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The increased demand, driven by a growing population and changing dietary habits, has created immense pressure on agroecosystems throughout the globe. In semi-arid areas, this increased pressure has led to excessive use of agrochemicals in agriculture, which poses a threat of potentially toxic metal (PTM) contamination in agricultural soils. PTMs in agricultural soils result in significant environ

Shiga toxin-producing Escherichia coli O157:H7 is a virulent strain causing severe gastrointestinal infection, hemolytic uremic syndrome and death. To date there are no specific therapies to reduce progression of disease. Here we investigated the effect of pooled immunoglobulins (IgG) on the course of disease in a mouse model of intragastric E. coli O157:H7 inoculation. Intraperitoneal administrat

Delivery of antigenic peptides to antigen presenting cells (APCs) such as dendritic cells (DCs) using monoclonal antibodies (mAbs) is an attractive approach to evoke antigen-specific T cell activation and improve drug efficacy. Peptide linkage to mAbs has previously been achieved through genetic fusion, chemical conjugation, nano-engineered platforms and high affinity peptides. In this study, we h

Introduction: Due to the high cost and complexity, the oral glucose tolerance test is not adopted as the screening method for identifying diabetes patients, which leads to the misdiagnosis of patients with isolated post-challenge hyperglycemia (IPH), that is., patients with normal fasting plasma glucose (<7.0 mmoL/L) and abnormal 2-h postprandial blood glucose (≥11.1 mmoL/L). We aimed to develop a

Globalisation is characterised not only by long-distance exchange by commodities and people, but also by a microbial unification of the world (une unification microbienne du monde), as was described by Emmanuel Le Roy Ladurie in the 1970s. Proof of microbial unification can be seen through the dramatic consequences of the Black Death in the 14th century CE as well as the Covid-19 pandemic, which i

Keynote paper The point of departure for this lecture lies in the insight that tourism research is uniquely positioned at the juncture of applied and scholarly research. Drawing upon work I have conducted in the realms tourism and leisure study, the lecture strives to problematize the practice of ethnography as a method and raise questions concerning the opportunity research in the fields of tour

Socially Engaged Buddhism: Faith‐inspired drivers of social and political change Chair & introduction. Monica Lindberg Falk, Centre for East and South-East Asian Studies, Lund University, Sweden. This session invites paper that address issues related to socially engaged Buddhism. The Buddhist institutions have always been important actors in society; however, the monks’ and the nuns’ roles h

Background. Anti-glomerular basement membrane (anti-GBM) disease often results in end-stage renal failure despite therapy with plasma exchange and immunosuppressive drugs. The newly discovered streptococcal enzymes IgG-degrading enzyme of S.pyogenes (IdeS) and endoglycosidase S (EndoS) act with remarkable specificity on circulating IgG. In this study, we investigate their ability in vivo to preven

The function of cultured mast cells may depend on genetic or environmental influence on the stem cell donor. This study investigates whether asthma or atopy in the donor influenced the growth and sensitivity of mast cells cultured from patients with asthma and healthy controls under identical conditions. Mast cells were cultured from peripheral blood from twelve patients with an objectively confir

Abstract Through the use of chimeric CXCR4/CCR5 receptors we have previously shown that CCR5-tropic (R5) HIV-1 isolates acquire a more flexible receptor use over time, and that this links to a reduced viral susceptibility to inhibition by the CCR5 ligand RANTES. These findings may have relevance with regards to the efficacy of antiretroviral compounds that target CCR5/virus interactions. Compartme

Våld i nära relationer har under många år varit och är än idag ett stort samhällsproblem. Det är ett problematiskt område som troligtvis har ett stort mörkertal och därmed är svårt att upptäcka. I vissa fall kanske våld i nära relationer inte upptäcks förrän det är för sent. Vilka möjligheter har brottsoffer för våld i nära relationer att freda sig själv och sin familj? Syftet med denna uppsats ärDomestic violence has always been a major social problem and still is. This kind of crime is often characterized by hidden statistics which makes it difficult to detect in many cases. What possibilities do victims of domestic violence have to protect themselves and their families? The purpose of this thesis is to examine the possibility to use preventive self-defense in cases of domestic violence.

In research on Birka strong focus has since long been directed towards long-distance contacts with Western as well with and Northeastern Europe (todays Russia, Belarus and Ukraine). The great attention paid to west- and east European contacts has likely contributed to that contacts with Finland have fallen out of the discussions. However as seen from studies of the pottery in Birka the Baltic Finn

In the current work, cationic polymers functionalized with N-alicyclic quaternary ammonium (QA) cations were synthesized and characterized as potential hydroxide exchange membranes (HEMs) for application in fuel cells. Three different polymers, namely poly(arylene ether sulfone), spiro-ionene and poly(arylene alkylene), were explored as polymer backbones for the HEMs. Various mono- and spirocyclic

Background: Cardiopulmonary resuscitation (CPR) has the potential to save many lives. Used indiscriminately though, it may be harmful and not in the best interest of the patient. An advance directive to refrain from resuscitation in selected patients is probably not uncommon in Sweden, but guidelines ruling this are still generally lacking. This study was performed to evaluate the use and document

The competitive position achieved by the Japanese and Western industries during the 1970s to mid-1990s, and 1980s to mid-1990s, respectively, derived from understanding, implementing, and developing Total Quality Management (TQM) as a comprehensive management philosophy. Several research and/or company studies provided evidence of this development and its impact on leading companies’ efficiency an

De vanligaste kontakterna under vikingatiden ur ett svenskt perspektiv gick österut. Miljontals islamiska mynt flödade in i Skandinavien från Nordafrika, kalifatet och det samanidiska herraväldet i Centralasien. Deras ursprung varierade, och silverströmmens kronologi gör det möjligt att beskriva föränderliga relationer mellan aktörerna. Några välkända artefakter från samma riktning kom till Skandi

The feasibility of different options to reduce the risks of climate change has engaged scholars for decades. Yet there is no agreement on how to define and assess feasibility. We define feasible as “do-able under realistic assumptions.” A sound feasibility assessment is based on causal reasoning; enables comparison of feasibility across climate options, contexts, and implementation levels; and ref

Group A streptococcus (GAS) is a highly adapted, human-specific pathogen that is known to manipulate the immune system through various mechanisms. GAS’ M protein constitutes a primary target of the immune system due to its spatial configuration and dominance on the bacterial surface. Antibody responses targeting the M protein have been shown to favor the conserved C region. Such antibodies (Abs) c