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Popular Abstract in Swedish Skador på skelettet kan uppstå efter bl.a. olyckor, tumörkirurgi eller strålning. Ofta är sådana skador mycket handikappande då de påverkar kroppens funktion, stabilitet och utseende. Om benvävnad saknas eller måste bytas ut använder man sig idag av mikrokirurgiska metoder, där man flyttar kroppseget ben från ett ställe till ett annat. Tyvärr innebär detta att man skapaBone deficiencies, caused by malformations, trauma or adverse effects from medical treatments, are a clinical challenge and often associated with reduced physical function and quality of life. Autologeous bone grafts can be used to reconstruct skeletal defects, but the right size and quality of bone might not always be available and even so, donor-site morbidity might follow. A pre-fabricated or t

Few studies have examined how foraging niche shift of a predator over time cascade down to local prey communities. Here we examine patterns of temporal foraging niche shifts of a generalist predator (yellow catfish, Pelteobagrus fulvidraco) and the abundance of prey communities in a subtropical lake. We predicted that the nature of these interactions would have implications for patterns in diet sh

ABSTRACT The aim of the present work was to compare patients with advanced cancer receiving specialized palliative home care with those receiving conventional care. A hospital-based advanced home care programme was initiated, in order to enable patients to remain at home for a longer period and to choose to die at home. The allocation to advanced home care (AHC) or conventional care (CC) was perf

The neuropathological substrate of dementia in patients with Parkinson's disease is still under debate, particularly in patients with insufficient alternate neuropathology for other degenerative dementias. In patients with pure Lewy body Parkinson's disease, previous post-mortem studies have shown that dopaminergic and cholinergic regulatory projection systems degenerate, but the exact pathways th

AIMS: To investigate the disease causing event in patients with familial hypercholesterolaemia, carrying two mutations each, E256K in exon 6 and I402T in exon 9, of the gene encoding the low density lipoprotein (LDL) receptor. It was not known whether the mutations were positioned in cis or trans, or if they were each pathogenic separately or only when present together. METHODS: Polymerase chain r

The quality and quantity of UV measurements have increased greatly in the last few years. Variations among measurements from different instruments are diminishing toward the 5% level. Long-term trend detection is still a problem, with little historical data available for baseline estimations. Enhanced UV levels are clearly associated with the Antarctic springtime ozone reductions. Measurements sho

Background: Non-linearities in observed log-ratios of gene expressions, also known as intensity dependent log-ratios, can often be accounted for by global biases in the two channels being compared. Any step in a microarray process may introduce such offsets and in this article we study the biases introduced by the microarray scanner and the image analysis software. Results: By scanning the same sp

Popular Abstract in Swedish Ett beräkningsprogram, "FREIA", lämpligt för industriell brandriskanalys presenteras. Programmet beräknar skada på människor inom och utom en byggnad på grund av en brand eller ett utsläpp av farligt gods. För några av de i riskanalysen ingående momenten har ytterligare forskning utförts. Dessa områden är: Detektion, Släckmedel samt Brännskada på människa. Det är i dagA tool suitable for conducting industrial fire and explosion hazard analysis is presented, together with an identification of weak links in the hazard evaluation chain. For some of the weak links additional research has been carried out. The tool, "FREIA", evaluates the consequences for humans and components due to fires and accidental releases indoors and outdoors using established engineering m

Popular Abstract in Swedish Avregleringen av elmarknaden uppmuntrar kraftbolag och oberoende kraftproducenter till att driva sina kraftverksanläggningar på ett marknadsorienterat sätt. För att behålla de ekonomiska marginalerna på plussidan så har de mest populära åtgärderna varit att förbättra elverkningsgraden genom ändringar i hårdvaran samt höja totalverkningsgraden genom till exempel samproduThe deregulation of the electricity market drives utilities and independent power producers to operate heat and power plants as profit centers. In order to keep the economic margins on the credit side, the preferred measures have been to improve the electrical efficiency through changes in the hardware and boost the overall efficiency through e.g. combined heat and power (CHP) generation. The bett

There is an increasing use of distributed computer systems to provide services in both traditional telephony as well as in the Internet. Two main technologies are Distributed Object Computing (DOC) and Web based services. One common DOC architecture investigated in this thesis is the Common Object Request Broker Architecture (CORBA), specified by the Object Management Group. CORBA applications con

AimTo reconstruct spatial and temporal patterns of European fire activity during the Holocene and to explore their potential drivers, by relating biomass burning to simulated biotic and abiotic parameters. LocationEurope. MethodsHolocene fire activity was investigated based on 156 sedimentary charcoal records from lakes and peat bogs across Europe. Charcoal data covering the last 9000 years were s

The objectives of this dissertation are 1) to describe what child protection services actually do when assessing risk and deciding on interventions, and 2) to analyze this practice in the light of institutional expectations, organizational demands and professional technology. The field work was carried out in two Danish municipal social service agencies. Data consist of records on families subject

Popular Abstract in Swedish Proteiners interaktioner med andra proteiner, med polymerer och med ytor har stor praktisk betydelse inom bland annat proteinrening, läkemedelsformulering och livsmedelsteknologi. Målet med detta arbete är att öka förståelsen för växelverkan mellan proteiner, mellan proteiner och polymerer samt mellan proteiner och ytor, särskilt beträffande de elektrostatiska krafternaInteractions of proteins with other proteins, with polymers and with surfaces are of great practical importance within for instance protein purification, drug delivery, and food technology. The aim of this work is to increase the understanding of protein-protein, protein-polyelectrolyte, and protein-surface interactions, particularly concerning the role of electrostatic interactions in these syste

Popular Abstract in Swedish Järn har den kemiska beteckningen Fe från latinskans ferrum. Det är det fjärde vanligaste ämnet i världen och utgör ca en femtedel av jordskorpan. Trots det kan både djur och växter ha järnbrist. Hur kan detta vara möjligt? Problemet är egentligen inte förekomsten av järn utan att järnet som vi och alla andra organismer behöver har oxidationstillståndet Fe(II) medan detIt is of vital importance to understand the systems for iron metabolism and this thesis contributes to this by providing insights into the structure and function of the acquisition and homeostasis of iron. The two proteins that have been primarily investigated are a ferric reductase from Arabidopsis thaliana called FRO2 and a mitochondrial iron chaperone from Saccharomyces cerevisiae called fratax

Popular Abstract in Swedish Alla celler behöver energi och de skaffar den på olika sätt, t. ex. från oxidering av mat eller från solljus. Adenosin trifosfat (ATP), som kallas för cellens energivaluta, kan dock inte syntetiseras direkt från mat eller ljus. Nästan alla organismer utnyttjar proteinkomplex i form av en andningskedja som sitter i membranet för att alstra en proton potential. Det kan liComplex I is the mitochondrial enzyme complex that oxidizes NADH produced in the citric acid cycle and reduces quinone in the membrane, coupled to proton pumping out of the mitochondrial matrix, creating a membrane potential. This process generates about 40% of the energy used by living organisms. High-resolution structures of complex I recently became available, but the molecular mechanism behind

GWAS have identified numerous SNPs associated with prostate cancer risk. One such SNP is rs10993994. It is located in the β-microseminoprotein (MSMB) promoter region, mediates MSMB prostate secretion levels, and is linked to mRNA expression changes in both MSMB and the adjacent gene NCOA4. In addition, our previous work showed a second SNP, rs7098889, is in positive linkage disequilibrium with rs1

Although predation is commonly thought to exert the strongest selective pressure on coloration in aposematic species, sexual selection may also influence coloration. Specifically, polymorphism in aposematic species cannot be explained by natural selection alone. Males of the aposematic wood tiger moth (Arctia plantaginis) are polymorphic for hindwing coloration throughout most of their range. In S

Introduction Intimate partner violence (IPV) is regarded an important public health and human rights issue, characterized by physical, sexual or emotional abuse. Globally more than one in three women report physical or sexual violence by their intimate partners. Though the association between IPV and depression is known, we found no study investigating depression as a risk factor for IPV and very

Soil and water acidification was internationally recognised as a severe environmental problem in the late 1960s. The interest in establishing “critical loads” led to a peak in weathering research in the 1980s and 1990s, since base cation weathering is the long-term counterbalance to acidification pressure. Assessments of weathering rates and associated uncertainties have recently become an area of