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Background: There is little agreement on clinically useful criteria for identifying real-world responders to biologic treatments for asthma. Objective: To investigate the impact of pre-biologic impairment on meeting domain-specific biologic responder definitions in adults with severe asthma. Methods: This was a longitudinal, cohort study across 22 countries participating in the International Sever

Recent studies have explored the influence of obesity and critical illness on ciprofloxacin pharmacokinetics. However, variation across the subpopulation of individuals with obesity admitted to the intensive care unit (ICU) with varying renal function remains unexamined. This study aims to characterize ciprofloxacin pharmacokinetics in ICU patients with obesity and provide dose recommendations for

Background: Ice hockey players often undergo arthroscopic treatment for femoroacetabular impingement syndrome (FAIS); however, only a few studies have reported postoperative patient-reported outcomes. It has been debated whether player position is related to FAIS. Purpose: To evaluate the change in patient-reported outcome measures (PROMs) in high-level ice hockey players from presurgery to 2 year

In recent years, lithium production has been increasing as a result of the growing market demand. Salt-lake brines are one of the main sources of raw lithium, which can be concentrated and purified by natural evaporation. This time-consuming production causes a loss of around 85–95 % of the water contained in the extracted brine. In this context, new technologies could replace the current process

It can be difficult to engage colleagues with the findings and recommendations of an externally-funded project, even when, or perhaps particularly when, it has major implications for institutional processes. The authors were involved with a large single-institution Higher Education change project that aimed to make the university more responsive to changes in curriculum needs, the student voice, e

The study aims to establish the effectiveness of the Danish destination certification scheme – Destination 21. In order to accomplish this, an analytical framework, based upon current tourism and development theory, was constructed against which the scheme was tested. The analytical framework consists from three analyses examining the schemes framework, substance and applicability. It was found th

BACKGROUND: The increasing number of survivors after childhood cancer requires characterization of the late complications of these diseases and their treatment. We examined a large number of possible socio-economic late effects following treatment for acute lymphoblastic leukemia (ALL) in order to identify factors leading to a poor outcome. PROCEDURE: All individuals who had been diagnosed with AL

Forests are crucial for biodiversity, climate stability, and human well-being, yet rising pressures from climate change and conventional forestry practices threaten their resilience and sustainability. Approximately 30% of global forests are managed intensively, often as monoculture plantations, compromising biodiversity conservation, carbon sequestration, and ecosystem stability. Here, we propose

Background: In recent years, fighting arts (e.g., Karate, Judo, Jujitsu, Boxe) have gained broader attention due to their multiple benefits, involving both physical and psychological enhancements for practitioners. Despite that, studies revolving around specific psychological characteristics such as personality traits are scarce. This study explored potential connections between the personality tr

Background and Aims: Substance use disorder (SUD) is related to widespread adverse consequences, including higher suicidality. Shared genetic liability has been demonstrated between SUD and suicidality. Here, we measured the factors that contribute to increased risk of non-fatal suicide attempt among individuals with SUD by focusing upon aggregate genetic risks and both childhood and past-year env

OBJECTIVE: To monitor serum concentrations of the aggrecan alanine-arginine-glycine-serine (ARGS) neoepitope in a clinical trial of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-5 inhibition as disease-modifying therapy of knee osteoarthritis, and to investigate relationships between reduction in ARGS and change in cartilage thickness, knee-related pain and function. DESITo monitor serum concentrations of the aggrecan alanine-arginine-glycine-serine (ARGS) neoepitope in a clinical trial of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-5 inhibition as disease-modifying therapy of knee osteoarthritis, and to investigate relationships between reduction in ARGS and change in cartilage thickness, knee-related pain and function.DesignROCCELLA t

A 3D model at microscale by the lattice Boltzmann method (LBM) is proposed for part of an anode of a solid oxide fuel cell (SOFC) to analyze the interaction between the transport and reaction processes and structural parameters. The equations of charge, momentum, heat and mass transport are simulated in the model. The modeling geometry is created with randomly placed spheres to resemble the part o

This dissertation investigates the use of religious terms and symbols in politics. More specifically, it investigates Muslim politics. Its aim is to analyze the role of religious terms and symbols within a non-fundamentalist political party, namely the Sri Lanka Muslim Congress (SLMC), a Muslim political party that has been part of the democratic process in Sri Lanka since the 1980s. I thereby hop

This study attempts to determine how English Language teaching and learning methods in a Vietnamese classroom might affect learning output. A classroom observation using COLT (Communicative Orientation of Language Teaching–part A) and recordings of four Vietnamese children at grade 5 made immediately after the lesson concluded have been analysed. The analysis of the children' transcript is made ba

Lignocellulose hydrolysate is an abundant substrate for bioethanol production. The ideal microorganism for such a fermentation process should combine rapid and efficient conversion of the available carbon sources to ethanol with high tolerance to ethanol and to inhibitory components in the hydrolysate. A particular biological problem are the pentoses, which are not naturally metabolized by the mai

Inflammatory responses play a vital role at different stages of colorectal carcinogenesis. C-type lectins mediate inflammatory/immune responses and participate in immune escape of pathogens and tumors. Our study aimed to evaluate the correlation between polymorphisms in three C-type lectin genes, CD209, MBL2 and REG4, and colorectal cancer (CRC) risk and clinical outcome. We genotyped 15 potential

Direct bandgap metal lead halide perovskites offer promising optoelectronic properties desirable in a wide range of applications including photodetection. However, the incomplete and poor understanding of the photophysical processes taking place in these materials, along with their poor stability, is the bottleneck for optimisation and further development of metal halide perovskite devices. In thi