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Ki67 proliferation in core biopsies versus surgical samples - a model for neo-adjuvant breast cancer studies

Background: An increasing number of neo-adjuvant breast cancer studies are being conducted and a novel model for tumor biological studies, the "window-of-opportunity" model, has revealed several advantages. Change in tumor cell proliferation, estimated by Ki67-expression in pre-therapeutic core biopsies versus post-therapeutic surgical samples is often the primary end-point. The aim of the present

Hoplitarmén och dess utveckling

This paper is about the hoplite army and the men in it who fought for their family and polis. I wanted to write this paper because I think that we get too little information about the ordinary men who fight in wars. We are always told about the great generals and the outcomes of the battles but never about those who have to leave their normal life to maybe get killed. My purpose is to give a broad

The narrative assessment of attachment: validity of the Secure Base Script Test for middle childhood

Psouni and Apetroaia (2010) have recently introduced the Secure Base Script Test,SBST, for middle childhood. Based on Waters and Rodrigues-Doolabh’s (2004)Narrative Script Assessment for assessing secure base script knowledge in adults,Psouni and Apetroaia’s method is a narrative task in which children create short narratives by making use of four prompt word outlines that loosely suggest prototyp

Familjehem och sammanbrott - Möjligheter och begränsningar vid familjehemsplacering av barn och unga

The purpose of this paper was to examine and analyse which possibilities and limits that exist when putting children in to foster homes. Through interviews with ten social workers, our aim was to answer the following questions: - Which factors will increase the possibility of breakdowns? - Which factors will reduce the possibility of breakdowns? - How does the social service work to prevent break

Through the Eyes of the Child A Study of Children's Experiences at the Time Their Parents Separate:What Happens in These Children's Lives Seen from Their Own Point of View

The main purpose of this study is to form a picture of what happens in a child's life when their parents separate and how this event is seen through the child's eyes. This study is based on qualitative research methods in which eleven children from six families were interviewed. In addition, the parents were asked a few questions about their custody arrangements and the amount of the coop

Furniture Design beyond Usability. Changes for People in the Third Age when Moving to a New Home.

User-centred design approaches within the field of furniture design for old people involves an act of embracing and balancing various end-user needs and assessing their relative importance for the product experience. It is often assumed that older people’s physiological needs dominate their other needs. In the present study, three focus group interviews were carried out with the exploratory purpos

Experience of meaning in everyday occupations among unemployed people with severe mental illness.

Abstract The aim of this qualitative study was to examine the different facets of meaning that people who are severely mentally ill and unemployed may find in their everyday occupations. Twelve unemployed people with severe mental illness, six who attended day centres and six who did not, were interviewed regarding their experience of meaning in everyday occupations. The data were analysed with co

Facilitating collaboration: exploring a socio-technical approach to the design of a collaboratory for Library and Information Science

The thesis explores the potential of one way of facilitating and stimulating collaboration in Library and Information Science (LIS), through a specific scientific collaboration activity: creating, sharing and reusing data collection instruments, such as interview guides, questionnaires, and observation protocols. The four studies reported in the thesis can be read as a linear narrative, each study

Improved Interpretation of Myocardial Perfusion Images by Artificial Neural Networks

Popular Abstract in Swedish Tolkning av medicinska bilder kan vara svår och påverkar i hög grad det fortsatta handläggandet av patienten. De viktigaste förutsättningarna för ett bra tolkningsresultat är förutom läkarens erfarenhet, som byggs upp genom att tolka många bilder, även kvaliteten på bilderna. Under det senaste decenniet har bilddiagnostiken utvecklats snabbt. Digitaliseringen av bilden Correct interpretation of medical imaging is based upon the interpreter’s experience and image quality. Depending on the report given the clinician decides how to use the result of the study. For many years a large number of image technologies including myocardial perfusion scintigraphy (MPS) have been acquired in digital format and the development of the imaging modalities are progressing rapidly

Coulomb excitation of Ga-73

The B(E2; I-i -> I-f) values for transitions in Ga-71(31)40 and Ga-73(31)42 were deduced from a Coulomb excitation experiment at the safe energy of 2.95 MeV/nucleon using post-accelerated beams of Ga-71,Ga-73 at the REX-ISOLDE on-line isotope mass separator facility. The emitted gamma rays were detected by the MINIBALL gamma-detector array, and B(E2; I-i -> I-f) values were obtained from the yield

Andean Speciation and Vicariance in Neotropical Macrocarpaea (Gentianaceae-Helieae)

The pains Macrocarpaea (Griseb.) Gilg (Gentianaceae. Helieae) is among the largest woody genera of tropical gentians, with most of its species occurring in the wet mountainous forest., of the Andes. Phylogenetic and dispersal-vicariance analyses (DIVA) of 57 of the 105 currently recognized species in the genus. Using two data sets front nuclear DNA (ITS and 5S-NTS sequences) and morphology. show i

Meta-analysis of genome-wide studies identifies WNT16 and ESR1 SNPs associated with bone mineral density in premenopausal women

Previous genome-wide association studies (GWAS) have identified common variants in genes associated with variation in bone mineral density (BMD), although most have been carried out in combined samples of older women and men. Meta-analyses of these results have identified numerous single-nucleotide polymorphisms (SNPs) of modest effect at genome-wide significance levels in genes involved in both b

Visual navigation in starfish: first evidence for the use of vision and eyes in starfish.

Most known starfish species possess a compound eye at the tip of each arm, which, except for the lack of true optics, resembles an arthropod compound eye. Although these compound eyes have been known for about two centuries, no visually guided behaviour has ever been directly associated with their presence. There are indications that they are involved in negative phototaxis but this may also be go

Effect of light intensity on flight control and temporal properties of photoreceptors in bumblebees.

To control flight, insects rely on the pattern of visual motion generated on the retina as they move through the environment. When light levels fall, vision becomes less reliable and flight control thus becomes more challenging. Here, we investigated the effect of light intensity on flight control by filming the trajectories of free-flying bumblebees (Bombus terrestris, Linnaeus, 1758) in an exper

A general model of resonance capture in planetary systems: first- and second-order resonances

Mean motion resonances are a common feature of both our own Solar system and of extrasolar planetary systems. Bodies can be trapped in resonance when their orbital semimajor axes change, for instance when they migrate through a protoplanetary disc. We use a Hamiltonian model to thoroughly investigate the capture behaviour for first- and second-order resonances. Using this method, all resonances of

Judicial Independence: A Legal Research on Its Theoretical Aspects, Practices from Germany, The United States of America, France, Vietnam, and Recommendations for Vietnam

It is widely recognized that judicial independence is an indispensable value of a modern democracy. When a country wishes to adopt this value, questions may arise, such as what it is and how to develop it properly? This thesis explores the issue of judicial independence in two aspects: theoretical and practical. For the theoretical aspect, it first examines the rule of law and protection of human

Time-triggered garbage collection - Robust and adaptive real-time GC scheduling for embedded systems

The advent of Java and similar languages on the real-time system scene necessitates the development of efficient strategies for scheduling the work of a garbage collector in a non-intrusive way. We propose a scheduling strategy, time-triggered garbage collection, based on assigning the collector a deadline for when it must complete its current cycle. We show that a time-triggered CC with fixed dea

Lawyers in Venture Capital Contracting: Theory and Evidence

Real-world financial contracts are sometimes so complex that it can be difficult to understand their exact payoff consequences. We develop and test a theoretical model of a venture capitalist (VC) negotiating with an entrepreneur who may overweigh or underweigh the payoff consequences of contractual downside protection (DP). A lawyer with expertise in venture capital can inform the entrepreneur ab

Development and evaluation of the aerosol dynamics and gas phase chemistry model ADCHEM

The aim of this work was to develop a model suited for detailed studies of aerosol dynamics, gas and particle phase chemistry within urban plumes, from local scale (1x1 km(2)) to regional scale. This article describes and evaluates the trajectory model for Aerosol Dynamics, gas and particle phase CHEMistry and radiative transfer (AD-CHEM). The model treats both vertical and horizontal dispersion p