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Popular Abstract in Swedish Denna avhandling studerar kronisk venös sjukdom i nedre extremiteten, något som drabbar mellan 30 – 50% av den vuxna populationen i västvärlden. En viktig faktor i utredningen av kronisk venös sjukdom är s.k. reflux, vilket innebär att venklaffar inte förmår hindra blodet att rinna i ”fel” riktning. Därmed minskar möjligheten till ventryckssänkning i samband med arbete,Controversies exist regarding both what is required for a proper diagnosis of chronic venous disease (CVD), and what treatment to offer patients. An objective evaluation is mandatory to individualize treatment. This thesis deals with the evaluation of patients with CVD with specific emphasis on CEAP classification (C; clinical, E; etiological, A; anatomical, P; pathophysiological), symptoms and si

Mechanical properties and rate of ATP breakdown (JATP) have been determined in the chemically skinned guinea-pig taenia coli at 22 degrees C. The influence of varied [Ca2+], [Mg ATP] and muscle length were investigated. The shortening response after a step decrease in force (isotonic quick release) was highly curvilinear in the first 100-200 ms. This effect was shown to be a time-dependent respons

Accumulated carbon uptake, apparent quantum yield (AQY) and light-saturated net CO2 assimilation (A(sat)) were used to assess the responses of photosynthesis to environmental conditions during spring for three consecutive years. Whole-tree chambers were used to expose 40-year-old field-grown Norway spruce trees in northern Sweden to an elevated atmospheric CO2 concentration, [CO2], of 700 mu mol C

Context. Observational evidence indicates that the orbits of extrasolar planets are more various than the circular and coplanar ones of the solar system. Planet-planet interactions during migration in the protoplanetary disc have been invoked to explain the formation of these eccentric and inclined orbits. However, our companion paper (Paper I) on the planet-disc interactions of highly inclined an

Aim: To investigate the associations between major foods and dietary fibre with subtypes of stroke in a large prospective cohort. Methods and results: We analysed data on 418 329 men and women from nine European countries, with an average of 12.7 years of follow-up. Diet was assessed using validated country-specific questionnaires which asked about habitual intake over the past year, calibrated us

A numerical model has been used to simulate the conditions observed during the ACE-2 Hillcloud experiment and to study the processes which may be taking place. The model incorporates gas phase chemistry of sulphur and nitrogen compounds upstream of the cloud, and the interaction of aerosol, precursor trace gases and oxidants within the cloud. Gas phase and aerosol inputs to the model have been pro

Changes in the geometry of ocean meridional overturning circulation (MOC) are crucial in controlling past changes of climate and the carbon inventory of the atmosphere. However, the accurate timing and global correlation of short-term glacial-to-deglacial changes of MOC in different ocean basins still present a major challenge. The fine structure of jumps and plateaus in atmospheric and planktic r

Sepsis causes major morbidity and mortality worldwide. There is wide consensus that biomarkers have an important role in sepsis research and patient care. Heparin-binding protein (HBP) is a neutrophil-derived, proinflammatory and vascular permeability-inducing protein and a promising novel sepsis biomarker. In this thesis, we investigate some aspects of the prognostic accuracy and added value of s

Mild to moderate renal impairment affects 10% of the general population. Renal impairment is difficult to detect because of the lack of symptoms, but it can be estimated by calculating the estimated glomerular filtration rate (eGFR) on the basis of plasma creatinine and/or cystatin C concentrations. Chronic kidney disease (CKD) is associated with an increased risk of development of cardiovascular

Aims: We applied near-infrared-spectroscopy (NIRS) to measure absolute frontal cerebral tissue oxygen saturation (SctO2) during head-up tilt test (HUT) in patients investigated for unexplained syncope.Methods and results: Synchronized non-invasive beat-to-beat haemodynamic monitoring, ECG, SctO2 (NIRS; normal range: 60-80%), and peripheral oxygen saturation (left hand, SpO2) were applied during HU

Background: Dextran-70 is a more potent plasma volume expander than albumin but use has beenhampered because of it´s antithrombotic properties. However, also albumin has antithromboticproperties and little is known about relative effects of these two colloids on coagulation in-vivo whencontrolling for differences in efficacy as plasma volume expanders. Aim: Compare effects of dextran-70 and albumiBACKGROUND: Dextran-70 is a more potent plasma volume expander than albumin but use has been hampered because of it's antithrombotic properties. However, also albumin has antithrombotic properties and little is known about relative effects of these two colloids on coagulation in-vivo when controlling for differences in efficacy as plasma volume expanders.AIM: Compare effects of dextran-70 and albu

The Amazon Basin is a unique region to study atmospheric aerosols, given their relevance for the regional hydrological cycle and the large uncertainty of their sources. Multi-year datasets are crucial when contrasting periods of natural conditions and periods influenced by anthropogenic emissions. In the wet season, biogenic sources and processes prevail, and the Amazonian atmospheric composition

Aim: To explore the correlation between fistula development and urinary flow measurements after hypospadias repair with emphasis on patients with urethrocutaneous fistula complications and to identify risk factors for fistula development. Methods: Urinary flow was examined in boys operated on for hypospadias. Outcome of maximum urinary flow (ml/s) (Qmax), voided volume for age (ml) (Volume), and p

In this chapter, the pathophysiology and neurochemical pathology of epileptic brain damage is discussed on the basis of an integrative approach in which a comparison is made to cell necrosis resulting from ischemia and hypoglycemia. Two main questions are asked. First, is the brain damage resulting from these three disorders of cerebral energy metabolism similar in distribution and structural char

BACKGROUND: Abiraterone acetate plus prednisone significantly improved radiographic progression-free survival compared with placebo plus prednisone in men with chemotherapy-naive castration-resistant prostate cancer at the interim analyses of the COU-AA-302 trial. Here, we present the prespecified final analysis of the trial, assessing the effect of abiraterone acetate plus prednisone on overall s

The nonionic low-osmolar contrast medium iohexol was used as marker of glomerular filtration rate (GFR) in 53 patients with stable renal function (group I: n = 32, group II: n = 21). All the patients had clearance values < or = 30 ml.min-1.1.73 m-2 body surface; 40 patients < 20 ml.min-1.1.73 m-2 body surface. Simultaneous determinations of renal clearance and plasma clearance, both as slope clear

Main recommendations: Endoscopic mucosal resection (EMR) is the standard of care for the complete removal of large (≥ 10mm) nonpedunculated colorectal polyps (LNPCPs). Increased detection of LNPCPs owing to screening colonoscopy, plus high observed rates of incomplete resection and need for surgery call for a standardized approach to training in EMR. 1 Trainees in EMR should have achieved basic co

Background: To support a victim of violence and establish the correct penalty for the perpetrator, it is crucial to correctly evaluate and communicate the severity of the violence. Recent data have shown these communications to be biased. However, computational language models provide opportunities for automated evaluation of the severity to mitigate the biases. Objective: We investigated whether

Background: Active surveillance (AS) is commonly used for men with low-risk prostate cancer (PCa). When life expectancy becomes too short for curative treatment to be beneficial, a change from AS to watchful waiting (WW) follows. Little is known about this change since it is rarely documented in medical records. Objective: To model transition from AS to WW and how this is affected by age and comor

Literature list Sustainability Science: The Field Development (MN) 1. Kates, Robert W., et al. (2001). Sustainability Science. Science 292(5517) (2 pages) 2. Clark, W. C. (Ed.). (2007). Sustainability science: A room of its own. Proceedings of the National Academy of Sciences (PNAS), 104(6), 1737-1738. (2 pages) 3. Spangenberg, J. H. (2011). Sustainability science: a review, an analysis and some e

https://www.lucsus.lu.se/sites/lucsus.lu.se/files/2024-01/PhD%20Course%20Literature%20List_25%20Jan.pdf - 2026-05-08