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Saccharomyces cerevisiae produces ethanol efficiently from the hexose sugars in lignocellulose hydrolysates, but it can not utilise pentose sugars such as xylose and arabinose. Stable xylose-utilising S. cerevisiae strains obtained by integration of the Pichia stipitis genes encoding xylose reductase (XR), xylitol dehydrogenase (XDH) and xylulokinase, exhibit low ethanol yields when utilising xylo

Paper A investigates how to simulate a differentiated mean in cases where interchanging differentiation and expectation is not allowed. Three approaches are available, finite differences (FD's), infinitesimal perturbation analysis (IPA) and the likelihood ratio score function (LRSF) method. We study FD's under discontinuities and show that the optimal decay rate of the mean square error is typical

In the lower siliceous uplands of Central Europe, various types of nutrient-poor grasslands are widespread and grow intermingled. These species-rich grasslands, often dominated by taxa of the Festuca ovina aggregate, comprise various phytosociological classes. They are remnants of a historic rural landscape and are of conservation importance. Few studies on such grasslands are available and there

We have studied how low pH affects the water-oxidizing complex in Photosystem II when depleted of the essential Ca2+ ion cofactor. For these samples, it was found that the EPR signal from the YZ radical decays faster at low pH than at high pH. At 20 C, YZ decays with biphasic kinetics. At pH 6.5, the fast phase encompasses about 65% of the amplitude and has a lifetime of ~0.8 s, while the slow pha

Objective To describe the views of people, 65 years and over, receiving continuous public care and service, on prioritization and resource allocation in health care, in relation to gender, age, housing, health-related quality of life (QoL) and degree of activities of daily living (ADL) dependency. Background How older people receiving continuous public care and service view prioritization and res

As a consequence of heightened concern for the greenhouse effect, depleting oil reserves and skyrocketing oil prices, renewable fuels, Such as bioethanol, are becoming increasingly important. Cellulosic biomass like wood, agricultural residue and herbaceous material is a huge, cheap natural resource that can be used for ethanol production. Decreasing production costs through technological developm

An improved Volume of Fluid (VOF) method is presented which is applicable to high density ratio 3D flows for a large range of bubble Reynolds number (Re). The method is based on the Navier-Stokes equations for incompressible multi-phase flows which are discretized on a Cartesian staggered grid. The multi-grid technique together with the pressure-velocity coupling scheme for multi-phase flows have

The influence of the auxotrophic deficiencies of the host strain and expression vector selection on the production of a heterologous protein was investigated. Heterologous xylanase production by two prototrophic S. cerevisiae transformants, containing either a plasmid-based, YEp-type expression system or an integrative, YIp-type expression system, were compared with production by an auxotrophic tr

The accuracy and precision of frameless neuronavigation as compared to conventional frame-based stereotaxy for implantation of deep brain stimulation (DBS) electrodes were studied in 14 patients with essential tremor. DBS electrodes were implanted bilaterally in the ventrolateral thalamus [ventrointermediate nucleus ( VIM)] in one procedure. Frameless neuronavigation was used on one side and the c

Popular Abstract in Swedish Vid framställning av koncentrerade fruktjuicer utsätts produkten för värmebehandling i form av indunstning och pastörisering. Värme-behandlingen försämrar produktens sensoriska kvalitet, dels eftersom aromerna är flyktiga och snabbt avdunstar, och dels eftersom värmen påskyndar kemiska förändringar av aromämnena. Några viktiga fördelar uppnås dock genom tillverkning av During production of concentrated fruit juices, both physical and chemical losses of aroma compounds occur due to heat treatment such as pasteurisation and evaporation. This leads to an inferior quality of the final product. By recovering the aroma complex from fresh juice and then adding it back to the processed juice, heat treatment can be avoided. Hydrophobic pervaporation is an emerging membr

Today, Brahe Church mainly exhibits signs of the period of greatness of Visingsö island during the seventeenth century. However, there are also traces from much earlier periods. Ströja Church was built during the twelfth century, when the House of Erik and the House of Sverker contested for the title of king and the island of Visingsö had a prominent position in the new country of Sweden. We do no

Regular weight-bearing exercise, especially during the pre- or early peripubertal years, leads to substantial benefits in bone mass and skeletal structure, enhancing bone strength at loaded sites. However, few fragility fractures occur in young adulthood, and only if the exercise-induced skeletal benefits are retained into older age, a time when the incidence of fragility fractures rises exponenti

The worldwide growing demand for whey proteins and derivatives requires more efficient and sustainable whey protein production processes. Whey is an important by-product from cheese manufacturing. In whey industry membrane processes such as microfiltration, ultrafiltration, nanofiltration and reverse osmosis are well-established to concentrate, fractionate and purify whey proteins as well as whey

The derivation of dopamine neurons from human embryonic stem cells (hESCs) now offers a promising alternative to fetal tissue for cell replacement therapy (CRT) in Parkinson´s disease (PD). Using the appropriate chemical cues in vitro, hESCs can be patterned towards bona-fide ventral midbrain (VM) DA neurons that survive, reinnervate, release DA and provide functional recovery when transplanted in

Non-technical summary Agriculture provides many benefits to people, such as producing food and creating jobs in rural areas, but it can also have negative impacts on the environment. We analysed existing monitoring indicators for the European Union’s Common Agricultural Policy (CAP) to evaluate whether the CAP is effectively achieving multiple social and environmental goals. We found that the curr

Health applications have increasingly been used to improve physical, mental and social well-being. Chronic pain (CP) is defined as pain that lasts for a period of three months and causes sporadic or constant discomfort. In Portugal, the treatments for this type of pain are almost exclusively pharmacological and with known limited effects. Endowing patients with self-management skills, will help th

Much of the income equalization that took place during the first half of the twentieth century was driven by shifts in the shares of the incomes of the rich, such as the top 1 percent. But the available studies using tabulated data have not been wholly able to account for the relative decline in top earners’ incomes. In this paper, we present the first evidence on the composition of the top groups

The over-arching aim of the access and benefit-sharing (ABS) of genetic resources is to enable fair distribution of benefits between the users (such as universities and biotech companies) and providers (such as biodiversity rich countries) so as to both open the doors for innovation and create incentives for biodiversity conservation. Access to genetic resources is crucial for research related to

Objective: Accumulation of amyloid-β is among the earliest changes in Alzheimer’s disease (AD). Amyloid-β positron emission tomography (PET) and Aβ42 in cerebrospinal fluid (CSF) both assess amyloid-β pathology in-vivo, but 10–20% of cases show discordant (CSF+/PET− or CSF-/PET+) results. The neuropathological correspondence with amyloid-β CSF/PET discordance is unknown. Methods: We included 21 pa

A negative association between insulin‐dependent diabetes mellitus (IDDM) and HLA‐DR, DQA1 or DQB1 was found in a large population‐based investigation of childhood‐onset patients (more than 420 patients) and controls (more than 340 controls) from Sweden. The relative risk was decreased for several haplotypes that were negatively associated with IDDM: DR15‐DQA1*0102‐DQB1*0602, DR7‐DQA1*0201‐DQB1*03