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Association of energy availability with resting metabolic rates in competitive female teenage runners : a cross-sectional study

Background: Resting metabolic rate (RMR) has been examined as a proxy for low energy availability (EA). Previous studies have been limited to adult athletes, despite the serious health consequences of low EA, particularly during adolescence. This study aimed to explore the relationship between RMR and EA in competitive teenage girl runners. Methods: Eighteen girl runners (mean ± standard-deviation

Natural history and surgical outcome of Rathke's cleft cysts—A study from the Swedish Pituitary Registry

Objective: Rathke's cleft cysts are benign, embryological remnants in the pituitary gland. The majority of them are small and asymptomatic but a few may become large, and cause mass effects, pituitary hormone deficiencies and visual impairment. Recommendations for the follow-up of Rathke's cleft cysts vary since data on the natural history are sparse. Patients and Design: Data at diagnosis and at

Untangling the threads of cellulose mercerization

Naturally occurring plant cellulose, our most abundant renewable resource, consists of fibers of long polymer chains that are tightly packed in parallel arrays in either of two crystal phases collectively referred to as cellulose I. During mercerization, a process that involves treatment with sodium hydroxide, cellulose goes through a conversion to another crystal form called cellulose II, within

Generation, characterization and application of infrared few-cycle light pulses

In recent decades, laser systems emitting pulses of light containing only a few electric field oscillations under their envelope have become common in many ultrafast optics laboratories. Owing to unique temporal characteristics and achieving extreme field strengths, these so-­called few­-cycle pulses have been instrumental in unlocking new regimes of light-­matter interaction.The work presented in

How to measure the impact of place marketing activities: a methodological discussion

This paper aims to explicate and discuss the main methods of measuring the effects of place marketing. Rather than favouring one method over another a priori, we seek to understand each method on its own terms in order to illuminate key assumptions and hypotheses. Additionally, we compare and contrast the different methods to reveal areas of logical inconsistency.Generally, the impact of place mar

Quality of life in patients with metastatic breast cancer receiving either docetaxel or sequential methotrexate and 5-fluorouracil. A multicentre randomised phase III trial by the Scandinavian breast group

The purpose of this study was to evaluate the effects of two alternative chemotherapy regimes on the quality of life (QoL) of patients with advanced breast cancer. In a multicentre trial, 283 patients were randomised to receive either docetaxel (T) or sequential methotrexate and 5-fluorouracil (MF). QoL was assessed at baseline and before each treatment using the European Organization for Research

Scaffolding structures to promote widening participation in higher education–a meta-ethnographic analysis of qualitative studies

Introduction: Widening participation in education by including students from underrepresented groups has been recognized as important for the last decade. During the recent pandemic, the interest in how to make students from different backgrounds feel part of the university, and connected to their studies and peers, has become an even more widespread concern and therefore important to explore furt

Controlled Trapping in Laser Wakefield Accelerators

Experimental studies of laser-driven acceleration of charged particles, in particular electrons and protons, are described in this dissertation. Tightly focused femtosecond laser pulses with intensities exceeding 1018 W/cm2 were used to accelerate charged particles to high energies over distances of a few millimeters. Although the transverse fields of such laser pulses are sufficient to directly a

Allergic eosinophil-rich inflammation develops in lungs and airways of B cell-deficient mice

Immunoglobulins (Ig), particularly IgE, are believed to be crucially involved in the pathogenesis of asthma and, equally, in allergic models of the disease. To validate this paradigm we examined homozygous mutant C57BL/6 mice, which are B cell deficient, lacking all Ig. Mice were immunized intraperitoneally with 10 micrograms ovalbumin (OVA) plus alum, followed by daily (day 14-20) 30 min exposure

Detection of Brief Episodes of Atrial Fibrillation Based on Electrocardiomatrix and Convolutional Neural Network

Background: Brief episodes of atrial fibrillation (AF) may evolve into longer AF episodes increasing the chances of thrombus formation, stroke, and death. Classical methods for AF detection investigate rhythm irregularity or P-wave absence in the ECG, while deep learning approaches profit from the availability of annotated ECG databases to learn discriminatory features linked to different diagnosi

Patterns of Lifetime Criminality in Mentally Disordered Offenders – Findings From a Nationally Representative Cohort

Background: Treatment of mentally disordered offenders (MDOs) is challenging as their behavior and clinical conditions can be traced to a complex constellation of major mental disorders, substance use and antisocial lifestyle. Finding subgroups of these offenders, which could guide treatment and risk assessment, is desirable. There are few long-term, prospective studies of risk factors for persist

Copeptin as a predictive marker of incident heart failure

AIMS: Heart failure (HF) is a common disease with increasing prevalence and poor prognosis. The vasopressin (VP) marker copeptin predicts development of diabetes mellitus, diabetic heart disease, coronary artery disease, and premature mortality. Copeptin is elevated in HF patients and predicts a worse outcome. This study aims to investigate whether copeptin can predict HF development.METHODS: Cope

Health-related quality of life, lifestyle habits and chronic pain in individuals with knee pain–a 2-year follow-up study

Introduction: Knee pain increases the risk of developing chronic widespread pain (CWP) and knee osteoarthritis (KOA). The prevalence of CWP and KOA has increased, and there is a need for early prevention. Therefore, the aim was to examine the associations of health-related quality of life (HRQoL) and lifestyle habits with chronic pain at a two-year follow-up in individuals with knee pain. Methods:

The association of travel distance and other patient characteristics with breast cancer stage at diagnosis and treatment completion at a rural Rwandan cancer facility

Background: Butaro Cancer Center of Excellence (BCCOE) was founded to serve Rwanda’s rural low-income population, providing subsidized cancer diagnosis and treatment with transport stipends for the lowest-income patients. We examined whether travel distance to BCCOE was associated with advanced-stage diagnoses and treatment completion. Methods: We conducted a retrospective cohort study using medic

Estimating historical PFAS exposures in Ronneby, Sweden using biobanked dried blood spots from newborns

BACKGROUND: In 2013, it was discovered that a subset of the population in Ronneby, Sweden was exposed to high levels of perfluorinated compounds (PFAS) from drinking water that had been provided by the local Brantafors waterworks and was contaminated by fire-fighting foam from a nearby airport. The start and time-course of population exposures are not known.OBJECTIVE: To investigate the start of P

Global activity distribution in the cortex: A look on how a global network handles information and perturbations

Studies on cortical function have been a cornerstone in research trying to understand our brains for a long time. For many years now a basic feature of cortical processing has been the idea of a functional localization, with different areas or even neurons in the cortex having clear, individual, functions. This idea has been challenged from the outset, and with new methods to study the cortex the

Competitive surface complexation of o-phthalate and phosphate on goethite (alpha-FeOOH) particles

Complexation of o-phthalate (1,2-benzenedicarboxylate) and competitive complexation of phosphate and phthalate at the goethite-water interface have been studied in 0.1 M Na(NO3) media at 298.2 K within the range 3.0 < -log [H+] < 8.5. Equilibrium measurements were performed as potentiometric titrations supplemented with spectrophotometric phosphate and phthalate analyses. The binary and ternary ch

Palaeolithic diet decreases fasting plasma leptin concentrations more than a diabetes diet in patients with type 2 diabetes : A randomised cross-over trial

Background: We have previously shown that a Palaeolithic diet consisting of the typical food groups that our ancestors ate during the Palaeolithic era, improves cardiovascular disease risk factors and glucose control compared to the currently recommended diabetes diet in patients with type 2 diabetes. To elucidate the mechanisms behind these effects, we evaluated fasting plasma concentrations of g