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Target-controlled infusion (TCI) constitutes a clinically available alternative to manually administering the infusion rate of the anesthetic drug propofol. In TCI, a drug infusion profile is optimized to track a reference trajectory of blood plasma or effect site (brain cortex) drug concentration, or a corresponding clinical effect. TCI is a pure feed-forward openloop strategy, fully reliant on a
PURPOSE: Preoperative percutaneous transabdominal wall biopsy may be considered to diagnose gastrointestinal stromal tumour (GIST) and plan preoperative treatment with tyrosine kinase inhibitors when an endoscopic biopsy is not possible. Hypothetically, a transabdominal wall biopsy might lead to cell seeding and conversion of a local GIST to a disseminated one. We investigated the influence of pre
BACKGROUND: Empirical knowledge around palliative care provision and needs of people with intellectual disabilities is extremely limited, as is the availability of research resources, including expertise and funding. This paper describes a consultation process that sought to develop an agenda for research priorities for palliative care of people with intellectual disabilities in Europe.METHODS: A
Landscape simplification and habitat fragmentation may cause severe declines of less mobile and habitat specialist species and lead to biotic homogenization of species communities, but large-scale empirical evidence on biotic homogenization remains sparse. We sampled butterfly and day-active geometrid moth communities within 134 differently fragmented landscapes in Finland situated in five geograp
An important part of responsible business practices is compliance with the law. This article details what actually happens when the laws of the host country fail to ensure adequate protection. The focus here is on land dispossession and loss of livelihood in relation to a gold mine project in central Ghana. How is it that a well-known international company—Newmont—with its own corporate social res
Introduction: Approximately 25% of colon cancer (CC) patients having curative surgery will relapse. Therefore, it is crucial to identify patients with increased recurrence risk to offer them adjuvant chemotherapy. Three markers with prominent expression in fibroblasts: forkhead box Q1 (FOXQ1), matrix metalloproteinase-11 (MMP11), and thrombospondin-2 (THBS2), and the fibroblast expressed chemokine
Variable selection properties of procedures utilizing penalized-likelihood estimates is a central topic in the study of high-dimensional linear regression problems. Existing literature emphasizes the quality of ranking of the variables by such procedures as reflected in the receiver operating characteristic curve or in prediction performance. Specifically, recent works have harnessed modern theory
Objectives: Women living with HIV are underrepresented in clinical trials assessing outcomes of antiretroviral treatment (ART), justifying the need for observational studies. We investigated differences in viral non-suppression between women and men in the Swedish InfCareHIV cohort and analysed results in relation to biological and socio-demographic variables and patient-reported outcome measures
Body-focused repetitive behavior disorders, including trichotillomania (hair-pulling disorder) and excoriation (skin picking) disorder, typically emerge in early adolescence, but little is known about the clinical characteristics and treatment outcomes of these disorders in young people, particularly in real-world clinical settings. Participants were 63 children and adolescents (51 girls; age rang
BACKGROUND: Low-level viremia during antiretroviral therapy (ART) has been associated with inferior outcomes, but knowledge on the impact of low-level viremia in the current era of dolutegravir-based ART in low-income countries is limited.OBJECTIVE: To investigate whether low-level viremia predicts virologic non-suppression and attrition from care in people with HIV receiving ART in Ethiopia.METHO
While pesticide use is subject to strict regulatory oversight worldwide, it remains a main concern for environmental protection, including biodiversity conservation. This is partly due to the current regulatory approach that relies on separate assessments for each single pesticide, crop use, and non-target organism group at local scales. Such assessments tend to overlook the combined effects of ov
Prostate Cancer Diagnosis and Treatment Enhancement through the Power of Big Data in Europe (PIONEER) is a European network of excellence for big data in prostate cancer. PIONEER brings together 34 private and public stakeholders from 9 countries in one multidisciplinary research consortium with the aim of positively transforming the field of prostate cancer clinical care by answering pressing que
In this thesis, the fluid dynamic properties of the conventional Rushton turbine and another impeller type, the Scaba Radial flow Gas dispersing Turbine (with six concave blades) are compared. For comparison, point-wise velocity measurements were made in the discharge of the two turbine types using Hot-Wire Anemometry in constant temperature mode (CTA) with a split film probe. For the time-average
Most furniture produced in a temperate climate, such as in Europe, does not have a long service life in warm and humid conditions. This means it is difficult to purchase furniture from temperate climates for export to tropical countries. This report discusses the problems and gives recommendations on how to choose materials and types of furniture construction for humid conditions. Wood and wood
Popular Abstract in Swedish De mest briljanta ljuskällor som finns idag är de så kallade synkrotronljuskällorna som kan generera ljus över ett mycket brett våglängdsspectrum, från synligt ljus ända till mycket korta våglängder - röntgenstrålar. Det existerar många sådana faciliteter runt om i världen och de används dagligen i olika experiment för att öka våra kunskaper om material på en mikrospopiThere is a strong desire for short wavelength (~1 Å), short pulsewidth (<100 fs), high-brightness, transverse and longitudinally coherent light pulses for use by the synchrotron radiation community. These requirements exceed the limits achievable by existing, so-called, "third-generation" light sources, such as the Advanced Photon Source (APS) at Argonne National Laboratory (ANL), USA, the Europea
The success of many modelling studies strongly depends on the availability of sufficiently long influent time series - the main disturbance of a typical wastewater treatment plant (WWTP) - representing the inherent natural variability at the plant inlet as accurately as possible. This is an important point since most modelling projects suffer from a lack of realistic data representing the infl
BACKGROUND: Screening immigrant mothers for postpartum depression has been shown to be challenging for health care professionals in handling cultural implications of postpartum depression, communicating through interpreter and applying translated versions of the screening scale.AIM: The aim of the study was to test the feasibility of an evidence-based educational intervention for Child Health Serv
Through biosilicification, organisms incorporate dissolved silica (dSi) and deposit it as biogenic silica (bSi), driving the silicon (Si) cycle in aquatic systems. While Si accumulation in marine picocyanobacteria has been recently observed, its mechanisms and ecological implications remain unclear. This study investigates biosilicification in marine and brackish picocyanobacteria of the Synechoco
Objectives: To determine clinical characteristics, outcome and occurrence of comorbidities in patients with biopsy-confirmed giant cell arteritis (GCA) treated with intravenous methylprednisolone (IVMP) vs those receiving oral glucocorticoids (OGC) only. Methods: A retrospective study included patients with GCA diagnosed from 2004 through 2019. Clinical and laboratory characteristics, and cumulati
We extend the ecological component (ECOGEM) of the carbon-centric Grid-Enabled Integrated Earth system model (cGEnIE) to include a diatom functional group. ECOGEM represents plankton community dynamics via a spectrum of ecophysiological traits originally based on size and plankton food web (phyto- and zooplankton; EcoGEnIE 1.0), which we developed here to account for a diatom functional group (Eco
