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Using population-based data from Sweden, we identified all multiple myeloma (MM) patients (n = 8740) and 5652 monoclonal gammopathy of undetermined significance (MGUS) patients diagnosed between 1986 and 2005. We calculated standardized incidence rates (SIRs) for all subsequent hematologic and nonhematologic malignancies for MM patients diagnosed before/after 1995 (introduction of high-dose melpha

Differentiated thyroid carcinoma (TC) is threefold more common in women than in men and, therefore, a role of female hormones in the etiology of differentiated TC has been suggested. We assessed these hypotheses in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Among 345,157 women (mean age 51) followed for an average of 11 years, 508 differentiated TC cases were i

At present, it is difficult to determine whether glycemic index (GI) is an important tool in the prevention of lifestyle diseases, and long-term studies investigating GI with diets matched in macronutrient composition, fiber content, energy content, and energy density are still scarce. We investigated the effects of 2 high-carbohydrate (55%) diets with low GI (LGI; 79) or high GI (HGI; 103) on pos

Prospective cohort studies about cutaneous melanoma (CM) risk are still few. Host factor- and UVR exposure data were collected prospectively by questionnaire in this population-based cohort study including 40000 Swedish born women, aged 25-64 years at enrolment (1990). Risk for CM (Cox regression and Stepwise Cox regression [SCR], hazard ratios [HRs] with 95 % Confidence Intervals [CI]) in relatio

Rationale: Cardiovascular drugs may improve survival in chronic obstructive pulmonary disease (COPD). However, previous studies did not account for major sources of bias, and drug effects have not been evaluated in severe COPD. Objectives: To estimate the time-dependent effects of cardiovascular drugs on survival in oxygen-dependent COPD, accounting for immortal and immeasurable time bias. Methods

Liquid-crystalline cubic-phase nanoparticles (CPNPs) (known as Cubosome particles), based on the lipid glycerol monooleate and stabilized by the nonionic block copolymer Pluronic F-127, interact with supported model membranes consisting of dioleoylphosphatidylcholine (DOPC) in a complex and dynamic fashion. Neutron reflectivity measurements on the interaction of CPNPs with bilayers of different co

BACKGROUND. Understanding the genetic architecture of cardiac structure and function may help to prevent and treat heart disease. This investigation sought to identify common genetic variations associated with inter-individual variability in cardiac structure and function. METHODS. A GWAS meta-analysis of echocardiographic traits was performed, including 46,533 individuals from 30 studies (EchoGen

Background: Low-dose opioids can relieve breathlessness but may be underused in late-stage COPD due to fear of complications, contributing to poor symptom control. Objectives: We aimed to study the period prevalence and indications of opioids actually prescribed in people with end-stage COPD. Methods: The study was a longitudinal, population-based study of patients starting long-term oxygen therap

BACKGROUND: Biomarkers reflecting diverse pathophysiological pathways may play an important role in the pathogenesis of abdominal aortic aneurysm (aortic diameter ≥30 mm, AAA), levels of many biomarkers are elevated and correlated to aortic diameter among 65-year-old men undergoing ultrasound (US) screening for AAA.PROBANDS AND METHODS: To evaluate potential relationships between biomarkers and ao

Aims: This study aims to describe the development of a Cerebral Palsy Follow-up Registry in Jordan (CPUP-Jordan) and to provide a baseline child and parent demographic information, birth history of the child participants, and distribution of the participants based on topographical distribution of cerebral palsy (CP) and functional classification systems. Methods: The CPUP-Jordan was developed usin

Phosphodiesterase-5 inhibitors are commonly used in pulmonary arterial hypertension but, as suggested by the RESPITE study, phosphodiesterase-5 inhibitor therapy (mono-/combination) does not always have a satisfactory treatment effect. This study aimed to investigate the clinical course of pulmonary arterial hypertension patients not at treatment goal after at least 90 days of treatment with phosp

Syftet med detta examensarbete har varit att undersöka täckningsprincipen i svensk rätt, med ett särskilt fokus på dess tillämpning när ansvar för medhjälp aktualiseras. Målet har varit att försöka utreda dels vilka krav gällande rätt uppställer vid uppsåtstäckningen vid medhjälp och dels bidra med ett normativt perspektiv genom att granska gällande rätt ur ett konformitets- och skuldperspektiv. D

Amphibian populations are declining globally due to several abiotic factors such as climate, pH, water permanence and biotic factors including predation by exotic species, competition and the spread of diseases. Habitat destruction caused by humans is also an important factor. Several species of amphibian have been declining in Sweden, and in most cases explained by habitat destruction and isolati

Vilka mangroverötter vill marina djur helst bo på? Stora delar av världens tropiska kuster är bevuxna av mangrove. Här vadar träden i vattnet och skjuter hela tiden ut nya luftrötter för att ta över ytterligare en bit hav. Inte så många skulle få för sig att snorkla på en sådan här plats. Gör man ändå det möts man, åtminstone i Karibien, av en explosion av färger och liv. Alger och mängder av fasEffect of habitat heterogeneity on marine epibiont assemblages associated with mangrove roots In coastal forests of red mangrove, prop roots extend into the seawater and serve as substrate for assemblages of algae and sessile marine organisms. These assemblages exhibit extreme variability on very small special scales – two neighbouring prop roots might be colonized by completely distinct assembla

Abstract Background: As the population ageing increases, the dramatic rise in cognitive disorders such as mild cognitive impairment and dementia has become a public health priority. Mobile health technology is a unique non-pharmacological intervention for dementia and cognitive disorders. A digital platform (Support Monitoring and Reminder for Mild Dementia: SMART4MD) is created for persons with m

Created in the aftermath of the Second World War the United Nations and its bodies do not represent the world that we live in today. The effectiveness and the usefulness of the organisation have been questioned and the need for a reformation has increased. The distinction between power and authority and the different organs of the UN is difficult to draw. The Security Council has the main responsi

BACKGROUND: Screening immigrant mothers for postpartum depression has been shown to be challenging for health care professionals in handling cultural implications of postpartum depression, communicating through interpreter and applying translated versions of the screening scale.AIM: The aim of the study was to test the feasibility of an evidence-based educational intervention for Child Health Serv

Objectives: To determine clinical characteristics, outcome and occurrence of comorbidities in patients with biopsy-confirmed giant cell arteritis (GCA) treated with intravenous methylprednisolone (IVMP) vs those receiving oral glucocorticoids (OGC) only. Methods: A retrospective study included patients with GCA diagnosed from 2004 through 2019. Clinical and laboratory characteristics, and cumulati

I februari 2023 meddelade Högsta domstolen två avgörande domar angående bevisvärdering av indiciebevisning. Dessa domar har utlöst en debatt om bevisvärdering av indicier, inklusive chattmeddelanden och vittnesutsagor. I ljuset av en ökad debatt om rättvisa och rättssäkerhet, samt inflytandet av teknologin i rättssystemet, ägnas denna uppsats åt att undersöka hur domstolar bedömer chattmeddelandenIn February 2023, the Supreme Court announced two landmark judgments concerning the evaluation of circumstantial evidence. These rulings triggered a debate on the assessment of circumstantial evidence, including chat messages and witness testimonies. Considering an escalating discourse on justice, legal security, and the influence of technology in the legal system, this essay delves into examining

Sverige elektrifierar i snabb takt, vilket driver en stor energiomställning där förnybara energikällor som vind- och solkraft spelar en nyckelroll. Dessa medför väldigt lite koldioxidutsläpp och är ett nödvändigt steg mot ett mer hållbart samhälle. Men är det verkligen så enkelt som att bara bygga mer vind- och solkraft - och kan vi förvänta oss samma robusta och pålitliga elförsörjning som vi tidThe electric power system is undergoing a major change through the implementation of a large number of variable renewable energy sources (VRE), driven by the goal to reduce carbon-dioxide emissions from electricity production. This transition increases the need for a more flexible and dynamic power system capable of maintaining voltage and frequency stability under changing operating conditions. U