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Background: Real-world data on starting intravenous (IV) vedolizumab (VDZ) and transitioning to subcutaneous (SC) treatment in inflammatory bowel disease (IBD) are scarce. Aims: To assess treatment outcomes of patients with IBD starting IV VDZ and switching to SC VDZ in routine clinical care. Methods: Adult patients with IBD switching from IV to SC VDZ treatment between 1 March 2020 and 31 Decembe

Recent studies have explored the influence of obesity and critical illness on ciprofloxacin pharmacokinetics. However, variation across the subpopulation of individuals with obesity admitted to the intensive care unit (ICU) with varying renal function remains unexamined. This study aims to characterize ciprofloxacin pharmacokinetics in ICU patients with obesity and provide dose recommendations for

Background: Sweden recently adopted new labor induction guidelines lowering the threshold for post-term pregnancies to 41+ weeks. Despite evidence-based foundation, these guidelines stirred controversy among maternity care professionals, who voiced concerns about potential risks and unintended consequences, such as a rising Caesarean section rate. Midwives also highlighted potential impacts on the

Background: Breathlessness is common in the population and can be related to a range of medical conditions. We aimed to evaluate the burden of breathlessness related to different medical conditions in a middle-aged population. Methods: Cross-sectional analysis of the population-based Swedish CArdioPulmonary bioImage Study of adults aged 50–64 years. Breathlessness (modified Medical Research Counci

Purpose: To examine heat exposure at work and home and the work–recovery cycle and temporal variation of kidney strain, muscle injury and inflammation biomarkers in sugarcane workers. Methods: 20 male sugarcane workers (age: 33 ± 7 years) with a workplace Rest.Shade.Hydration (RSH) intervention were observed over 4 days, at the end (18 h post-shift recovery) and beginning of a work week (42 h post

Mirrorless optical parametric oscillators (MOPOs) are very attractive parametric devices that rely on the nonlinear interaction of counter-propagating photons to inherently establish distributed feedback, without the use of external mirrors or surface coatings. These devices offer unique spectral and coherence properties that will benefit a large variety of applications ranging from spectroscopy t

Background Task-sharing of spinal anaesthesia care by non-specialist graduate physicians, termed medical officers (MOs), is commonly practised in rural Indian healthcare facilities to mitigate workforce constraints. We sought to assess whether spinal anaesthesia failure rates of MOs were non-inferior to those of consultant anaesthesiologists (CA) following a standardised educational curriculum. Me

One risk of continuous renal replacement therapy (CRRT) is inadvertent hypothermia (IH), which is defined as a non-therapeutic core temperature decrease below normal. In continuous renal replacement therapy, heat loss will always occur from blood pumped through the dialysis circuit to cooler environment, predisposing for hypothermia. Blood flow and effluent flows are the most important parameters

During the last decades, Germany has been experiencing an ongoing religious and cultural diversification. But despite this process, other groups are still excluded from dominant discourses of the German society. Especially the Muslim population is often presented as being different and oppositional in comparison to the German majority. Since Islam is of rising interest in the integration debate as

Agriculture is an essential economic activity which sustains the livelihood of millions of people around the world. Maize is one of the most grown, consumed and traded cereals in the world mostly because of its adaptability to varied environmental conditions. Maize farming depends on climatic factors like temperature, rainfall and radiation to thrive but this also means that it is very susceptible

During the last decade, upconverting nanoparticles (UCNPs) doped with rare-earth (RE) ions have been extensively studied in the field of biophotonics. Due to their unique properties of anti- Stokes shifted luminescence and with excitation and emission wavelengths optimal for biomedical imaging, they have become an interesting class of fluorescent contrast agents. An issue with downconverting fluor

In mining for extraction of metals residues are often produced. A frequently produced residue is tailings, which potentially contains high amount of metals, soluble salts and acids. Therefore, it is often necessary to deposit, the tailings in stable impoundments, namely tailings dams, if not all tailings produced is used as backfill in mines. In the construction of the tailings dam in Garpenberg,

Amplicon Pipeline - Snabb och automatisk analys av mikroorganismer Vi är omgivna av mikroorganismer. Bakterier, svampar, parasiter, de omger oss och utgör en stor majoritet av allt levande i världen omkring oss. Vi har betydligt fler bakterier i oss än mänskliga celler, och de har stor betydelse för vårt välmående. Men vi behöver rätt verktyg för att kunna studera dem. Mikroorganismer är en bråkRecent advances in the sequencing technology have led to an increasing pressure on the computer programs used for analysing the sequence data. The programs should be able to provide accurate analysis in a reasonable time span. 16S and 18S rRNA analysis is performed by using PCR to amplify the genes from microorganisms present in a sample followed by sequencing of the amplicons. The result is files

Artificiell intelligens (AI) används idag inom en rad olika områden som sjukvård, ekonomi, marknadsföring, bildanalys och taligenkänning. Syftet med den här undersökningen är att se vilken plats AI har, och kommer att få, inom arkitektur och stadsplanering. Genom en litteraturstudie samt intervjuer av representanter från några svenska arkitektkontor undersöker jag vilken effekt AI kan få på hur viArtificial intelligence (AI) is used within a variety of industries such as healthcare, finance, marketing and for image analysis and speech recognition. The purpose of this survey is to examine what role AI has, and will have, within the fields of architecture and urban planning. Through a literature review and interviews of representatives from Swedish architectural offices, I investigate what e

Natural light brings a sense of presence to the physical environment. The interaction between natural light and form puts us in connection with place in a way that can not be simulated or replaced with artificial light. This relationship has fascinated and engaged architects of all times, you could claim that the question of light and form lies at the core of architecture. It is hard to work with

I denna studie vissas att ur ett energiperspektiv är plast och papper ett bättre material än glas att göra dryckesförpackningar av. Det som undersöktes var produktion, transport och återvinning. Pappret var det bättre alternativet i produktion och transport medans plasten var det bättre alternativet när det kom till återvinning. Glas var ett tydligt sämre alternativ ur ett energiperspektiv. ProdukDifferent material is used today for packaging; all of them have different environmental problems. Depending on your perspective one material might be more beneficial than the other. In this study an energy perspective is used when looking at production of the material, the manufacturing of the package and transport of the package in its lifecycle and recovery processes. The materials studied were

This thesis compares the performance of the first-differenced maximum likelihood estimator (FDML) and the Blundell-Bond continuously-updating system GMM estimator of the autoregressive parameter in an AR(1) dynamic panel model without exogenous covariates, particularly focusing on the close-to-non-stationary case. This case is far from trivial, as a high degree of persistence is the norm rather th

I takt med den växande digitaliseringen förändras förutsättningarna för arbetslivet och medarbetare ställer nya krav på sina arbetsgivare. Arbetet med Performance Management behöver förnyas för att möta framtidens behov. För att öka förståelsen för vad som får medarbetare att bli engagerade i sitt arbete, granskades IKEA och deras mål- och utvecklingsprocess. En elektronisk enkät skickades ut tillIn pace with the growing digitalization, the conditions for worklife and coworkers are in continuous change, which in turn changes the demands on the employees. The work with Performance Management needs to be updated to meet the requirements of the future. The purpose with this study is to achieve better understanding what makes coworkers engaged in their work in order to increase their performan

Sverige har en av världens mest generösa föräldraförsäkringar. Föräldraförsäkringen är könsneutralt utformad, men trots detta tar kvinnor ut drygt 75 procent av föräldraledigheten. Syftet med denna uppsats är att, ur ett genusrättsvetenskapligt perspektiv, utreda om en individualiserad föräldraförsäkring borde införas och att genomföra en genuskritisk rättspolitisk studie av rätten genom att appliSweden has one of the world's most generous parental insurance. The parental insurance is designed to be gender neutral, but despite this, women take out more than 75 percent of the parental leave. The purpose of this paper is to, from a gender rights scientific perspective, investigate whether an individualised parental leave should be introduced and to conduct a gender-critical legal policy