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Gestational Islet Autoimmunity, Infections, and Type 1 Diabetes

Popular Abstract in Swedish Förekomsten av typ 1 (insulinberoende) diabetes före 15 års ålder har ökat under de senaste åren (Fig. 1) och barnen är allt yngre vid insjuknandet. Sjukdomen anses vara autoimmun, vilket innebär att kroppens eget immunförsvar angriper de insulinproducerande ?-cellerna i bukspottkörteln. En ärftlig benägenhet, som fr.a. är kopplad till s.k. vävnadsantigen på cellerna, mThe intention of this thesis was to investigate autoimmune markers for type 1 diabetes, together with signs of enterovirus infections during the pre- and perinatal period of life, and their possible association with the development of diabetes during childhood, adolescence, and young adulthood. We found that: 1. Newborns with ABO immunization, linked in epidemiological studies with heightened diab

Geriatric rehabilitation as an integral part of geriatric medicine in the Nordic countries

Objectives: First, to outline the theoretical and practical framework for geriatric rehabilitation in the Nordic countries and second, to survey the scientific medical publications for evidence-based geriatric rehabilitation. Methods: Brainstorming on geriatric rehabilitation in a working group of Nordic teachers in geriatric medicine. Papers on scientific programmes for geriatric rehabilitation f

The handling of peripheral venous catheters - from non-compliance to evidence-based needs.

Aim. To study nurses' compliance to national guidelines (Sweden) for peripheral venous catheters and to establish the complication frequency connected to time in situ and bore size. Background. Worldwide, there are no standard peripheral venous catheters guidelines, and the need for elective replacement has been challenged. Furthermore, the time interval and need for elective change of peripheral

Cholesterol-lowering and anti-atherogenic effects of oats in mice

The cholesterol-lowering effect of oats is well established, but the crucial properties eliciting this effect need to be further investigated to optimize the use of oats as functional foods. Furthermore, there are almost no reports investigating the effect of oats on atherosclerosis development. This thesis describes our work with finding suitable mouse models to study cholesterol-lowering and ant

Clearance of iohexol, 51Cr-EDTA and endogenous creatinine for determination of glomerular filtration rate in pigs with reduced renal function: a comparison between different clearance techniques

In order to simplify and/or improve determination of glomerular filtration rate (GFR) the clearances of iohexol, 51Cr-EDTA and endogenous creatinine were simultaneously determined with different techniques in 21 anesthetized landrace pigs. Their GFR had been reduced to about 1/3 or less of normal GFR. After an intravenous bolus of the GFR markers, their plasma concentration curves were followed fo

Contextual and conceptual ambiguities in supervision of artistic research : experiences from Konstnärliga forskarskolan

To accept the nomination to become the supervisor of a PhD candidate is not only to step into a specific, challenging and potentially rewarding relationship, but also to enter a new zone of uncertainty: what kind of contribution to this relationship is expected from me? In what ways is this new professional task framed and supported by the institutional context to which I belong? What do I gain fr

Anthropogenic Radionuclides in the Arctic Ocean: Distribution and Pathways

Anthropogenic radionuclide concentrations have been determined in seawater and sediment samples collected in 1991, 1994 and 1996 in the Eurasian Arctic shelf and interior. Global fallout, releases from European reprocessing plants and the Chernobyl accident are identified as the three main sources. From measurements in the Eurasian shelf seas it is concluded that the total input of Cs-134, Cs-137

Acute pancreatitis - Cellular response and dynamic inflammatory changes

Popular Abstract in Swedish Akut pankreatit (bukspottkörtelinflammation) drabbar årligen cirka 300 individer per miljon invånare i Sverige. Dödligheten ligger totalt på cirka 4-7 % och betydligt högre, cirka 20 %, vid svår nekrotiserande pankreatit. Mortaliteten är vanligen associerad med multipel organsvikt och korrelerad till storleken på det inflammatoriska svaret. Underliggande mekanismer för Acute pancreatitis (AP) is a common disorder where underlying mechanisms for the local initiating events in the pancreas, the systemic dissemination of the inflammatory response and the remote organ dysfunction still are unclear. The aim of the present study was to further characterize the dynamics and sequence of the immune response in AP, and to determine the cellular origin of the initiating ev

Bone mass in young adults - determinants and fracture prediction.

Bone mass in adolescents and young adults was studied with regard to its age-related change and its determinants. Methodological aspects of bone mass measurements and their ability to predict future fractures were investigated. Bone mineral content (BMC) and bone mineral density (BMD) were assessed by the Single Photon Absorptiometry (SPA) and Dual Energy X-ray Absorptiometry (DXA) techniques. We

Reproductive behaviour and egg development in yellowtail kingfish (Seriola lalandi Valenciennes 1833)

The spawning behaviour of wild caught brood stock as well as early egg and larval development were studied in yellowtail kingfish (Seriola lalandi). Spawning occurred naturally in the austral spring/summer (November–February) when the seawater temperature was above 17 °C. Courtship behaviour involved one male and female, and consisted of a high-speed pursuit punctuated by stalling, nipping and tou

Vision in the deep sea

The deep sea is the largest habitat on earth. Its three great faunal environments - the twilight mesopelagic zone, the dark bathypelagic zone and the vast flat expanses of the benthic habitat- are home to a rich fauna of vertebrates and invertebrates. In the mesopelagic zone (150-1000 in), the down-welling daylight creates an extended scene that becomes increasingly dimmer and bluer with depth. Th

On the Analysis and Fault-Diagnosis Tools for Small-Scale Heat and Power Plants

Popular Abstract in Swedish Avregleringen av elmarknaden uppmuntrar kraftbolag och oberoende kraftproducenter till att driva sina kraftverksanläggningar på ett marknadsorienterat sätt. För att behålla de ekonomiska marginalerna på plussidan så har de mest populära åtgärderna varit att förbättra elverkningsgraden genom ändringar i hårdvaran samt höja totalverkningsgraden genom till exempel samproduThe deregulation of the electricity market drives utilities and independent power producers to operate heat and power plants as profit centers. In order to keep the economic margins on the credit side, the preferred measures have been to improve the electrical efficiency through changes in the hardware and boost the overall efficiency through e.g. combined heat and power (CHP) generation. The bett

Validation of the Rheumatoid and Arthritis Outcome Score (RAOS) for the lower extremity

BACKGROUND: Patients with inflammatory joint diseases tend due to new treatments to be more physically active; something not taken into account by currently used outcome measures. The Rheumatoid and Arthritis Outcome Score (RAOS) is an adaptation of the Knee injury and Osteoarthritis Outcome Score (KOOS) and evaluates functional limitations of importance to physically active people with inflammato

A new direct, fast and quantitative enzyme-linked ligandsorbent assay for measurement of free protein S antigen

A new method to determine the concentration of the free protein S in plasma is described. It is an enzyme-linked ligandsorbent assay (ELSA) which utilises the protein S binding capacity of the natural ligand C4b-binding protein (C4BP) to capture the free protein S from plasma samples. The use of C4BP as ligand in the assay is possible due to the high affinity (Kd = 0.1 nM) of the interaction betwe

Hegemony and the Intellectual Function : Medialised Public Discourse on Privatisation in Sweden 1988-1993

This dissertation offers a theorisation of the ways in which the intellectual function is performed through various subject positions. In the thesis, a post-Marxist approach to discourse theory is used to address questions of discursive shifts, hegemony and the intellectual function. It is supplemented by a rhetorical political analysis in order to examine how practices and strategies involved in

Abdominal symptoms in general practice : Frequency, cancer suspicions raised, and actions taken by GPs in six European countries. Cohort study with prospective registration of cancer

Background Abdominal symptoms are diagnostically challenging to general practitioners (GPs): although common, they may indicate cancer. In a prospective cohort of patients, we examined abdominal symptom frequency, initial diagnostic suspicion, and actions of GPs in response to abdominal symptoms. Methods Over a 10-day period, 493 GPs in Norway, Denmark, Sweden, Belgium, the Netherlands, and Scotla

Composition of amino acids, fatty acids and dietary fibre monomers in kernels of Adansonia digitata and Sclerocarya birrea

There is increasing demand for sources of energy and non-meat protein with balanced amino acid profiles worldwide. Nuts are rich in protein and essential amino acids, and have a high energy value due to their high fat content. Kernels from two wild fruits in Mozambique, Adansonia digitata and Sclerocarya birrea, were selected for this study to determine their amino acid and fatty acid composition,

Landscape-scale interactions of spatial and temporal cropland heterogeneity drive biological control of cereal aphids

Agricultural landscapes are characterised by dynamic crop mosaics changing in composition and configuration over space and time. Although semi-natural habitat has been often shown to contribute to pest biological control, the effects of increasing landscape heterogeneity with cropland have been disregarded. Here, we examine how cereal aphids, their enemies and biological control are affected by th

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This thesis is an exploratory, descriptive and comparative study of teachers’ focus and teaching methods in Spanish as a third language (L3) in Sweden. The curriculum of Modern Languages emphasizes communicative competence and the purpose of the study is to examine how this is applied in the teaching of the course Spanish 4 and how the students progress during the course. Five teachers at four Sen

Traffic exposure associated with allergic asthma and allergic rhinitis in adults. A cross-sectional study in southern Sweden.

BACKGROUND: There is conflicting evidence that traffic-related air pollution is a risk factor for allergic conditions. Few studies have investigated this in adults. In adults, a high proportion of asthma, rhinitis and eczema is triggered by non-allergic factors. We investigated traffic as a risk factor for allergic versus non-allergic asthma and rhinitis, and eczema, in adults. A questionnaire fro