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Varje år sker företagsöverlåtelser för betydande värden. Företagsförvärv kan skapa stora värden, men det innebär även ett risktagande som kan leda till stora ekonomiska förluster. Ett av flera sätt som parterna kan påverka riskfördelningen mellan varandra är genom garantier. Genom att använda sig av formuleringen ”såvitt säljaren vet”, det vill säga en subjektiv garanti, kan säljaren minska det riEvery year mergers and acquisitions of significant value take place. An acquisition can create a large amount of wealth. However, it also involves taking risks, which can create big economic losses. One of many ways that the involved parties can affect the risk distribution between the parties is by using guarantees. By using the wording ”as far as the seller knows”, i.e. a subjective guarantee, t

Ca/Na montmorillonite and natural Wyoming bentonite (MX-80) have been studied experimentally and theoretically. For a clay system in equilibrium with pure water, Monte Carlo simulations predict a large swelling when the clay counterions are monovalent, while in presence of divalent counterions a limited swelling is obtained with an aqueous layer between the clay platelets of about 10 A. This latte

Flicker, or more precisely temporal light modulation (TLM), has re-emerged as a problem with the introduction of LED-based lighting technology. TLM, meaning variations in light intensity over time, may have negative effect on human health, causing annoyance, headaches, eyestrain and migraine. the negative consequences of TLM create an obstacle to broad and rapid adaptation of the new LED-technolog

Antibodies directed towards non-neutralizing epitopes on the factor VIII protein (FVIII) may be detected in patients with haemophilia A. We evaluated the prevalence of non-neutralizing antibodies, in 201 inhibitor-negative brother pairs with severe haemophilia A, enrolled in the Malmö International Brother Study and the Haemophilia Inhibitor Genetics Study. To evaluate binding specificity of the a

Purpose: To prospectively test the mathematical models for calculation of the risk of malignancy in adnexal masses that were developed on the International Ovarian Tumor Analysis (IOTA) phase 1 data set on a new data set and to compare their performance with that of pattern recognition, our standard method. Methods: Three IOTA centers included 507 new patients who all underwent a transvaginal ultr

One of the major histopathological hallmarks of Alzheimer's disease (AD) is redundant senile plaques mainly composed of beta-amyloid (Abeta) aggregates. Alternative cleavage of the amyloid precursor protein (APP), occurring in both normal and AD subjects, results in the generation and secretion of soluble APP (sAPP) and Abeta. We examined the cerebrospinal fluid (CSF) for alpha- and beta-secretase

What is normally described as bias? A possible definition comprises attempts to distort or mislead to achieve a certain perspective, i.e. subjective descriptions intended to mislead. If designers were able to exclude bias from informing systems, then this would maximize their effectiveness. This implicit conjecture appears to underpin much of the research in our field. However, in our efforts to s

The amount of large and old trees has decreased in the boreal forests during the last centuries of forestry. Such trees are important habitats for epiphytic lichens and there is a growing concern for lichen species that are associated with large and old trees. However, only little is known about the relative importance of tree size versus age as determinants of lichen diversity. Here we have deter

The deep sea is the largest habitat on earth. Its three great faunal environments - the twilight mesopelagic zone, the dark bathypelagic zone and the vast flat expanses of the benthic habitat- are home to a rich fauna of vertebrates and invertebrates. In the mesopelagic zone (150-1000 in), the down-welling daylight creates an extended scene that becomes increasingly dimmer and bluer with depth. Th

Two hypotheses concerning cerebellar function and predictive behavior are the sensory prediction hypothesis and the timing hypothesis. The former postulates that the cerebellum is critical in generating expectancies regarding forthcoming sensory information. The latter postulates that this structure is critical in generating expectancies that are precisely timed; for example, the expected duration

Popular Abstract in Swedish Avregleringen av elmarknaden uppmuntrar kraftbolag och oberoende kraftproducenter till att driva sina kraftverksanläggningar på ett marknadsorienterat sätt. För att behålla de ekonomiska marginalerna på plussidan så har de mest populära åtgärderna varit att förbättra elverkningsgraden genom ändringar i hårdvaran samt höja totalverkningsgraden genom till exempel samproduThe deregulation of the electricity market drives utilities and independent power producers to operate heat and power plants as profit centers. In order to keep the economic margins on the credit side, the preferred measures have been to improve the electrical efficiency through changes in the hardware and boost the overall efficiency through e.g. combined heat and power (CHP) generation. The bett

Background: Identification of targetable EML4-ALK fusion proteins has revolutionized the treatment of a minor subgroup of non-small cell lung cancer (NSCLC) patients. Although fluorescence in situ hybridization (FISH) is regarded as the gold standard for detection of ALK rearrangements, ALK immunohistochemistry (IHC) is often used as screening tool in clinical practice. In order to unbiasedly anal

Background and purpose — Patients having a total knee arthroplasty (TKA) after a previous high tibial osteotomy (HTO) constitute a minor group among those undergoing primary TKA for knee osteoarthritis (OA). There have been few reports on whether such patients differ pre- and postoperatively from those who undergo TKA as the first measure. We evaluated patient characteristics, knee-related pain, f

Background It has been proposed that cancer is more common in some families than in others, but the hypothesis lacks population level support. We use a novel approach by studying any cancers in large threegeneration families and thus are able to find risks even though penetrance is low. Methods Individuals in the nation-wide Swedish Family- Cancer Database were organised in three generations and t

Background and aims Little information is available on real-life occurrence of oral thrush in COPD patients treated with ICS. We investigated oral thrush incidence in COPD patients prescribed FDC ICS/LABA therapies and assessed whether it is modulated by the ICS type, dose, and delivery device. Methods We conducted a historical, observational, matched cohort study (one baseline year before and one

Pharmaceutical packaging is linked to important demographic changes. Aging ofpopulations is one of the demographic changes which has called for more attention, especially in well-developed countries. The increase in life expectancy represents a positive consequence of years of research, development of medications, and improvement in life habits. In spite of that, the growth in the number of people

Background: A key innovation may allow one group of species to radiate and replace another, but the role of competition and background extinctions for the replacement process is vigorously debated and unclear. Questions: Is a minimum competitive advantage necessary to initiate replacement? Are background extinctions of the incumbent species necessary? What speciation and extinction dynamics charac

INTRODUCTION: Clinical preventive services can detect diseases early, when they are most treatable, but these services may not be provided as recommended. Assessing the provision of services to patients at risk for cardiovascular disease (CVD) could help identify disparities and areas for improvement.METHODS: We used data on patient visits (n = 21,261) from the National Ambulatory Medical Care Sur

The αβ T-cell coreceptor CD4 enhances immune responses more than 1 million-fold in some assays, and yet the affinity of CD4 for its ligand, peptide-major histocompatibility class II (pMHC II) on antigen-presenting cells, is so weak that it was previously unquantifiable. Here, we report that a soluble form of CD4 failed to bind detectably to pMHC II in surface plasmon resonance-based assays, establ