Sökresultat

As the Human Proteome Project has outlined currently many research groups worldwide dedicated resources to focus on the completion of the human proteome catalogue. According to the project directives, not only all products of ca. 20,300 protein coding genes should be identified but also at least one splicing variant, one single nucleotide polymorphism product and some major post-translational modi

Statement of Purpose: Chronic lung diseases are one of the major health problems that cause death and disability. Approximately 65 million people suffer from chronic lung diseases, and the number of patients is predicted to increase worldwide 1 . Lung transplantation is the only available treatment option for patients at end-stage disease. However, there is a chronic shortage of donor organs, re

Statement of Purpose: Many chronic pulmonary diseases, including idiopathic pulmonary fibrosis (IPF), pulmonary hypertension (PH) and chronic obstructive pulmonary disease (COPD), are complex and poorly understood. While great progress has been made to elucidate the cellular and molecular pathways underlying these diseases, treatment options remain limited. The dynamic alterations in mechanical pr

This is the Dutch contribution to the book Implementing Key BEPS Actions: Where Do We Stand? Discussed are amongst others measures against hybrid mismatch arrangements, CFC rules, interest deductions, countering harmful tax practices, transfer pricing and the MLI.

Forskare vid Lunds universitet har upptäckt ett cellskelett som ger struktur åt mito-kondrierna, cellens energifabriker. Skelettet är nödvändigt för mitokondriernas funktion, men forskarna fann även att cancerceller trots defekter utnyttjar skelettet för att kunna bibehålla sin energiproduktion – och därigenom överleva. Cellskelettet i mitokondrierna fungerar ungefär som ett armeringsnät och hjälp

Bone is a complex hierarchical structure mainly comprising of a matrix of collagen and hydroxyapatite. The main physiological functions of bone include regulating skeletal remodeling, calcium homeostasis and providing a congenial environment to the bone marrow cells to reside and these physiological processes are intricately regulated by various cell types and biomolecules. During trauma to the sk

Sweden’s child welfare services are characterised by intra-organisational specialisation and collaboration with Barnahus as a standard procedure in cases of child abuse. This chapter examines what happens with social workers’ risk assessments when they are both filtered internally at different units and in relation to Barnahus and a criminal law-oriented logic. Various organisational tensions are

The remaining lifetime of concrete structures subjected to chloride-induced corrosion has been studied in many papers. However, few studies so far consider explicitly experiences from case studies, jointly several corrosion mechanisms and a system perspective. This paper introduces a methodology to evaluate the time-dependent system reliability for concrete bridges subjected to reinforcement corro

In this paper, we aggregate, analyze, and exemplify several metrics for the information value. The metrics vary by absolute value, normalizations, or full probabilistic quantification. The normalization of the information value encompasses the division by (1) the expected and maximized utility of the base scenario (usually without additional information), (2) by the system performance, or (3) by t

We propose a simple architecture for implementing supervised neural network models optically with photorefractive technology. The architecture is very versatile: a wide range of supervised learning algorithms can be implemented including mean-field-theory, backpropagation, and Kanerva-style networks. Our architecture is based on a single crystal with spatial multiplexing rather than the more commo

This paper examines the influence of artificial intelligence (AI) on recent operatic practice, exploring its potential to affect the development of the genre from the artist’s perspective. While opera has historically evolved in tandem with technological advancements, the integration of AI raises important questions about its function within the operatic toolbox and its relation to the genre’s cor

We consider simple approximations of variances and covariances for order statistics from the standard extreme value distribution. Exact values and simulation results of the variances and covariances for certain sample sizes are used to determine the validity of the suggested approximations.

Abstract in French Beaucoup d’hommes et de femmes aymara affirment que le savoir humain, transmis par la langue, n’est qu’un pur ‘siwsawi’, i.e. des paroles, des opinions, des points de vue, des jugements d’individus particuliers. Ainsi, il s’agit d’un savoir particulier ; c’est une connaissance concernant l’opinion de certaines personnes, rien de plus. Ceci est, de manière significative, différenMany Aymara men and women claim that human knowledge as transmitted through language is pure ‘siwsawi’, i.e. talk, opinions, views and judgments of particular individuals. As such it is knowledge of a particular kind; it is knowledge concerning the opinions of other humans, nothing else. It is thereby significantly different from the non-linguistic, experiential knowledge that is lived-through and

A number of Extremely Large Telescopes for visual-infrared and adjacent wavelengths are in various degrees of progress. All have primary mirrors with equivalent diameters larger than 20 m and are intended for operation with adaptive optics systems. We discuss several ELT observing parameters as functions of wavelength. Stellar energy distributions and atomic line spectra are inspected as are the t