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Intense competition in rapidly changing markets puts intense pressure on product definition and the associated requirements engineering processes. An extensive literature review has identified that brand inertia, customer inertia, inappropriate market entry strategies and an inability to satisfy customer needs or expectations are the principle contributors to customer product rejection. While RE p
Mucosal pathogens trigger a local innate host response by activating epithelial cells. Bacterial adherence and Toll-like receptor 4 (TLR4) signaling have been implicated as key events in this process. This study addressed the molecular basis of the epithelial response to gram-negative infection in the human urinary tract. Mucosal biopsies were obtained from kidneys, ureters, and bladders of patien
Pseudomonas aeruginosa is the dominant pathogen causing chronic lung infections in patients with cystic fibrosis (CF). After an initial phase characterized by intermittent colonizations, a chronic infection is established upon conversion of P. aeruginosa from the non-mucoid to the mucoid, alginate-overproducing phenotype. During the chronic infection the isolation of both mucoid and non-mucoid iso
Next-generation sequencing experiments have shown that microRNAs (miRNAs) are expressed in many different isoforms (isomiRs), whose biological relevance is often unclear. We found that mature miR-21, the most widely researched miRNA because of its importance in human disease, is produced in two prevalent isomiR forms that differ by 1 nt at their 3' end, and moreover that the 3' end of miR-21 is po
One of the most important factors governing durability of concrete structures is reinforcement corrosion, and to prevent degradation associated with it, it is desirable to use large concrete covers. However, if the concrete cover is increased, the majority of design methods will predict that the crack widths at the concrete surface increase significantly. This can be contradictory, since the same
In recent times, archaeological documentation strategies have been considerably improved by the use of advanced 3D acquisition systems. Laser scanning, photogrammetry and computer vision techniques provide archaeologists with new opportunities to investigate and document the archaeological record. In spite of this, the amount of data collected and the geometrical complexity of the models resulting
In this paper a fully coupled thermomechanical two-dimensional simulation model for orthogonal cutting is presented. The model is based on the arbitrary Lagrangian-Eulerian formulation with the remeshing technique. The material model used for the workpiece material includes Johnson-Cook plasticity, and as the chip separation criterion the Johnson-Cook damage law is employed. The different friction
In this study, we demonstrate that an integrated approach, combining palaeolimnological records and limnological monitoring data, can increase our understanding of changing ecological patterns and processes in shallow lakes. We focused on recent regime shifts in shallow Lake Krankesjon, southern Sweden, including the collapse of the clear-water state in 1975 and its subsequent recovery in the late
Shannon's seminal approach to estimating information capacity is widely used to quantify information processing by biological systems. However, the Shannon information theory, which is based on power spectrum estimation, necessarily contains two sources of error: time delay bias error and random error. These errors are particularly important for systems with relatively large time delay values and
Charge transport and recombination in nanostructured semiconductors are poorly understood key processes in dye-sensitized solar cells. We have employed time-resolved spectroscopies in the terahertz and visible spectral regions supplemented with Monte Carlo simulations to obtain unique information on these processes. Our results show that charge transport in the active solar cell material can be ve
The article analyzes the recent genre of Islamic children’s picture books, originally produced as a means of religious socialization for the British Muslim communities, but marked on a global Islamic market. Particular attention is devoted to the visual norms of the books produced by one of the pioneering publishers of Islamic children’s literature, the Islamic Foundation. With one foot in the ped
Financial markets are complex processes where investors interact to set prices. We present a framework for option valuation under imperfect information, taking risk neutral parameter uncertainty into account. The framework is a direct generalization of the existing valuation methodology. Many investors base their decisions on mathematical models that have been calibrated to market prices. We argue
To ascertain the epigenomic features, i.e., the methylation, non-coding RNA, and gene expression patterns, associated with gain of i(12p) in Pallister-Killian syndrome (PKS), we investigated single cell clones, harboring either disomy 12 or tetrasomy 12p, from a patient with PKS. The i(12p)-positive cells displayed a characteristic expression and methylation signature. Of all the genes on 12p, 13%
This brief presents a low-complexity system for digitally assisting a channel select filter (CSF) to mitigate both even- and odd-order nonlinearities. The proposed solution is scalable and can be utilized for nonlinearity mitigation in different analog transceiver blocks. The system consists of an auxiliary path with a low-resolution analog to digital converter (ADC) enabling digital recreation an
The production of single- and multi-photon events has been studied in the reaction e(+) e(-) --> gamma(gamma) + invisible particles. The data collected with the DELPHI detector during the years 1999 and 2000 at centre-of-mass energies between 191 GeV and 209 GeV was combined with earlier data to search for phenomena beyond the Standard Model. The measured number of light neutrino families was cons
This is the first report of the Twin Mom Study, an investigation. of three hypotheses concerning influences on maternal adjustment. These hypotheses concern the role of the marital and parent-child relationships in mediating genetic influences on maternal adjustment and on the importance of the mothers' marital partners as a specifiable source of influences on their adjustment not shared with thei
Popular Abstract in Swedish Principen för biologisk vattenreningsteknik är att mikroorganismer används för att bryta ner olika typer av föroreningar. Då det finns en stor mängd olika sorters mikroorganismer, kan flera typer av nedbrytningsmekanismer och processutformningar utnyttjas för olika krav och syften. Nackdelen med biologisk vattenreningsteknik är dock att den är känslig för störningar ochThe aim of the thesis was to investigate how different abiotic and biotic parameters may affect microorganisms and the process performance in various biological wastewater treatment systems. The type of carbon source in the influent wastewater may have a profound effect on the composition and the activity of denitrifying activated sludge bacteria in nutrient removal. Of four investigated carbon s
The purpose of the Gramte program is to meet the needs of university students who feel that they are not mastering the grammatical terminology needed for studying linguistics or foreign languages. In all learning contexts it is important to have the adequate background knowledge. This is even more crucial when it concerns the basic concepts and terminology which will be used by the teachers during
