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pH dependency of ligand binding to cellobiohydrolase 1 (Cel7A) - Affinity, selectivity and inhibition for designed propranolol analogues

The affinity and enantioselectivity have been determined for designed propranolol derivatives as ligands for Cel7A by capillary electrophoresis (CE) at pH 7.0. These results have been compared to measurements at pH 5.0. In agreement with previous studies, the affinity increased at the higher pH. However, the affinity was not as dependent of the ligand structure at pH 7.0 as at pH 5.0, and the sele

"Dödshugget mot vår nationella tonkonst". Hæffnertidens koralreform i historisk, etnohymnologisk och musikteologisk belysning.

Popular Abstract in Swedish I denna bok undersöks det begynnande 1800-talets svenska reform av kyrkosången. I fokus står J C F Hæffners koralbok 1820, med dess privat utgivna andra del 1821, som här för första gången ägnas en ingående idéhistorisk analys. Hæffners utgåva har kritiserats hårt för att ha tagit död på den s.k. folkliga koralsången — ”dödshugget mot vår nationella tonkonst” — och istäThis thesis analyses the Swedish chorale book in two parts edited by J.C.F. Hæffner in 1820-21 to the new hymnal by Wallin of 1819. This is done in relation to the ideas and practices of the time; earlier and up to present times this chorale style has been described as a “petrified” hymnody, with a rhythmic equalisation, slow tempo, melodic trivialization and harmonic uniformity. To understand th

In-between strengthened accessibility and economic demands : analysing self-service libraries from a user perspective

Purpose - The aim of this paper is to explore the implementation of self-service at public libraries from the perspective of their users. The implementation of self-service is related to a diverse societal context including for example an overall digitalisation, budget constraints and political expectations on public libraries to contribute to marketing the local community.Methodology - Semi-struc

Lateralized frontal blood flow increases during fluency tasks : influence of cognitive strategy

Difficulties with verbal fluency tasks (VFIT) have been shown mainly to be associated with left frontal lobe pathology in lesion studies. The design fluency test (DFT) is a non-verbal analogue of word fluency tasks and has, in patients with right frontal lobe pathology, been coupled to an inability to perform well. Regional cerebral blood flow measurements (rCBF) were made in normals to elucidate

MNE microfoundations and routines for building a legitimate and sustainable position in emerging markets

A number of studies have analysed how multinational enterprises (MNEs) develop appropriate strategies for managing the institutionally different contexts of various markets. However, we still know rather little about how MNEs manage different institutional pressures when they operate in emerging markets. These markets have a higher level of uncertainty as their values and structures undergo change

Nerve regeneration across an extended gap : a neurobiological view of nerve repair and the possible involvement of neuronotrophic factors

We have compared the anatomic and functional regeneration of a transected sciatic nerve following regrowth from its proximal stump through either preformed empty mesothelial chambers or autologous nerve grafts bridging a 10 mm gap. Within the mesothelial chambers an organized multifascicular nerve trunk forms between the proximal and distal stumps. After 3 months, distal segment cross sections fro

Disclosure and police reporting of intimate partner violence postpartum : a pilot study

Objective: intimate partner violence is a significant health problem. Fear of retaliation and shame may prevent women from telling anyone about the violence. This study investigated the prevalence of disclosure and police reporting of intimate partner violence during the first year postpartum. Design: a prospective longitudinal Swedish cohort study based on information from 2563 women who answered

Adoption of alternative fuel vehicles : Influence from neighbors, family and coworkers

During the last years, many governments have set targets for increasing the share of biofuels in the transportation sector. Understanding consumer behavior is essential in designing policies that efficiently increase the uptake of cleaner technologies. In this paper we analyze adopters and non-adopters of alternative fuel vehicles (AFVs). We use diffusion of innovation theory and the established n

A Cholesky decomposition based massive MIMO uplink detector with adaptive interpolation

An adaptive uplink detection scheme for a Massive MIMO (MaMi) base station serving up to 16 users is presented. Considering user distribution in a cell, selective matched filtering (MF) is proposed for non-interference limited users and a Cholesky decomposition (CD) based zero-forcing (ZF) detector is implemented for the remaining users. Channel conditions such as coherence bandwidth are exploited

Self-reported mindfulness mediates the relation between meditation experience and psychological well-being

A well established notion in Buddhist literature is that meditation practice improves the ability to be mindful in daily life which in turn promotes psychological wellbeing. In order to test this hypothesis the relations between meditation experience, five mindfulness facets and psychological well-being were studied in a sample consisting of Buddhist meditators, Western mindfulness meditators and

Infant Health and Longevity: Evidence from A Historical Intervention in Sweden

This paper investigates the potential of an infant intervention to improve life expectancy, contributing to emerging interest in the early life origins of chronic disease. We track individuals from birth to death, and are able to identify age and cause of death. The intervention was pioneered in Sweden in 1931–1933, and appears to have been pivotal in the emergence of universal infant care program

Kan vi lukta oss till ett bättre minne?

Ett växande antal studier rapporterar ett samband mellan minne och lukter. Den här studien ämnade identifiera effekter av samma och olika lukter vid inlärning och återkallande av minne samt undersöka skillnaden mellan goda och inte goda lukter. En så kallad old / new recognition task användes som minnestest där deltagarna (N = 32) tränade in 20 ord i testets första fas, för att sedan i en andra faA growing number of studies report relations between memory and smell. The present study aimed to identify differential effects of same and different smells on word learning and recognition memory, in addition to investigate the difference between pleasant and unpleasant smells. An old / new recognition task was used as a memory test, whereby participants (N = 32) studied 20 words in the first pha

Rehabkoordinatorn: Chefers erfarenheter av och uppfattningar om en ny funktion i vården

Studiens syfte var att studera chefers uppfattningar och erfarenheter av funktionen rehabkoordinator och nyttan av den utbildning som rehabkoordinatorn har genomgått. Semistrukturerade intervjuer utfördes med tio chefer inom sjukvården. Datamaterialet analyserades med tematisk analys utifrån en induktiv ansats. Fyra teman urskildes: Räddaren i nöden, Funktionen som blev en person, Förändring tar tThe aim of the study was to investigate how health care service managers perceive and experience the newly introduced function rehabilitation coordinator and the effect of the education programme. A semi-structured interview guide was used to interview ten managers. The material was analysed with an inductive approach using thematic analysis. The following four themes were identified during analys

The influence of organizational culture on problem creation process: exploring the relationship using CAS perspective

Research question: How does organizational culture, using complex adaptive systems perspective, influence problem creation process in the front end of innovation? Theoretical perspectives: Front end of innovation literature is the core subject of this thesis,focusing on problem creation process. Academic literature on organizational culture and complex adaptive systems is presented to show the re

Voluntary Sector Organisation Public Partnerships (IOPs) - enabling or undermining the democratic voice of voluntary organisations?

Voluntary Sector Organisation Public Partnerships (IOP) are a new collaboration form for voluntary and public organisations aiming to give financial support to a welfare service provided by the voluntary actor. The aim of this study is to examine to what extent a voluntary organisation can be independent in order to be able to advocate as an IOP-participant. The object of study is the Red Cross an

En självständig del av samhället : En kvalitativ studie om föräldrarnas beskrivning av deras psykiskt funktionsnedsatta unga vuxna barns självständighet och delaktighet i samhället.

The essay's overall purpose was to study the parents 'interpretation of their young adults' independence and participation in society. The study has been performed on a qualitative approach in the form of unstructured interview in the form of a focus group with five parents of young adults aged 21-22 years with a mental disability. The data consists of a sound recording. The empirical

En studie på samband mellan jordmekaniska egenskaper och hydrodynamiska processer när erosion påverkar släntstabiliteten vid ökad nederbörd

Älvar och vattendrag i Västra Sverige utsätts för konstant erosion när ytvattnet från sjöar och mark tappas ut i havet. Den geologiska sammansättningen i älvarna under högsta kustlinjen består av glaciala och postglaciala finkorniga sediment som är avsatta i marin miljö. De känsliga lerlagrens struktur har efter urlakning blivit mer instabila och vid störning kan utlösa skred. Effekten av klimatföRivers and streams in Western Sweden are exposed to constant erosion when surface water from lakes and land discharge into the sea. The geological composition of the rivers under the highest coastline consists of glacial and postglacial fine-grained sediments deposited in marine environments. The leakage of the sensitive clay layers has become more unstable after leaching and, in the event of a di

Sänkta förväntningar- vägen till lycka? - En kvantitativ studie av sambandet mellan förväntningar, subjektivt välbefinnande och Locus of Control.

Den här studien syftar till att undersöka sambandet mellan faktorerna Locus of Control (LOC), förväntningar på framtiden och subjektivt välbefinnande. Tidigare forskning har visat på att intern LOC korrelerar med högt välbefinnande och extern LOC korrelerar med lågt välbefinnande. När det kommer till att säga vilka slags förväntningar, det vill säga höga eller låga, som en person mår bäst av att hThe purpose of this study is to examine the relationship between the variables Locus of Control (LOC), expectations on the future and subjective well being (SWB). Previous research suggest that internal LOC correlates with high SWB and that external LOC correlates with low SWB. When it comes to the determining if high or low expectations are most profitable for ones SWB, previous research is divid

The Curse of Corruption - A quantitative analysis of the association between Administrative Capacity and Violence

It is not uncommon that states repress and oppress its citizens by exerting violence upon them. Sometimes this violence leads to cases where states abuse their power. This abuse can lead to terrible consequences which several historical and contemporary cases shows. When analyzing state violence, it ought to be put in the context of violence from non-state actors, which often eclipse the violence