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Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory joint disease that affects all aspects of life. Rheumatology care strives to achieve optimal health based on person-centred care (PCC). Effective treatment is available, but patients still experience unmet needs.Aims: The overall aim of this thesis was to explore patients' perspectives of PCC and preferred outcomes in early RA. Specifi

Environmental changes such as extreme weather events become increasingly noticeable worldwide. Earth observation data provide information about such changes, but little is known about citizens’ perceptions of and responses to such changes. Across three studies, we assess whether people’s place attachment on different regional levels predicts interest in earth observation data, and whether perceive

With a national prevalence of 4.9% in the adult population, the HIV-1 epidemic in Kenya is the fifth largest in the world. HIV-1 prevalence is more than three-fold higher among HIV key populations – including men who have sex with men (MSM), people who inject drugs (PWID), and female sex workers (FSW) than in the general heterosexual (HET) population. However, the contribution of different risk gr

When applying membrane processes on industrial scale in the food industry both the fouling and the subsequent cleaning of the membranes are key but often underestimated factors. This presentation will focus on the impact of pre-treatment, operation conditions and module design on fouling and cleaning.After reviewing the current state-of-the-art of membrane fouling and cleaning in the food industry

Popular Abstract in Swedish Denna avhandling hade som målsättning att belysa långtidsförloppet vid primärt Sjögrens syndrom (SS). Studierna är baserade på registret över SS-patienter vid Universitetssjukhuset MAS och de Amerikansk-Europeiska konsensuskriterierna för SS från 2002. Helicobacter pylori (H. pylori) är inte mer prevalent bland SS-patienter än bland kontrollpersoner. Bakteriens förekomThis work was aimed at improving our understanding of the course of primary Sjögren's syndrome (SS). The Malmö SS patient register and the 2002 American-European Consensus Criteria formed the basis of all studies. Helicobacter pylori (H. pylori) was not more prevalent in SS patients or associated with severe glandular or immunological dysfunction. Consequently, our results do not support screenin

Abstract in UndeterminedHistorically, the function of Arctic ecosystems in terms of cycles of nutrients and carbon has led to low levels of primary production and exchanges of energy, water and greenhouse gases have led to low local and regional cooling. Sequestration of carbon from atmospheric CO2, in extensive, cold organic soils and the high albedo from low, snow-covered vegetation have had imp

The economic development in the world today makes increased consumption of goods and travelling available for more people around the world than ever before. This results, however, also in increased production and spreading of substances that are hazardous both to human health and to the ecosystem globally. Therefore, education to increase knowledge, awareness, motivation, and action competence on

Comprehensive palliative care programs are often implemented on a community level, and to evaluate such interventions, randomization by cluster (community) may be the only feasible method. In trials randomizing individual subjects, the importance of proper concealment has been stressed, In cluster randomized trials, however, concealment of individual patient allocation is often impossible. The fol

We prove the existence of the old and metal-rich moving group HR 1614. This is done using the new Hipparcos parallaxes in combination with metallicities derived from Strömgren photometry, supported by dynamical simulations of the evolution of old moving groups in the galactic potential. A new selection criterion for this moving group is presented as well as a new, extended sample of probable membe

Purpose - This paper aims to illustrate a new method to cluster consumer attribute preferences and to transform spontaneously written texts by consumers about a certain favourite food product (hamburger) into distinct preference clusters of attributes. Design/methodology/approach - A new way of finding significant clusters of consumer attribute preferences is developed by means of a new text analy

Popular Abstract in Swedish Hjärnan är ett energikrävande organ och förbrukar ca 20% av blodets syre trots att den bara utgör 1-2% av kroppsvikten. Mitokondrien är den del av cellen där syre och näringsämnen förbränns till koldioxid och vatten, och mitokondrien kallas ofta för cellens kraftstation. Denna process, den så kallade cellandningen, är kopplad till produktion av den energirika molekylen There is currently no clinically available drug with neuroprotective properties to limit the evolving cell death following e.g. stroke or traumatic brain injury. The mitochondrial permeability transition (mPT) is a potential pathological mechanism causing cell death in the CNS. As the name implies, the mPT is defined by a sudden increase in permeability of the inner mitochondrial membrane, whose n

Purpose: To assess the additional value of subtraction ictal single-photon emission computed tomography (SPECT) coregistered to MRI (SISCOM) for localization of the epileptogenic zone in patients with drug-resistant epilepsy scheduled for invasive video-EEG (VEEG) before epilepsy surgery by a descriptive study from clinical practice. Methods: Forty-nine consecutive epilepsy patients between Januar

We have characterized 2 distinct mechanisms through which infectious agents may promote platelet adhesion and thrombus formation in flowing blood, thus contributing to the progression of disease. In one case, the process initiates when the integrin alpha(IIb)beta(3) mediates platelet arrest onto immobilized bacterial constituents that have bound plasma fibrinogen. If blood contains antibodies agai

The classical pathway of complement is crucial to the immune system, but it also contributes to inflammatory diseases when dys-regulated. Binding of the C1 complex to ligands activates the pathway by inducing autoactivation of associated C1r, after which C1r activates C1s. C1s cleaves complement component C4 and then C2 to cause full activation of the system. The interaction between C1s and C4 inv

Alzheimer's disease (AD) is strongly associated with loss of synapses. The complement system has been shown to be involved in synaptic elimination. Several studies point to an association between AD and the complement system. The purpose of this study was to examine the association of cerebrospinal fluid (CSF) levels of complement components 3 and 4 (C3 and C4, respectively), and complement recept

Background: Valid and reliable ischemic stroke subtype determination is crucial for well-powered multicenter studies. The Causative Classification of Stroke System (CCS, available at http://ccs.mgh.harvard.edu) is a computerized, evidence-based algorithm that provides both causative and phenotypic stroke subtypes in a rule-based manner. We determined whether CCS demonstrates high interrater reliab

Fracture Liaison Services are the best model to prevent secondary fractures. The International Osteoporosis Foundation developed a Best Practice Framework to provide a quality benchmark. After a year of implementation, we confirmed that a single framework with set criteria is able to benchmark services across healthcare systems worldwide. Introduction Despite evidence for the clinical effectivenes

Popular Abstract in Swedish Energianvändningen i världen måste minska drastiskt inom en snar framtid för att därmed minska utsläppen av växthusgaser och bromsa klimatförändringarna. Energi och handlande med energikällor har även blivit nationella säkerhetsfrågor. Inom Europeiska Unionen används ungefär 40% av den totala energianvändningen i byggnader, vilket innebär ungefär 36% av det totala koldiThe use of energy is a major global issue both according to climate changes but also in the aspect of national safety tied to the trade with energy sources. Of the total energy use in the member states of the European Union, about 40% is used in residential and commercial buildings. Passive houses are one way to reduce the energy use in buildings and at the same time keep a good indoor comfort. Th

Background: There is a need for ecient regression testing in most software development organizations. Often the proposed solutions involve automation. However, despite this being a well researched area, research results are rarely applied in industrial practice. Aim: In this paper we aim to bridge the gap between research and practice by providing examples of how evidence-based regression testing

Popular Abstract in Swedish Analysen av källornas uppgifter om uppbyggnadsfasen av de väpnade styrkorna under Muhammad och hans efterföljare kaliferna fram till 680 ger vid handen, att vi här har att göra med en organisation som stod på en likvärdig nivå med sina fiender i ledningsmässigt, strategiskt och taktiskt hänseende. Angreppet på de östromerska provinserna Palestina I-III och Arabia visar In the present work I have studied how the armed forces under Muhammad and the first caliphs were built up and how they operated in the period 622-80. The perspective is that of the history of religion and strategic theory, and comparisons are made with both contemporary and more recent material. The concept of "Strategic surprise attack" formed an important part of the campains that the generals