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Therapeutic antibodies are the fastest growing class of drugs but suffer from a crowded target-space where many antibodies, against a few targets, are developed in parallel. The aim of this thesis is to find methods to enable discovery of novel antibody-target combinations and thereby increase the target-space. A strategy to achieve this is to use phage display antibody libraries and selection on
BACKGROUND: Global inequalities in access to health care are reflected in differences in cancer survival. The CONCORD programme was designed to assess worldwide differences and trends in population-based cancer survival. In this population-based study, we aimed to estimate survival inequalities globally for several subtypes of childhood leukaemia.METHODS: Cancer registries participating in CONCORD
Del(5q) myelodysplastic syndromes defined by the International Prognostic Scoring System as low- or intermediate- 1-risk (lower-risk) are considered to have an indolent course; however, recent data have identified a subgroup of these patients with more aggressive disease and poorer outcomes. Using deep sequencing technology, we previously demonstrated that 18% of patients with lower-risk del(5q) m
The responses of 44 nociceptive neurones in the lumbar dorsal horn evoked by controlled mechanical stimulation of the skin, with or without conduction block in myelinated afferent fibres, were studied in the halothane-anaesthetized rat, in order to evaluate the effects of impulses in cutaneous nociceptive C fibres on dorsal horn neurones. Continuous non-noxious pinch of the skin evoked a short-lat
PurposeTo provide an employee perspective on ambassadorship in the context of corporate communication, the purpose of this paper is to explore how employees relate to and experience ambassadorship.Design/methodology/approachThe study has a qualitative approach, and the empirical material consists of semi-structured interviews with, and focus groups of, employees of seven organizations in both the
Intercalation of very long molecules into the structure of multi-layered graphene oxide (GO) was studied using example of 1-hexadecanol (C16), an alcohol molecule with 16 carbon atoms. Brodie graphite oxide (BGO) immersed in excess of liquid C16 just above the melting point shows expansion of c-unit cell parameter from ∼6 Å to ∼48.76 Å forming a structure with two densely packed layers of C16 mole
Atomic diusion and mixing processes in stellar interiors influence the structure and the surface composition of stars. Some of these processes cannot yet be modelled from the first principles, and they require calibrations. This limits their applicability in stellar models used for studies of stellar populations and Galactic evolution. Aims. Our main goal is to put constraints on the stellar struc
Objectives: The aim of this feasibility study was to evaluate the added value of contrast-enhanced mammography (CEM) in preoperative staging of malignant breast lesions, beyond standard assessment with digital mammography and ultrasound, as a base for a future prospective randomized trial. Materials and methods: Forty-seven patients, with confirmed or strongly suspected malignant breast lesions af
Cartridge cases are often the sole items left behind after a shooting incident and DNA traces from these can identify persons connected to the shooting. However, the chance of retrieving usable DNA profiles from cartridge cases is limited, due to the low amounts of deposited DNA and subsequent DNA loss associated with the firing process. In the current study, we set out to increase the DNA recover
To clarify whether metabolic control and β‐cell function deteriorate with increasing duration of diabetes, we investigated in a cross‐sectional study Type 2 diabetic patients in an area‐based population. Type 2 diabetic patients (n = 231: 112 males, 119 females) were identified by age at onset > 35 years, fasting levels of C‐peptide > 0.04 nmol l−1, and absence of islet cell antibodies. Body weigh
Introduction: Breathlessness is common in the population, especially in women and associated with adverse health outcomes. Obesity (body mass index (BMI) >30 kg/m2) is rapidly increasing globally and its impact on breathlessness is unclear. Methods: This population-based study aimed primarily to evaluate the association of current BMI and self-reported change in BMI since age 20 with breathlessnes
The causes and extent of regional inequality in the process of economic growth are at the core of historical economic research. So far, much attention has been devoted to studying the role of industrialization in driving regional divergence. However, empirical studies on relatively unequal countries such as Italy and Spain show that inequality was already high at the outset of modern industrializa
Complete blood counts with red blood cell determinants associate with reduced beta‐cell function in seroconverted Swedish TEDDY children Endocrinol Diab Metab. 2021;4:e00251. | 1 of 10 https://doi.org/10.1002/edm2.251 wileyonlinelibrary.com/journal/edm2 Received: 24 November 2020 | Revised: 1 March 2021 | Accepted: 22 March 2021 DOI: 10.1002/edm2.251 O R I G I N A L R E S E A R C H A R T I C L
https://www.teddy.lu.se/sites/teddy.lu.se/files/2022-10/133_MP239_Salami_EndoDiabMetab_2021.pdf - 2026-06-06
24 March 2021 Call for applications for university-wide funding – Interdisciplinary projects focusing on Agenda 2030 and sustainable development. Questions and answers. Part I. Frequently asked questions on the call. Agenda 2030 has a wide scope. Do you have any priorities? The call will not make any priorities within Agenda 2030. The broad concept of sustainable development is covered in the ca
https://www.staff.lu.se/sites/staff.lu.se/files/2021-03/FAQ%2020210324.pdf - 2026-06-06
Mental health and support | Student website LTH Skip to main content This site uses cookies to enhance the user experience. By continuing to use the site you agree that cookies are used according to our Cookie Policy (on the website of LTH) . Essential cookies These cookies are necessary for the website to function and cannot be turned off in our systems. These cookies do not store any personally
https://www.student.lth.se/english/support-and-services/mental-health-and-support/ - 2026-06-06
Top 10 reasons to study at LTH | LTH, Faculty of Engineering Skip to main content We use cookies and other tracking technologies to improve the user experience on our website, to show you personalised content and targeted ads, and to analyse our website traffic. Cookie Policy . Essential cookies These cookies are necessary for the website to function and cannot be turned off in our systems. These
https://www.lth.se/english/study-at-lth/top-10-reasons-to-study-at-lth/ - 2026-06-06
The student template in brief The student template in brief The first page in the template is a page you can use (make sure that page has no notes!) in the event of technical difficulties. If you are to publish your presentation on Canvas, the law requires you to make it accessible. Adapting for accessibility is important as it enables people with different abilities to participate fully. Check an
https://www.lth.se/fileadmin/lth/bibliotek/PPT_mall_student_16-9__eng_.pptx - 2026-06-06
Background. Seeking to clarify the parent-offspring transmission of Major Depression (MD) and type I Bipolar Disorder (BD), we examined offspring MD and BD risk in five informative parental pairs: Unaffected x MD, Unaffected x BD, MDxMD, MDxBD and BDxBD. Methods. We identified 289,637 individuals born in Sweden 1970-1990, followed through 2018, from parents with MD and/or BD identified from Swedis
