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Natural killer (NK) cells represent the cytotoxic member within the innate lymphoid cell (ILC) family that are important against viral infections and cancer. Although the NK cell emergence from hematopoietic stem and progenitor cells through multiple intermediate stages and the underlying regulatory gene network has been extensively studied in mice, this process is not well characterized in humans

BACKGROUND: Pancreatic adenocarcinoma located in the pancreatic body might require a portomesenteric venous resection (PVR), but data regarding surgical risks after distal pancreatectomy (DP) with PVR are sparse. Insight into additional surgical risks of DP-PVR could support preoperative counseling and intraoperative decision making. This study aimed to provide insight into the surgical outcome of

IMPORTANCE An accurate prognosis is especially pertinent in mild cognitive impairment (MCI), when individuals experience considerable uncertainty about future progression. OBJECTIVE To evaluate the prognostic value of tau positron emission tomography (PET) to predict clinical progression from MCI to dementia. DESIGN, SETTING, AND PARTICIPANTS This was a multicenter cohort study with external valid

Background: Dexmedetomidine is a selective alpha-2 agonist with minimal impact on the haemodynamic profile. It is thought to be safer than morphine or stronger opioids, which are drugs currently used for analgesia and sedation in newborn infants. Dexmedetomidine is increasingly being used in children and infants despite not being licenced for analgesia in this group. Objectives: To determine the o

Transitioning to low-input agricultural systems such as organic farming has been acknowledged as a way to mitigate negative effects of agriculture on biodiversity. However, the speed, magnitude and context dependence of biodiversity recovery after converting to organic farming remain uncertain. In this study, we explored the response of plant communities to time since transition to organic farming

Groundwater is Earth’s largest liquid freshwater resource. It is a significant component of the hydrological cycle and a buffer that sustainsrivers and freshwater-dependent ecosystems during droughts. Approximately half of the world’s population depends on groundwater fordrinking water, food, and hygiene. It is used extensively in agricultural irrigation, food production and for industrial process

Corrosion of embedded steel reinforcement is the prime influencing factor that deteriorates the structural performance and reduces the serviceability of reinforced concrete (RC) structures, especially during earthquakes. In structural elements, RC columns play a vital role in transferring the superstructure's load to the substructure. The deterioration of RC columns can affect the structures' over

Enzymes are involved in most reactions in nature. They are important both for the understanding of biological life and for reactions of industrial interest, e.g. in the production of artificial fertilizers, the production of biomass or biofuels. Enzymes with one or several metal ions are called metalloenzymes. In this thesis we study three different metalloenzymes, nitrogenase, lytic polysaccharid

The purpose of this paper is to (a) establish whether meaning recall and meaning recognition item formats test psychometrically distinct constructs of vocabulary knowledge which measure separate skills, and, if so, (b) determine whether each construct possesses unique properties predictive of L2 reading proficiency. Factor analyses and hierarchical regression were conducted on results derived from

As biological surfactants, bile salts (BSs), play important roles in biological processes, i.e., food digestion, but also in BS-related diseases, as well as in applications. In this thesis, the main focus was to gain a fundamental understanding of the intermolecular interactions between BSs and cationic block copolymers with the purpose of developing new BS sequestrants that are used in the treatm

When Jean-Francois Mayet was elected mayor of the French city of Châteauroux in 2001, he inherited a mass transit system that was functional but under-used by residents. The city, located about halfway between Paris and Bordeaux, had collective aims that were similar to other medium-sized cities in Europe: to reduce the city’s ecological footprint while improving the local economy and fostering a

Reinforcement Learning (RL) is a powerful mathematical framework that allows robots to learn complex skills by trial-and-error. Despite numerous successes in many applications, RL algorithms still require thousands of trials to converge to high-performing policies, can produce dangerous behaviors while learning, and the optimized policies (usually modeled as neural networks) give almost zero expla

Objectives The aim was to study the development of radiographic knee osteoarthritis (RKOA) in individuals with knee pain over 2 years, and the associations between radiographic changes and baseline variables. Design Longitudinal cohort study. Participants and setting This study is part of the Halland Osteoarthritis cohort. The included 178 individuals, aged 30-67, had knee pain, without cruciate l

Innovation and its management in retail organisations is an emerging field, yet the measurement of innovation in this context remains challenging and under-researched. The study investigates innovation in large Swedish retail companies, focusing on monitoring and measurement of innovation performance. Through a qualitative, multiple case study, our findings reveal that retailers are aiming to beco

The idea of facilitating labour mobility for refugees as a pathway for admission is back on the policy agenda. Such complementary pathways are promoted in the Global Compact for Refugees as means to facilitate access to protection and solutions in addition to resettlement, and praised by United Nations High Commissioner for Refugees as directly contributing to easing pressure on host countries by

This study has been carried out as an assignment in the 2021 Readership Course (GB_S91) at LTH. The motivation for this study was to obtain a further understanding of the situation of PhD students and supervisors who operate in an interdisciplinary research context. The focus is on finding the positive aspects, as well as existing challenges, to comprehend how to provide future PhD students with a

Transmissibility has increased during the evolution of SARS-CoV-2, possibly by improved airborne transmission. An increased transmission was noted also in many hospitals. We analyzed SARS-CoV-2 in room air of hospitalized Omicron infected patients and compared results with previous findings with pre-Delta variants to study if SARS-CoV-2 was more prevalent in patient rooms after the introduction of

PurposeLeucine rich alpha-2 glycoprotein 1 (LRG1) has emerged as a promising biomarker for appendicitis, especially in pediatric patients. However, the currently available data are sparse, and the biomarker must be validated in more settings and compared to standard inflammatory markers. We aimed to evaluate the diagnostic and discriminative utility of serum and urine LRG1 in children with other c

Universities are expected to play a proactive role in the sustainable development andtransformation of their regions. However, they face external and internal barriers toplay that role. One possible approach to overcome those barriers is through trans-formative academic institutions (TAIs). TAIs are defined as research centres createdwithin universities to proactively engage in territorial develop