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Metastatic Breast Cancer: Biomolecular Characterization and Targeted Therapy

Popular Abstract in English Every year globally, an estimated 1.7 million women are diagnosed with breast cancer, while over half a million are killed by this disease. The principal cause of death is metastasis, which is the spreading of the cancer cells from the breast to other vital organs like the brain, liver or lungs, resulting in organ failure and subsequently death. Even though the past decMetastasis is a complex process that remains a major challenge in the clinical management of cancer, because most cancer-related deaths are attributed to disseminated disease rather than the primary tumor. Despite the significant advances in the prediction of prognosis, and therapeutic management of primary breast cancers, coupled with the substantial improvement in our understanding of the molecu

Can histology solve the riddle of non-functioning electrodes; factors influencing the biocompatibillity of brain machine interfaces.

Neural interfaces hold great promise to become invaluable clinical and diagnostic tools in the near future. However, the biocompatibility and the long-term stability of the implanted interfaces are far from optimized. There are several factors that need to be addressed and standardized when improving the long-term success of an implanted electrode. We have chosen to focus on three key factors when

The African Court of Justice and Human Rights: An Opportunity to Strengthen Human Rights Protection

Taking in to consideration the countless human rights violations and impunity in Africa, there is not a shred of doubt about the dire need for effective human rights protection mechanisms at continental level. This concern has mainly increased due to the Africa Commission’s poor track record of enforcement of human rights norms in the region. Hence, it is in the effort to cure the ills suffered by

Corporate Social Responsibility in Chinese state owned enterprises

The interest in Corporate Social Responsibility (CSR) has grown tremendously within the last decades. Due to the pressure from different stakeholders, this concept was introduced by multinational corporations (MNC) in China. Since the strong focus on economic growth has been determining the way of doing business, environmental and social concerns were not taken into account appropriately. Since MN

Samhällets val - vem kan välja? Möjligheter till deltagande i allmänna val för personer med intellektuell funktionsnedsättning i relation till den svenska nationella målsättningen om ett samhälle tillgängligt för alla.

The choice of society – who is to vote? Opportunities to participation in the general elections for people with intellectual disabilities related to the Swedish national objective of an accessible society for all citizens The aim of this study is twofold; first to examine how Swedish government authorities and other relevant actors in the society regard the accessibility of general elections for

Upper Ordovician graptolites and biostratigraphy of the Rostanga 1 core, Scania, S. Sweden

drilling at Rostanga in 1997, referred to as Rostanga 1, penetrated a significant portion of the Upper Ordovician-Lower Silurian succession in this classical Lower Palaeozoic outcrop area in W-central Scania. In descending order the Upper Ordovician of the core embraces the following units (stratigraphic thickness in parenthesis): Lindegard Mudstone (27.8 m), Fjacka Shale (13.6 m), Mossen Formatio

Reflection/Transmission Study of Two Fabrics with Microwave Properties

In this study, the transmission and reflection of two conductive fabrics are investigated in the frequency range from 2 to 18 GHz. One of the fabrics is a non-woven polypyrrole and the other consists of a polyethylene warp with steel threads in the weft. Reflection and transmission measurements are performed in order to characterize the electromagnetic properties of the materials. Reflection measu

A Pill for the Ill? Patients’ Reports of Their Experience of the Medical Encounter in the Treatment of Depression

Background Starting in the 1960s, a broad-based patients’ rights movement began to question doctors’ paternalism and to demand disclosure of medical information, informed consent, and active participation by the individual in personal health care. According to scholars, these changes contributed to downplay the biomedical approach in favor of a more patient-oriented perspective. The Swedish non-p

Novel risk factors for atrial fibrillation in an urban population

Popular Abstract in Swedish Förmaksflimmer är den vanligaste rytmrubbningen i hjärtat. Man beräknar att 1-2% av befolkningen har förmaksflimmer. Förmaksflimmer blir vanligare med stigande ålder. Bland personer äldre än 75 år har 5-10% förmaksflimmer. Var fjärde person över 40 år riskerar att drabbas av förmaksflimmer någon gång i livet. Förmaksflimmer ger bl.a. en ökad risk för blodproppar och strAtrial fibrillation (AF) is the most common sustained cardiac arrhythmia in the general population, and a major cause of morbidity and mortality. Low-grade inflammation, erythrocyte volume variation, and subclinical atherosclerosis have repeatedly been associated with cardiovascular disease, but it remains unclear whether these risk factors are also associated with incident AF. This thesis is bas

Lessons Learned in Knowledge Managment - the case of construction

The construction sector has been criticised in recent years for being inefficient. The critique involved describes finished buildings as having flaws and there being a lack of interest within the construction sector in assembling knowledge and sharing experience. The construction industry has started working with questions of how efficiency can be increased by reducing the errors made. Knowledge

The formation of Staphylococcus aureus enterotoxin in food environments and advances in risk assessment.

The recent finding that the formation of staphylococcal enterotoxins in food is very different from that in cultures of pure Staphylococcus aureus sheds new light on, and brings into question, traditional microbial risk assessment methods based on planktonic liquid cultures. In fact, most bacteria in food appear to be associated with surfaces or tissues in various ways, and interaction with other

Advanced multiresponsive comploids: from design to possible applications.

We extend the commonly used synthesis strategies for responsive microgels to the design of novel multiresponsive and multifunctional nanoparticles that combine inorganic magnetic, metallic/catalytic and thermoresponsive organic moieties. Magnetic responsiveness is implemented through the integration of silica-coated maghemite nanoparticles into fluorescently labeled crosslinked poly(N-isopropylmet

Effect of genetic variation on the tryptic hydrolysis of bovine beta-lactoglobulin A, B, and C

The structure, stability, and hydrolysis characteristics of beta-lactoglobulin (LG) A are different from those of either beta-LG B or beta-LG C. Purified samples of these proteins were hydrolyzed with trypsin and the rates of loss of native monomeric beta-LG structure were measured using sodium dodecyl sulfate PAGE. At the same time, the appearance of many individual peptides were identified and f

Photography and temperature measurements from a remotely piloted vehicle

Radio-controlled model planes are useful when carrying out photography, especially from low altitudes, and meteorological soundings (air temperatures in boundary layers). Soundings were carried out with a system which stored the measured data on board the plane pending evaluation after the flight. The payload of the plane was a camera and equipment for measuring temperature and air pressure (altit

Reflections on 10 years of software process simulation modeling: a systematic review

Software process simulation modeling (SPSM) has become an increasingly active research area since its introduction in the late 1980s. Particularly during the last ten years the related research community and the number of publications have been growing. The objective of this research is to provide insights about the evolution of SPSM research during the last 10 years. A systematic literature revie

Aerosol phase generation of In-Se nanoparticles

Results on the generation and heat treatment of In-Se nanoparticles, made by heterogeneous condensation of selenium on indium nanoparticles synthesised via the evaporation/condensation route are reported. In-situ aerosol measurements are complemented with ex-situ analysis, to provide structural, morphological, and compositional information on the In-Se nanoparticles. Our results indicate that prio