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We characterized the functional properties of a novel set of human anti-CD40 monoclonal antibodies originating from a human phage display library and identified an antibody that strongly activates cells via the CD40 receptor for potential use in HIV therapy. The anti-CD40 antibodies were converted from a single chain antibody fragment format (scFv) to an IgG format and produced in HEK293 cells, an

Progenitor and stem cell transplantation represent therapeutic strategies for retinal disorders that are accompanied by photoreceptor degeneration. The transplanted cells may either replace degenerating photoreceptors or secrete beneficial factors that halt the processes of photoreceptor degeneration. The present study analyzes whether rat retinal progenitor cells differentiated into photoreceptor

Embedded microcontrollers are often programmed in plain C and lacksupport for multithreading and real-time scheduling. This can makeit very cumbersome to implement multirate feedback controlapplications. We have developed the TinyRealTime kernel forthe Atmel ATmega8L AVR to show that it is feasible to usehigh-precision, deadline-based scheduling even in a tiny 8-bitprocessor with 1 KB of RAM. The

The development of a mathematical model and a computer program to facilitate the study of the multi-cylinder paper drying process is presented. Experimentally determined values far different heat and mass transfer coefficients are used to ensure the physical validity of the model. A unique feature of the model is its inclusion of a mass transfer coefficient for the dryer fabric. Thus far, the mass

A new breath alcohol (ethanol) analyzer has been developed, which allows free exhalation, standardizes measured exhaled alcohol concentration to fully saturated water vapor at a body temperature of 37 degrees C (43.95 mg/L) and includes a built-in self-calibration system. We evaluated the performance of this instrument by comparing standardized alcohol concentration in freely expired breath (BrAC)

Mirrorless optical parametric oscillators (MOPOs) are very attractive parametric devices that rely on the nonlinear interaction of counter-propagating photons to inherently establish distributed feedback, without the use of external mirrors or surface coatings. These devices offer unique spectral and coherence properties that will benefit a large variety of applications ranging from spectroscopy t

Background: Orthodontic treatment need has commonly been assessed using treatment need indices during clinical examinations or using photographs in combination with plaster casts. Recently, the use of intraoral photographs alone to screen malocclusions has increased. Objective: This study aimed to validate intraoral photographs for the assessment of orthodontic treatment need. Materials and Method

Den svenska straffprocessen bygger i dag på en i huvudsak ackusatorisk ordning, där åklagaren ansvarar för utredningen medan domstolen har det yttersta ansvaret för att pröva skuldfrågan och bestämma påföljd. Genom införandet av strafflindring enligt 29 kap. 5 a § BrB har incitament skapats för misstänkta att lämna uppgifter om både egen och annans brottslighet. Uppsatsen analyserar hur sådana uppThe Swedish criminal procedure is currently primarily accusatorial, in which the prosecutor is responsible for the investigation, while the court has the ultimate responsibility for determining guilt and imposing a sentence. The introduction of mitigation of a sentence under Chapter 29, Section 5a of the Swedish Penal Code has created incentives for the prosecuted person to provide information abo

We realize strongly confined quantum dots (QDs) in InAs nanowires (NWs) by combining epitaxial crystal-phase control with chemical wet etching. A strong axial confinement is first introduced by growing closely spaced wurtzite (WZ) tunnel barriers in NWs to enclose a zinc blende (ZB) QD. The NW cross-section is then reduced by isotropic etching to obtain very small QDs, with a maximum observed char

The word “desertification” was introduced in 1949 by the French scientist Aubreville in his report “Climats, forêts et désertification de l´Afrique tropicale”. The concept, however, was discussed earlier by European and American scientists in terms of increased sand movements, desiccation, desert and Sahara encroachment and man made deserts. Desertification, at the beginning of last century, mea

The spread of invasive pests is increasing due to greater global transportation and climate change-mediated range shifts. In a new community, these invasive species provide a novel resource that native predators or parasitoids can evolve to utilise. For invasive agricultural pests, this could provide top-down control; however, initial attack rates on invasive species in the wild are generally low.

Purification of biopharmaceuticals has shifted toward continuous and integrated processes, in turn bringing along a need for monitoring and control to maintain a desired separation between the target pharmaceutical and any impurities it may carry. In this study, a cycle-to-cycle control of the retention volumes of two compounds in a chromatographic, ion exchange purification step was developed, al

Lapptestning med palladium och aluminium (Swedish popular science summary)Lapptestning är standardmetoden för påvisning av kontaktallergi. Metoden har använts i över 100 år och utvecklas fortfarande. På 80-talet började flera kliniker i USA och Europa, inklusive Yrkes-och miljödermatologisk avdelning i Malmö, att lapptesta med palladiumklorid for att kunna påvisa palladiumallergi. Palladium är en AbstractThe aim of this thesis was to investigate the prevalence and significance of contact allergy to palladium from a Swedish perspective. Our initial findings made it necessary to also explore the importance of the metal aluminium used in test chamber systems and the effect of aluminium chloride (Al-Cl) in patch test preparations. A retrospective study (study I), with 18,306 patch test results

TRAIN2WIND is a PhD TRAINing school analysing enTRAINment in offshore WIND farms with computer models and experiments. By its very nature, a wind turbine extracts energy from the wind, which is replenished from the wind field on the sides and above due to the ambient turbulence. However, offshore the turbulence is lower, and wind farms are typically larger than onshore, therefore the wind can only

To complete a new Swedish railway line in a much shorter timeframe than today, alter natives to the traditional methods need to be explored. One option is the use of prefabricated concrete slabs elevated on piers, analogous to the concept used in China for building new railways in record time (He et al., 2017). The method has the advantage of directly tackling the barrier effects exhibited by trad

Abstract in FrenchSelon l’hypothèse du “Penser-pour-parler” (Thinking-for-speaking ou TFS), les locuteurs delangues différentes n’organiseraient pas leur pensée de la même manière lors de la préparationmentale de leurs productions. L’objectif de cet article est de proposer une discussion critiquedes travaux effectués dans le paradigme du TFS, à partir des principes de base établis par cecadre théoAccording to the thinking-for-speaking (TFS) hypothesis, speakers of different languages think differently while in the process of mentally preparing content for speech. The aim of the present paper is to critically discuss the research carried out within the TFS paradigm, against the background of the basic tenets laid out by the proponents of this framework. We will show that despite substantial

One of the defining features of animals is their ability to navigate their environment. Using behavioral experiments this topic has been under intense investigation for nearly a century. In insects, this work has largely focused on the remarkable homing abilities of ants and bees. More recently, the neural basis of navigation shifted into the focus of attention. Starting with revealing the neurons