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OBJECTIVE Patients with latent autoimmune diabetes in adults (LADA) express autoantibodies against the 65-kDa isoform of GAD (GADA). Intervention with recombinant human GAD65 formulated with aluminium hydroxide (GAD-alum) given twice subcutaneously to LADA patients at intervals of 4 weeks was safe and did not compromise beta-cell function in a Phase II clinical trial. GADA affinity has been shown

Objective: To evaluate under- and overreporting and their determinants in the EPIC :24-hour diet recall (24-HDR) measurements collected in the European Prospective Investigation into Cancer and Nutrition (EPIC). Design: Cross-sectional analysis. 24-HDR measurements were obtained by means of a standardised computerised interview program (EPIC-SOFT). The ratio of reported energy intake (EI) to estim

The UV photodissociation (<5 eV) of diiodomethane (CH(2)l(2)) is investigated by spin-orbit ab inito calculations. The experimentally observed photodissociation channels in the gas and condensed phases are clearly assigned by multi-state second-order multiconfigurational perturbation theory in conjunction with spin-orbit interaction through complete active space-state interaction potential energy

Background Although childbearing is known to protect against breast cancer, whether or not breastfeeding contributes to this protective effect is unclear. Methods Individual data from 47 epidemiological studies in 30 countries that included information on breastfeeding patterns and other aspects of childbearing were collected, checked, and analysed centrally, for 50 302 women with invasive breas

A classical solution for matching two image patches is to use the cross-correlation coefficient. This works well if there is a lot of structure within the patches, but not so well if the patches are close to uniform. This means that some patches are matched with more confidence than others. By estimating this uncertainty more weight can be put on the confident matches than those that are more unce

This paper seeks to provide an overview of how companies assess and manage security risks in practice. For this purpose we referred to data of security surveys to examine the scope of risk analysis and to identify involved entities in this process. Our analysis shows a continuous focus on data system security rather than on real world organizational context as well as a prevalent involvement of to

ERP systems became popular with large organizations in the 1990s. In the 21st Century, these products were expanded by addition of supply chain management (SCM) and customer relationship management (CRM), as well as access through the Web, creating the ERP II concept. Efforts to increase the market led vendors to serve not only large organizations, but also focus more on small-to-medium sized ente

An essential problem of ‘knowledge management’ is the impossibility of codifying ‘knowledge’ which is embedded in human agents. It can never be straightforward for members of an organization to share what they know with one another. Such a process might be facilitated, but would be difficult to ‘manage’. In recognition of this, organizations have sought ways to support knowledge sharing processes,

Popular Abstract in Swedish Genom att utsätta ett material för elektromagnetisk strålning med tillräckligt hög frekvens kan man "slå ut" elektroner. Denna mekanism, som förklarades av Albert Einstein redan 1905, går under namnet den fotoelektriska effekten och utnyttjas idag bl.a. i fotoemissionsexperiment. I dessa experiment analyserar man energin hos de utsända elektronerna och kan dra slutsatseThe present thesis is concerned with the theoretical study of x-ray photoemission spectra from clean and adsorbate-covered metal surfaces. The main tool is ab initio density functional (DFT) total energy calculations. The first part gives an overview of the theoretical treatment of x-ray photoemission with our present contributions highlighted, and an introduction to DFT theory and computational t

BACKGROUND AND AIMS: Mobility devices (MDs) such as walking sticks, rollators and wheelchairs, often play an important role for older people living at home, striving to remain independent in everyday activities. The aim of this study was to explore how the use of MDs changes over time among very old people in five European countries. METHODS: Empirical data from the ENABLE-AGE Survey Study, part o

The photodissociation of bromoiodomethane has been investigated by spin-orbit ab initio calculations. The experimentally observed A- and B-bands and the corresponding photoproducts were assigned by multistate second-order multiconfigurationol perturbation theory in conjunction with spin-orbit interaction through complete active space state interaction potential energy curves, vertical excitation e

Measurements of the net CO2 flux between terrestrial ecosystems and the atmosphere using the eddy covariance technique have the potential to underpin our interpretation of regional CO2 source-sink patterns, CO2 flux responses to forcings, and predictions of the future terrestrial C balance. Information contained in FLUXNET eddy covariance data has multiple uses for the development and application

A computer-controlled biochemical oxygen demand (BOD) analyzer has been developed for fast estimation of biochemical oxygen demand (BOD,,) automatically with the purpose of on-line monitoring of a process for conversion of biomass under field conditions. The instrument was tested by on-line monitoring of the connecting stream between two stages of a two-stage anaerobic process in laboratory scale.

Despite declining incidence rates, gastric cancer (GC) is a major cause of death worldwide. Its aetiology may involve dietary antioxidant micronutrients such as carotenoids and tocopherols. The objective of this study was to determine the association of plasma levels of seven common carotenoids, their total plasma concentration, retinol and alpha- and gamma-tocopherol, with the risk of gastric ade

The theoretical background and research evidence supporting two alternative scenarios – worsening health and improving health at increasing life expectancy is analyzed. It is shown that the prevailing “longer life – worse health” theory is based on the logic that due to the reduced birth-rate and increased proportion of older citizens the process of population aging is taking place, leading to an

Popular Abstract in Swedish Studien handlar om fysiologen Frithiof Holmgrens försök att fastställa seendets natur på experimentell väg. Avsikten är att problematisera Holmgrens intresse för synsinnet mot bakgrund av de metoder och vetenskapliga ideal som var förhärskande inom den experimentella fysiologin, det ämne som Holmgren introducerade i Sverige 1862. Generellt kan man säga att Holmgrens forThis study deals with research on the visual organ as pursued in experimental physiology during the latter half of the nineteenth-century. In the 1850's och 60's experimental physiology developed as a new, scientific discipline within the curriculum of western medicine. By opposing the natural philosophical and vitalistic viewpoint of romantic medicine and by proclaiming measuring devices, animal

In most genres of fiction representations of a profession, discipline or calling must broadly resonate with the conceptions of that role held by audiences. But very few represenations of PR practice to be found in novels written by UK-based writers draw a picture of PR activity that sits comfortably with the ”idealised” models offered by organisations such as the Chartered Institute of Public Re

Hairdressers are exposed to high levels of chemicals, including possible carcinogens. For dermal exposure, the skin protects against the uptake of chemicals and the protein filaggrin (encoded by FLG) has a key role in skin barrier function. This study investigated if variants of FLG previously linked to impaired skin barrier function, i.e. null mutations and copy number variation (CNV) alleles (CN