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Gaucher disease type 1 (GD type 1) and Diamond-Blackfan anemia (DBA) are rare genetic disorders affecting the hematopoietic system and routinely treated by administration of drugs with variable clinical efficacy. Though effective in alleviating disease symptoms in large cohorts of patients, these treatment options have the major drawback of being non-curative. Currently, bone marrow transplantatio
Popular Abstract in Swedish Avhandlingen är indelad i två delar. I den första delen studeras hur kommunikation påverkar utfall i strategiska situationer, så kallade spel. Den andra delen studerar individers riskpreferenser. Metodologiskt förlitar sig avhandlingen till största delen på ekonomiska experiment. I kapitel 2 till 4, som är författade tillsammans med Ola Andersson, studeras effekterna aThis thesis is divided into two distinct parts. The first part studies communication in games and the second part investigates individual decision making under risk. Chapters 2 – 4, co-authored with Ola Andersson, investigate communication and renegotiation in dynamic games. In Chapter 2, Bertrand supergames with non-binding communication are used to study price formation and stability of collus
Popular Abstract in Swedish Sammanfattning Teknik är alltid skapad för en förväntad brukare i ett antaget sammanhang. Inom kommersiell luftfart är dessa antaganden när det gäller design tydliga. Såväl besättning som utrustning är certifierad för en viss typ av operationer i enlighet med flygplanets drifthandbok. Trots denna genomtänkta definition av användare i sitt sammanhang händer det ändå attAbstract Technology is always designed for an assumed user in an assumed context. In commercial aviation, these design assumptions are clearly spelt out in that both crew and equipment are certificated for a specific operation as stated in the aircraft flight manual. Despite this well defined user context, the designed-for and the real contexts often differ enough so that adaptations of working p
This study of maxillary sinus reconstruction in conjunction with insertion of endosseous implants included 99 patients. Two separate surgical methods were applied; a one-staged strategy (n=49) and a two-staged strategy (n=50). The aims were to compare two different strategies concerning implant and prosthetic construction survival. Differences in positioning and angulation of the inserted implants
A new palaeoenvironmental record of the post-glacial history of the southern Baltic Sea (~14 ka to present) is presented. During this period, large water level and salinity changes occurred in the Baltic Basin due to opening and closing of connections to the North Atlantic. Previous attempts to establish a detailed chronology for these palaeoenvironmental changes have been conducted mainly in coas
Chemistry and Human Health, Division VII of the International Union on Pure and Applied Chemistry (IUPAC), provides guidance on risk assessment methodology and, as appropriate, assessment of risks to human health from chemicals of exceptional toxicity. The aim of this document is to describe dose-response relationships for the health effects of low-level exposure to cadmium, in particular, with an
According to the International Energy Agency about 14% of greenhouse gases (GHG) are generated by the transportation sector globally and this share is estimated to increase to 50% by 2030. At the same time consumption of mobility is continuously increasing, making it one of the most crucial sectors to focus on for sustainable consumption. Several measures and policies are being implemented to redu
Popular Abstract in Swedish Syftet med avhandlingen var att utarbeta en vård- och omvårdnadsmodell som förbättrar livskvalitet och hälsa hos svenska kvinnor med Irritable Bowel Syndrome (IBS). Avhandlingen består av 4 delstudier: Delstudie 1. Kvinnor med IBS upplevelse av en god livskvalitet. Delstudie 2. Utbildning av kvinnor med IBS. Delstudie 3. Hälsoaspekter i relation till användandet av Irritable Bowel Syndrome (IBS) is a common, worldwide, functional disorder affecting a significant number of people, predominantly women. Etiology and pathophysiology is insufficiently understood, but the research over the past decade has led to progress in the understanding of IBS, and it is generally accepted that the symptoms of IBS are multidetermined. However, management of IBS is still a cha
BACKGROUND: Abiraterone acetate plus prednisone significantly improved radiographic progression-free survival compared with placebo plus prednisone in men with chemotherapy-naive castration-resistant prostate cancer at the interim analyses of the COU-AA-302 trial. Here, we present the prespecified final analysis of the trial, assessing the effect of abiraterone acetate plus prednisone on overall s
Main recommendations: Endoscopic mucosal resection (EMR) is the standard of care for the complete removal of large (≥ 10mm) nonpedunculated colorectal polyps (LNPCPs). Increased detection of LNPCPs owing to screening colonoscopy, plus high observed rates of incomplete resection and need for surgery call for a standardized approach to training in EMR. 1 Trainees in EMR should have achieved basic co
Aims: Coronary microvascular dysfunction (CMD) has been proposed as an important pathophysiological mechanism in Takotsubo syndrome (TTS). Our aims were (i) to evaluate and compare levels of CMD in patients with TTS and patients with ischaemia and no obstructive coronary arteries (INOCA) and (ii) to investigate associations between CMD and clinical parameters, left ventricular function, and corona
A numerical model has been used to simulate the conditions observed during the ACE-2 Hillcloud experiment and to study the processes which may be taking place. The model incorporates gas phase chemistry of sulphur and nitrogen compounds upstream of the cloud, and the interaction of aerosol, precursor trace gases and oxidants within the cloud. Gas phase and aerosol inputs to the model have been pro
Background: To support a victim of violence and establish the correct penalty for the perpetrator, it is crucial to correctly evaluate and communicate the severity of the violence. Recent data have shown these communications to be biased. However, computational language models provide opportunities for automated evaluation of the severity to mitigate the biases. Objective: We investigated whether
Acute respiratory distress syndrome (ARDS) is a life-threatening, high mortality pulmonary condition characterized by acute lung injury (ALI) resulting in diffuse alveolar damage. Despite progress regarding the understanding of ARDS pathophysiology, there are presently no effective pharmacotherapies. Due to the complexity and multiorgan involvement typically associated with ARDS, animal models rem
Denna framställning behandlar den komplexa relationen mellan barn, vårdnadshavare och samhälle när det kommer till barn i hälso- och sjukvården. I framställningen ställs frågan vem som egentligen bestämmer om barnets hälso- och sjukvård. Utgångspunkten i svensk hälso- och sjukvård är att patienten har självbestämmanderätt, det vill säga rätt att samtycka till, eller motsätta sig, erbjudna hälso- This thesis is about the complex relationship between children, guardians and society regarding children in Swedish healthcare. The thesis poses the question who has the right to decide on children’s health- and medical care. Swedish health care is based on the patients’ right to determine about one’s own health- and medical care. That is, the right to consent to, or oppose, offered health- and m
The 5th generation (5G) has recently specified a new spectrum range, FR2- 5G New Radio (5G-NR), to provide higher spectral efficiency and channel capacity for ubiquitous cellular connectivity where the user ends can be in various types such as picocell stations, sensor nodes, cloud servers, hand-held devices, and so on. Due to the advantage of phased array antennas in performing beam-forming, and
The aim of the user related assessment was to study perceived advantages, disadvantages, usefulness, trust, acceptance, willingness to have and pay for the driver assistance system: Enhanced Dynamic Pass Predictor developed by BMW within the framework of the SECONDS subproject. Due to restrictions of driving by naïve drivers in real traffic conditions, assessment activities were limited to a demon
In this chapter, I discuss some effects on the ‘creative classes’ in Sweden and Scandinavia due to developments during roughly the last decade. In this period, a majority of the feature film making but also some documentary and TV-production has moved away from Stockholm, the capital, to newly established, regional production centres. A similar process has been going on for a while in other parts
Background: Many people are tempted to start their own business. The personal driving force varies but in most cases it’s all about making money. But it doesn’t always have to be for that reason alone. Maybe you want to take initiatives to changes, separate yourself from the crowd and take risks. Many people also like that they can be their own boss. These driving forces led to our own interests i
Mild to moderate renal impairment affects 10% of the general population. Renal impairment is difficult to detect because of the lack of symptoms, but it can be estimated by calculating the estimated glomerular filtration rate (eGFR) on the basis of plasma creatinine and/or cystatin C concentrations. Chronic kidney disease (CKD) is associated with an increased risk of development of cardiovascular
