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Identification of a Ser/Thr cluster in the C-terminal domain of the human prostaglandin EP4-R essential for agonist-induced beta-arrestin1 recruitment that differs from the apparent principal phosphorylation site.

hEP4-R (human prostaglandin E2 receptor, subtype EP4) is a Gs-linked heterotrimeric GPCR (G-protein-coupled receptor). It undergoes agonist-induced desensitization and internalization that depend on the presence of its C-terminal domain. Desensitization and internalization of GPCRs are often linked to agonist-induced b-arrestin complex formation, which is stabilized by phosphorylation. Subsequentl

Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases

Tec family protein tyrosine kinases (TFKs) play a central role in hematopoietic cellular signaling. Initial activation takes place through specific tyrosine phosphorylation situated in the activation loop. Further activation occurs within the SH3 domain via a transphosphorylation mechanism, which for Bruton's tyrosine kinase (Btk) affects tyrosine 223. We found that TFKs phosphorylate preferential

Persistent organochlorine pollutants in children working at a waste-disposal site and in young females with high fish consumption in Managua, Nicaragua

No difference between daily and weekly pin site care: a randomized study of 50 patients with external fixation.

Magnetic phases of one-dimensional lattices with 2-4 fermions per site

The conserved WW-domain binding sites in Dystroglycan C-terminus are essential but partially redundant for Dystroglycan function

Accurate Predictions of Nonpolar Solvation Free Energies Require Explicit Consideration of Binding-Site Hydration

Continuum solvation methods are frequently used to increase the efficiency of computational methods to estimate free energies. In this paper, we have evaluated how well such methods estimate the nonpolar solvation free-energy change when a ligand binds to a protein. Three different continuum methods at various levels of approximation were considered, viz., the polarized continuum model (PCM), a me

Available energy and energy balance closure at four coniferous forest sites across Europe

The proper way of dwelling at the Early Neolithic gathering site of Almhov in Scania, Sweden

Small Scale Reformers for on-site Hydrogen Supply

Effects on rural House Sparrow and Tree Sparrow populations by experimental nest-site addition

Do quantum mechanical energies calculated for small models of protein-active sites converge?

Arabidopsis PDK1: identification of sites important for activity and downstream phosphorylation of S6 kinase

Localization of phosphatidylserine binding sites to structural domains of factor X-a

Plant species diversity as a driver of early succession in abandoned fields: a multi-site approach

Succession is one of the most studied processes in ecology and succession theory provides strong predictability. However, few attempts have been made to influence the course of succession thereby testing the hypothesis that passing through one stage is essential before entering the next one. At each stage of succession ecosystem processes may be affected by the diversity of species present, but th

Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in vitro

Identification of Noncollagenous Sites Encoding Specific Interactions and Quaternary Assembly of alpha 3 alpha 4 alpha 5(IV) Collagen IMPLICATIONS FOR ALPORT GENE THERAPY

Tracking taphonomy. Analysis of skeletal remains from wild boar (Sus scrofa) and red deer (Cervus elaphus) from Mesolithic sites in Scania, Southern Sweden

Determination of NO adsorption sites on Pd(100) using core level photoemission and low energy electron diffraction

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