In boreal summer, circumglobal Rossby waves can promote stagnating weather systems that favor extreme events like heat waves or droughts. Recent work showed that amplified Rossby wavenumber 5 and 7 show phase-locking behavior which can trigger simultaneous warm anomalies in different breadbasket regions in the Northern Hemisphere. These types of wave patterns thus pose a potential threat to human

Sociodemographic Disparities and Parity in Relation to Urinary Incontinence : A Nationwide Primary Healthcare Cohort Study (1997–2018)

Objectives: Urinary incontinence (UI) is a very common condition in the primary healthcare settings. Few studies have investigated whether sociodemographic factors are related to UI. This nationwide study aimed to investigate whether there is a relationship between sociodemographic factors and UI in women. Methods: A nationwide open cohort study included 2,044,065 women aged 15–50 years. Several n

Bringing on the Social : Infrastructuring Libraries Through Zine-making Workshops

Public libraries serve as social infrastructures that foster interpersonal connections and promote well-being and cohesion. In order to explore the role played by libraries in the process of social infrastructuring, we conducted a zine-making workshop with librarians. This workshop facilitated collegial conversations and provided an opportunity for participants to familiarize themselves with the c

Sapwood and heartwood affect differentially bacterial and fungal community structure and successional dynamics during Quercus petraea decomposition

In forests, bacteria and fungi are key players in wood degradation. Still, studies focusing on bacterial and fungal successions during the decomposition process depending on the wood types (i.e. sapwood and heartwood) remain scarce. This study aimed to understand the effect of wood type on the dynamics of microbial ecological guilds in wood decomposition. Using Illumina metabarcoding, bacterial an

Cellular polyamines promote amyloid-beta (Aβ) peptide fibrillation and modulate the aggregation pathways

The cellular polyamines spermine, spermidine, and their metabolic precursor putrescine, have long been associated with cell-growth, tumor-related gene regulations, and Alzheimer's disease. Here, we show by in vitro spectroscopy and AFM imaging, that these molecules promote aggregation of amyloid-beta (Aβ) peptides into fibrils and modulate the aggregation pathways. NMR measurements showed that the

Analysis of Control Systems Under Sensor Timing Misalignments

This paper presents an in-depth analysis of the stability and performance of control systems experiencing sensor timing misalignments, a common challenge in practical applications such as autonomous vehicles and aerospace systems. We model multichannel sensor delays as independent random variables, capturing the variability of real-world systems where different sensors exhibit distinct and non-con

Ceramides : a potential cardiovascular biomarker in young adult childhood cancer survivors?

Aims The aim of this study was to investigate circulating ceramides involved in cardiovascular disease (CVD) in young adult childhood cancer survivors (CCS) and their correlations to previously reported adverse cardiovascular changes in this cohort. Methods Fifty-seven CCS and 53 healthy controls (age 20-30 years) were studied. Plasma long-chain ceramides, known to be cardi- and results otoxic (C1

Plotinus

The philosophy of Plotinus plays a contradictory role in Giorgio Agamben’s corpus. He comments on Plotinus in a lapidary fashion in several articles and essays before commencing the Homo Sacer series, where he undertakes a longer and more ambiguous analysis of Plotinus in Opus Dei and The Use of Bodies. In Opus Dei, Agamben develops the brief criticism of Plotinus he proposed in The Kingdom and th

IoT based reliable and efficient vaccines monitoring and distribution system

A successful vaccination program depends on secure vaccine storage as well as safe and effective vaccine delivery. An Internet of Things (IoT) based vaccine distribution and monitoring model, which is used to transport and monitor vaccines to locations where they will be properly kept for eventual use, is developed and tested. Coronavirus (COVID-19) was first identified in December 2019 in Wuhan c

Sensitivity of simulated knee joint mechanics to selected human and bovine fibril-reinforced poroelastic material properties

Fibril-reinforced poroviscoelastic material models are considered state-of-the-art in modeling articular cartilage biomechanics. Yet, cartilage material parameters are often based on bovine tissue properties in computational knee joint models, although bovine properties are distinctly different from those of humans. Thus, we aimed to investigate how cartilage mechanical responses are affected in t

Governance, Good

This article argues that despite the fact that “good governance” has acquired a very particular set of meanings within the international development community, this remains an inherently contested and political concept. It traces the emergence of a good governance agenda within international development—and particularly within the World Bank—and identifies the important shifts that have occurred i

A tale of two coals : the politics of time in coal phase out

Collective social and political imaginaries of energy transitions are underpinned by a particular temporality of linear, teleological paths of progress and modernity, conjuring an abstract future. But what happens when the future is suddenly here? Drawing on sociological and related literatures on ruination and decay, this article offers insights into how different actors respond when they find th

Simulated sensitivity of the Amazon rainforest to extreme drought

The Amazon rainforest is highly biodiverse and has the largest extent of the remaining intact tropical forests in the world. To this day, undisturbed tropical forests act as a carbon sink by taking up about 15% of anthropogenic carbon emissions per year. However, in the past decades, a declining trend in the carbon sink capacity in the Amazon rainforest has been observed due to increased carbon lo

Neuroendocrine Prostate Cancer: FDG-PET and Targeted Molecular Imaging

Purpose/Objective(s): Over 30% of advanced prostate cancers harbor a predominance of neuroendocrine prostate cancer (NEPC) differentiation. Fluorodeoxyglucose (FDG) positron emission tomography (PET) has numerous limitations in prostate adenocarcinoma (PCa-adeno), however there is no data that exists outside of isolated single person case reports to assess the utility of PET to restage and monitor

Generation of human astrocytes for disease modeling. A study based on stem cells, direct conversion and genome engineering to dissect the role of astrocytes in leukodystrophies

Astrocytes are one of the major cell types in the central nervous system and are indispensable for brain development and function. The human brain and human astrocytes have unique structures and functions that are not present in other animal species. Studies of fundamental astrocyte biology in humans and their role in neurological disease have been hindered by shortage of native human astrocytes f

A practical guide for in situ mechanical testing of musculoskeletal tissues using synchrotron tomography

Musculoskeletal tissues are complex hierarchical materials where mechanical response is linked to structural and material properties at different dimensional levels. Therefore, high-resolution three-dimensional tomography is very useful for assessing tissue properties at different scales. In particular, Synchrotron Radiation micro-Computed Tomography (SR-microCT) has been used in several applicati

Crisis in the City: Emergency Urbanism

This paper deals with the question how urban crises – whether political, economic, financial, environmental or social – are defined, constructed, or discursively and materially appropriated by urban elites to serve their agendas of urban reform. Inspired by the work of Klein (2007), Smith (2005) and others, it will be argued that specific ‘emergency’ framings of urban decline, impoverishment, disa

Stochastic modeling and simulation of traffic flow: asymmetric single exclusion process with Arrhenius look-ahead dynamics

A novel traffic flow model based on stochastic microscopic dynamics is introduced and analyzed. Vehicles advance based on the energy profile of their surrounding traffic implementing the "look-ahead" rule and following an underlying asymmetric exclusion process with Arrhenius spin-exchange dynamics. Monte Carlo simulations produce numerical solutions of the microscopic traffic model. Fluctuations