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Variation at ABO histo-blood group and FUT loci and diffuse and intestinal gastric cancer risk in a European population
ABO blood serotype A is known to be associated with risk of gastric cancer (GC), but little is known how ABO alleles and the fucosyltransferase (FUT) enzymes and genes which are involved in Lewis antigen formation [and in Helicobacter pylori (H. pylori) binding and pathogenicity] may be related to GC risk in a European population. The authors conducted an investigation of 32 variants at ABO and FU
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The activation of transcription of host fucosyltransferase genes during Herpes Simplex Virus infection is based on a common mechanism in fibroblasts and T-cells
Hur påverkar Herpes Simplex Virus vilka gener som uttrycks i den infekterade cellen? Herpes Simplex Virus har förmågan att ändra vilka gener som uttrycks i en infekterad cell. Detta gör att viruset får verktyg att ändra på proteinerna på den infekterade cellens yta. Vi har undersökt hur den lyckas med detta genom att blockera olika signalvägar och mäta hur mycket RNA av olika gener som produceratHerpes Simplex Virus type 1 (HSV-1) is a virus infecting over 90 % of the population. It causes latent infections in nerve cells and can upon reactivation travel along the neurons and cause lytic infections with painful blisters as a result. HSV-1 infects multiple cell types, fibroblasts and T-cells among others. During infection HSV-1 is known to downregulate the transcription of many of the gene