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A flat-well microformat competitive enzyme-linked immunosorbent chemiluminescent assay for the detection of the pesticide 2,4-dichlorophenoxyacetic acid (2,4-D) is described. Thick-film technology was used to pattern a hydrophobic layer 100 μm thick onto glass microscope slides to form an array of 2 × 2 mm2 squares. These flat wells were able to hold 2 μL of reagents, corresponding to a heig
Purpose: To describe nurses' experiences encountering children with suspected neurodevelopmental disorders in Child Health Services. Design and methods: This qualitative inductive study was conducted in Sweden. Twenty nurses were interviewed individually on a virtual platform using a semi-structured interview guide with open-ended and explorative questions. Interviews were audio recorded and trans
BACKGROUND: Smartphones have made it possible for patients to digitally report symptoms before physical primary care visits. Using machine learning (ML), these data offer an opportunity to support decisions about the appropriate level of care (triage).OBJECTIVE: The purpose of this study was to explore the interrater reliability between human physicians and an automated ML-based triage method.METH
In Parkinson’s disease, there is an accumulation of α-synuclein (SYN) aggregates in neurons, which is promoted by neuroinflammation. In neural cells, cytokine-induced SYN aggregation is modulated by heparan sulfate (HS) derived from glypican-1 (GPC1) by amyloid precursor protein (APP) and nitric oxide (NO)-dependent cleavage. We have explored possible interplay between APP, GPC1, and SYN in undiff
Currently, the inner dynamics of teacher identity transformations remain a “black box.” Conceptualizing preservice teacher identity as a complex dynamic system, and the notion of “being someone who teaches” in dialogical terms as involving shifts between different teacher voices, the study investigates the dynamical processes at play when transitions between identities occur. Using a single-case d
Background: Complex level-of-care decisions involve uncertainty in which decisions are beneficial for older patients. Knowledge of physicians’ decision-making during acute situations in older patients’ homes is limited. Therefore, this study aimed to describe physicians’ experiences and actions in making complex level-of-care decisions during the assessment of older patients in acute situations wi
Popular Abstract in Swedish Anglo-amerikanska relationer efter andra världskriget bestod både av samarbete och konflikt. Ett exempel på det första var Pentagondiskussionerna 1947 då ett amerikanskt uttalande betonade det generella målet att upprätthålla säkerheten i Mellanöstern genom att stödja de brittiska politiska, ekonomiska och strategiska positionerna i området. Ett exempel på det senare va
The aim of this study was to determine the association between childhood insulin-dependent diabetes mellitus (IDDM) and HLA-DR4 subtypes and to test in a population-based investigation whether the DR4 association has an effect independent to that of DQ. First, HLA genotyping identified DR4 in 337/425 (79%) patients and 148/367 (40%) controls (Odds Ratio 5.67; p < 0.01). Second, a total of 14 DR4 s
The incorporation of a free fatty acid into the sn-1 position of phosphatidylcholine by lipase-catalyzed transesterification was investigated. The thermodynamic water activity of both the enzyme preparation and the substrate solution was adjusted to the same value prior to the reaction. The reaction rate increased with increasing water activity but the yield of modified phosphatidylcholine decreas
The Natura 2000 network of protected sites is one of the means to enable biodiversity conservation in Europe. EU member states have to undertake surveillance of habitats and species of community interest protected under the Habitat Directive. Remote sensing techniques have been applied successfully to monitor biodiversity aspects according to Natura 2000, but many challenges remain in assessing dy
Background:Nurses and physicians in nephrology settings provide care for patients with end-stage kidney disease receiving hemodialysis treatment along a complex illness trajectory.Aim:The aim was to explore physicians’ and nurses’ perspectives on the trajectories toward the end of life involving decisions regarding hemodialysis withdrawal for patients with end-stage kidney disease.Research design
The draft Post-2020 Global Biodiversity Framework commits to achievement of equity and justice outcomes and represents a “relational turn” in how we understand inclusive conservation. Although “inclusivity” is drawn on as a means to engage diverse stakeholders, widening the framing of inclusivity can create new tensions with regard to how to manage protected areas. We first offer a set of tensions
In recent years, human dihydroorotate dehydrogenase inhibitors have been associated with acute myelogenous leukemia as well as studied as potent host targeting antivirals. Starting from MEDS433 (IC50 1.2 nM), we kept improving the structure-activity relationship of this class of compounds characterized by 2-hydroxypyrazolo[1,5-a]pyridine scaffold. Using an in silico/crystallography supported desig
The purpose of this chapter is to identify and classify proposed business model innovation tools through a literature review of academic publications. We classified the tools into three categories: innovation process stage, strategic objective and size of firm. Our main findings are that the overall number of business model innovation (BMI) tools described in the research literature is limited mos
Real-time train arrival time prediction is crucial for providing passenger information and timely decision support. The paper develops methods to simultaneously predict train arrival times at downstream stations, including direct multiple output liner regression (DMOLR) and seemingly unrelated regression (SUR) models. To capture correlations of prediction equations, two bias correction terms are t
Purpose: The use of prophylaxis for thromboembolism and infection in anterior cruciate ligament (ACL) reconstruction is not well documented and no general guidelines have been established. The aim of this study was to evaluate the ACL surgeons’ individual strategies of thromboprophylaxis, use of prolonged antibiotic prophylaxis and vancomycin-soaked ACL grafts, and if its use is supported in the c
Both in the social and natural sciences, methodologies have been developed to deal with relatively stable conditions, where findings can be validated based on past experiences. At a time when both social and natural phenomena are rapidly changing, new approaches are urgently needed to produce knowledge for systemic change, inform high-stakes decisions, and enable sustainability transitions in the
In this paper I will discuss interactivity and spatiality, including the relationships between technology-in-use, design and everyday practices. The paper reports some initial experiences from a field study at a technology-intensive control room and of using work-oriented approaches for collaborative design. In several studies a group of multidisciplinary researchers has carried out experiments of
