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IL1RAP Blockade with a Monoclonal Antibody Reduces Cardiac Inflammation and Preserves Heart Function in Viral and Autoimmune Myocarditis

BACKGROUND: Currently, there are no therapies targeting specific pathogenic pathways in myocarditis. IL (interleukin)-1 blockade has shown promise in preclinical studies and case reports. We hypothesized that blockade of IL1RAP (IL-1 receptor accessory protein), a shared subunit of the IL-1, IL-33, and IL-36 receptors, could be more efficient than IL-1 blockade alone. METHODS: We induced coxsackie

The Lessons of the Gezi Park Protests in Turkey

The mass mobilization and the collective political engagement of the Gezi Park protests of 2013 came as a surprise for many in Turkey. What was new about these large-scale demonstrations was not only the sheer number of people taking place in them (more than 3.5 million), but rather the expansive range of the protesters.This presentation looks into the Gezi events through a research question of Ho

Studies of bacterial surface proteins interacting with the immune system

Popular Abstract in Swedish En av de viktigaste substanserna i vår kropp är proteiner, också kallade äggviteämnen. Proteiner har en mängd olika uppgifter i kroppen, de finns i våra celler där de har olika uppgifter såsom att fungera som enzymer, transportörer, signalsubstanser, eller som skyddsfaktorer. Proteiner ingår också som viktiga beståndsdelar i vävnaderna mellan cellerna och finns dessutomPathogenic bacteria express a wide array of surface proteins that interact with the environment. Many of these proteins are believed to be important for the virulence. This thesis deals with the binding of immunoglobulins (Ig) and complement regulating proteins to certain bacterial surface proteins. Protein L from Peptostreptococcus magnus binds to Igk-light chains while protein A from Staphylococ

Circulating Human Basophils and Dendritic Cell Subsets. Aspects of antigen recognition and presentation in type I allergic immune responses

Popular Abstract in Swedish En tredjedel av befolkningen i världens industrialiserade länder lider av allergi, t.ex. allergisk rinit (hösnuva). Trots detta vet man relativt lite om de cellulära och molekylära mekanismer som ligger till grund för det immunologiska svaret vid allergi. Genom att studera dessa mekanismer kan man hitta sätt att angripa dem, vilket förhoppningsvis kan leda till bättre lAllergic diseases currently affect a third of the population in the industrialized parts of the world. Despite this, the cellular and molecular mechanisms involved in the induction and activation of allergic diseases are not fully clarified. Dendritic cells (DCs) link the innate and adaptive immunity and play vital roles in protective immunity against pathogens, as well as in inducing tolerance t

Local CTLA4 blockade effectively restrains experimental pancreatic adenocarcinoma growth in vivo.

Antibody-mediated blockade of CTLA4 has been shown to be effective in treating a select group of patients with late-stage melanoma. The precise mechanism underlying the clinical activity of CTLA4 immunotherapy is poorly understood, although recent experimental findings indicate that antibody-mediated depletion of regulatory T cells (Tregs) in the tumor microenvironment plays a key role in efficaci

Development in children born very preterm after intrauterine growth restriction with abnormal fetal blood flow

Delivery of fetuses with intrauterine growth restriction (IUGR) with abnormal umbilical artery blood flow in the second trimester represents a clinical dilemma. So far, no evidence based management protocols are available adressing when to deliver these fetuses. The high risk of hypoxia and fetal death has to be balanced against that of extreme preterm birth with associated morbidity. The clinical

No title

This PhD thesis deals with anthropomorphic images from the Vendel and Viking Ages, their contexts and functions. The images are seen as means of communication with “effective power” or agency ("Wirkmächtigkeit"). They could have had a relationship of interaction or partial identity with what was represented, due to the fact that the Vendel and Viking Age societies were largely based on oral tradit

Kraftig

The goal of this project was to design a tool that facilitates the work with and handling of horses in Scandinavia. After reading some literature and making visits to three different horse related businesses the choice were made to look at natural horsemanship. The goal of natural horsemanship is based on mutual respect, trust, communication and understanding. The idea is that you want to give th

Choong shu chun

Microsoft Word - Shu Chun thesis.doc LUMES 2000-2001 Sanitary Landfills: Toward Sustainable Development i ______________________________________________________________________________ Acknowledgement I would like to express my sincere gratitude to Professor Bramryd for his supervision and guidance. Also I would to thank LUMES teachers and colleagues in helping me to broaden my view and knowledge.

https://www.lumes.lu.se/sites/lumes.lu.se/files/choong_shu_chun.pdf - 2026-06-20

AI Education

AI education asd asd asd asd asd a • 1 LUND UNIVERSITY AI-education @ Lund University Report #3 MAGNUS EKBLAD | MIKAEL SUNDSTRÖM 20211210 8. AI Education suggestions 8.1 Strategic framing of courses Courses can be, and are, of course developed based on many factors including teacher capacity or interest, timely topics, links to current research, and much else besides. However, if we imagine this a

https://www.ai.lu.se/sites/ai.lu.se/files/2022-01/AI%20education.pdf - 2026-06-20

Utmätt, utsökt, utmärkt? – Utmätning, exekutiv försäljning och avhysning från bostadsfastigheter i förhållande till EKMR och målet Rousk mot Sverige

År 2003 såldes Jim Rousks hem på exekutiv auktion för en skuld om 6 721 kr. Tio år senare fälldes Sverige i Europadomstolen för att ha kränkt Jim Rousks rätt till hem och egendom vid utmätningen, försäljningen och den efterföljande avhysningen. Europadomstolen kritiserade särskilt att Sverige inte beaktat Rousks intressen tillräckligt i proportionalitetsbedömningar och att utsökningsprocessen saknIn 2003, Jim Rousk’s home was sold at executive auction to enforce a debt of 6 721 SEK. Ten years later, Sweden was held responsible in the European Court of Human Rights (ECtHR) for violating Jim Rousk’s right to his property and home during the attachment, sale, and ensuing eviction. The ECtHR criticized Sweden for not sufficiently considering Rousk’s interests and for not providing satisfactory

"I quickly learnt not to call it an iPad..." - Using touch screen technology whilst working with people with dementia

The purpose of this study was to highlight professionals’ views and aims of using touch screen technology, such as tablets, whilst working with people with dementia. The usage of touch screen technology whilst supporting people with dementia was found to be getting more and more common in today’s society. The study has underlined how the professionals described the tablet, what aims there were by

The Role of CSR in Sustainable Swedish Startups - Beyond Sustainability as an Exclusive Selling Poin

Research Problem: Existent literature has predominantly focused on applying the concept of CSR on large corporations, disregarding the role of CSR in startups despite the fact that CSR related aspects especially in relation to sustainability provide a fruitful avenue for new ventures to base their competitive advantage on. Investigation of the link between CSR and startups is needed since emerging

Separating Movement and Gravity Components in an Acceleration Signal and Implications for the Assessment of Human Daily Physical Activity

Introduction: Human body acceleration is often used as an indicator of daily physical activity in epidemiological research. Raw acceleration signals contain three basic components: movement, gravity, and noise. Separation of these becomes increasingly difficult during rotational movements. We aimed to evaluate five different methods (metrics) of processing acceleration signals on their ability to

Independent Monitor Unit Calculations in Intensity Modulated Radiotherapy

Varje år får cirka 50 000 svenskar diagnosen cancer. Mot detta är strålbehandling en vanlig behandlingsmetod och det uppskattas att cirka en tredjedel av alla som får cancer någon gång under sin behandling får strålbehandling. En viktig sak inom strålbehandling är att patienten får den dos som läkaren har ordinerat. Detta är en så vital detalj inom strålbehandling att SSI, Statens StrålskyddsinsIndependent dose calculations in radiotherapy are important as they help assure that the dose given to the patient is the same as the prescribed. The current version of software Radiation Verification Programme, RVP, does not take into account the effects that occur when a beam from a linear accelerator is moved off-axis. The aim with this project was to find a model for these effects, fit the par

Att åtala eller påtala - om tillsynsmyndighetens skyldighet att anmäla miljöbrott

Sammanfattning Miljöbalkens huvudsyfte är att så långt som möjligt förebygga skador på människor och miljö. Ett av de viktigaste verktygen för att nå detta mål är straffsanktioneringen av överträdelser. I denna uppsats behandlas tillsynsmyndigheternas skyldighet att anmäla miljöbrott. Det huvudsakliga syftet är att utreda omfattningen av tillsynsmyndigheternas anmälningsplikt för misstänkta miljöb

Skill School workshop-serie: Qualitative Analysis and Coding using NVivo

21 september 2026 13:00 till 29 september 2026 16:00 | Samhällsvetenskapligt metodcentrum erbjuder sex metodworkshops i september och oktober 2026. Lärare, forskare och doktorander från samtliga ämnen och fakulteter som önskar bredda och fördjupa sin metodkunskap är välkomna att anmäla sitt intresse. Nedan följer en kort sammanfattning och en länk till Skill Schools webbsida där du hittar mer info

https://www.sam.lu.se/internt/evenemang/skill-school-workshop-serie-qualitative-analysis-and-coding-using-nvivo-0 - 2026-06-19

Skill School workshop-serie: Qualitative Analysis and Coding using NVivo

21 september 2026 13:00 till 29 september 2026 16:00 | Workshop Samhällsvetenskapligt metodcentrum erbjuder sex metodworkshops i september och oktober 2026. Lärare, forskare och doktorander från samtliga ämnen och fakulteter som önskar bredda och fördjupa sin metodkunskap är välkomna att anmäla sitt intresse. Nedan följer en kort sammanfattning och en länk till Skill Schools webbsida där du hittar

https://www.soc.lu.se/evenemang/skill-school-workshop-serie-qualitative-analysis-and-coding-using-nvivo - 2026-06-19