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The effects of flunarizine, a calcium entry blocker, were evaluated in a long-term survival model of ischemia in rats. One group of animals received the drug orally at 24 and 4 h prior to the insult (40 mg·kg-1·dose-1). Another group was given flunarizine following the insult, intravenously at 5 min (0.1 mg·kg-1), and orally at 8 and 24 h (40 mg·kg-1·dose-1). A third group received the solvent for

Postoperative morbidity after hysterectomy was studied prospectively in 229 consecutive patients in our departments. The incidence of alcohol abuse (> or = 60 gm of alcohol daily) and moderate drinking (between 25 and 60 gm of alcohol daily) was 6.5% for each. When compared with the moderate drinkers and the control group, the alcohol abusers developed significantly more complications (80% versus

In Sweden 1600 patients/year survive cardiac arrest (30-day survival). Post-resuscitation care is complex and aims to stabilize organ function with focus on preventing secondary brain injury. In 2021 The European Resuscitation Council (ERC) and European Society of Intensive Care Medicine (ESICM) published joint guidelines on post-resuscitation care. In this article the Swedish Resuscitation Counci

In 1524, Petrus Apianus published two closely related works—one the Latin Cosmographicus liber, aimed at an educated audience of international readers, and the other, Ein kunstlich Instrument, a shorter, more practical book for those who could read German but had no Latin. Both books nevertheless make use of most of the same instruments, including Apianus’ early volvelles. Most of these instrument

The aim of the study reported in this paper is to investigate how students understand continuity and differentiability during and after a calculus course. The students’ choices of representations, both claimed and acted, were also studied. The study is part of a larger study of four student groups taking a calculus course. 207 students answered a questionnaire during the course and of them, 11were

This article studies the maximum likelihood estimates of magnitude and scale parameters for a Gaussian process of Ornstein-Uhlenbeck type used to model a deterministic function that does not have to be a realisation of an Ornstein- Uhlenbeck process. Specifically, we derive explicit expressions for the limiting values of the maximum likelihood estimates as the number of observations increases. The

We prove the nonexistence of two-dimensional solitary gravity water waves with subcritical wave speeds and an arbitrary distribution of vorticity. This is a longstanding open problem, and even in the irrotational case there are only partial results relying on sign conditions or smallness assumptions. As a corollary, we obtain a relatively complete classification of solitary waves: they must be sup