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Carbon Fiber Composite Materials in Modern Day Automotive Production Lines – A Case Study

New and innovative production equipment can be developed by introducing lightweight materials in modern day automotive industry production lines. The properties of these new materials are expected to result in improved ergonomics, energy savings, increased flexibility and more robust equipment, which in the end will result in enhanced productivity. Carbon composite materials are one such alternati

Pregnancy outcomes in multiple sclerosis following subcutaneous interferon beta-1a Therapy.

Background: Women with multiple sclerosis (MS) are advised to discontinue interferon-beta therapy before trying to conceive. Unplanned pregnancies occur and risks related to exposure remain unclear. Methods: To determine pregnancy outcomes following interferon-beta therapy, we examined pregnancies from a global drug safety database containing individual case safety reports received in the post-mar

Methods, quality control and specimen management in an international multicentre investigation of type 1 diabetes: TEDDY

BackgroundThe vast array and quantity of longitudinal samples collected in The Environmental Determinants of Diabetes in the Young study present a series of challenges in terms of quality control procedures and data validity. To address this, pilot studies have been conducted to standardize and enhance both biospecimen collection and sample obtainment in terms of autoantibody collection, stool sam

High-order surface tension VOF-model for 3D bubble flows with high density ratio

An improved Volume of Fluid (VOF) method is presented which is applicable to high density ratio 3D flows for a large range of bubble Reynolds number (Re). The method is based on the Navier-Stokes equations for incompressible multi-phase flows which are discretized on a Cartesian staggered grid. The multi-grid technique together with the pressure-velocity coupling scheme for multi-phase flows have

Evaluation of oxalate/oxalic acid for extracting plant available phosphorus in unfertilized acid soils

The extractability of phosphorus (P) was studied in an acid, unfertilized soil at an abandoned farm and in 40 different soils from former agricultural fields and pastures. Oxalate/Oxalic acid extraction was compared with a number of other methods in order to evaluate the suitability of oxalate/oxalic acid as a method for extracting P from soil. The extracting efficiency and a rough estimate of the

Methodological study of affine transformations of gene expression data with proposed robust non-parametric multi-dimensional normalization method

Background: Low-level processing and normalization of microarray data are most important steps in microarray analysis, which have profound impact on downstream analysis. Multiple methods have been suggested to date, but it is not clear which is the best. It is therefore important to further study the different normalization methods in detail and the nature of microarray data in general. Results: A

Association between gross motor function (GMFCS) and manual ability (MACS) in children with cerebral palsy. A population-based study of 359 children

Background: The Gross Motor Function Classification System (GMFCS) has become an important tool to describe motor function in children with Cerebral Palsy (CP). The Manual Ability Classification System (MACS) was developed recently as a corresponding classification of manual ability. The aim of this study was to describe the association between gross motor function and manual ability in a total po

Value of exercise data for the interpretation of myocardial perfusion SPECT

Background. Artificial neural networks have successfully been applied for automated interpretation of myocardial perfusion images. So far the networks have used data from the myocardial perfusion images only. The purpose of this study was to investigate whether the automated interpretation of myocardial perfusion images with the use of artificial neural networks was improved if clinical data were

Topics in Simulation and Stochastic Analysis

Paper A investigates how to simulate a differentiated mean in cases where interchanging differentiation and expectation is not allowed. Three approaches are available, finite differences (FD's), infinitesimal perturbation analysis (IPA) and the likelihood ratio score function (LRSF) method. We study FD's under discontinuities and show that the optimal decay rate of the mean square error is typical

Making Radical Cations Live Longer

The acid-catalyzed rearrangement of 1,4,5,8-tetramethylnaphthalene was used to determine the acidity of media used for EPR spectral studies of radical cations. The radical cations of methyl-substituted naphthalenes were shown to undergo dimerization reactions. The apparent persistency of the radical cation of hexamethylbenzene was due to the slow oxidation when thallium(III) trifluoroacetate was

Controlling the Influent Load to Wastewater Treatment Plants

The need for control of the influent load to a wastewater treatment plant (WWTP) is becoming more important. One reason for this is that there are a number of things that cannot be achieved with plant-focused control. For instance it is hard to avoid sludge loss as a result of poor settling or reducing a too high influent flow rate by in-plant control actions. It is also difficult to reduce the ef

Misdiagnosis of Rheumatoid Arthritis in a Long-Term Cohort of Early Arthritis Based on the ACR-1987 Classification Criteria

Objective: Correct diagnosis of early rheumatoid arthritis (RA) is essential for optimal treatment choices. No pathognomonic test is available, and diagnosis is based on classification criteria, which can result in misdiagnosis. Here, we examined the differences between actual and misdiagnosed RA cases in a long-term cohort of patients included based on the ACR-1987 classification criteria. Method

COVID-19-related hospital admission in spouses of partners in at-risk occupations

OBJECTIVE: This study aimed to quantify the risk of COVID-19-related hospital admission in spouses living with partners in at-risk occupations in Denmark during 2020-21.METHODS: Within a registry-based cohort of all Danish employees (N=2 451 542), we identified cohabiting couples, in which at least one member (spouse) held a job that according to a job exposure matrix entailed low risk of occupati

The K2-OjOS Project : New and revisited planets and candidates in K2 campaigns 5, 16, & 18

We present the first results of K2-OjOS, a collaborative project between professional and amateur astronomers primarily aimed to detect, characterize, and validate new extrasolar planets. For this work, 10 amateur astronomers looked for planetary signals by visually inspecting the 20 427 light curves of K2 campaign 18 (C18). They found 42 planet candidates, of which 18 are new detections and 24 ha

Design and Usability of an E-Health Mobile Application

Health applications have increasingly been used to improve physical, mental and social well-being. Chronic pain (CP) is defined as pain that lasts for a period of three months and causes sporadic or constant discomfort. In Portugal, the treatments for this type of pain are almost exclusively pharmacological and with known limited effects. Endowing patients with self-management skills, will help th

What Happened to the Incomes of the Rich during the Great Levelling? Evidence from Swedish Individual-level Data, 1909–1950

Much of the income equalization that took place during the first half of the twentieth century was driven by shifts in the shares of the incomes of the rich, such as the top 1 percent. But the available studies using tabulated data have not been wholly able to account for the relative decline in top earners’ incomes. In this paper, we present the first evidence on the composition of the top groups

Balanced options for access and benefit-sharing : stakeholder insights on provider country legislation

The over-arching aim of the access and benefit-sharing (ABS) of genetic resources is to enable fair distribution of benefits between the users (such as universities and biotech companies) and providers (such as biodiversity rich countries) so as to both open the doors for innovation and create incentives for biodiversity conservation. Access to genetic resources is crucial for research related to

A simple screening assay for the most common JK*0 alleles revealed compound heterozygosity in Jk(a-b-) probands from Guam

The Jk(a-b-) phenotype results from alterations in the JK gene and is characterized by absence of the RBC urea transporter in the cell membrane. The frequency of Jk(a-b-) varies among populations, but this phenotype is most commonly found in people of Polynesian and Finnish descent. Although rare, Jk(a-b-) individuals present a clinical challenge because anti-Jk3 is produced readily in response to

Strengthening antimicrobial resistance diagnostic capacity in rural rwanda : A feasibility assessment

Introduction: Antimicrobial resistance (AMR) is a global public health threat. Worse still, there is a paucity of data from low-and middle-income countries to inform rational antibiotic use. Objective: Assess the feasibility of setting up microbiology capacity for AMR testing and estimate the cost of setting up microbiology testing capacity at rural district hospitals in Rwanda. Methods: Laborator