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Optimizing sample quantity and quality improves cost-effective and less invasive dendrochronological investigations. Our study examined 3,831 trees, including 2,921 pine, 404 spruce, and 506 oak trees. Pine had a 79.2% success rate for dating, spruce 46.5%, and oak 67.8%. Success rates increased with more trees analysed, notably in the case of spruce. When 1–3 spruce trees were analysed, only 44%

Despite the anticipated benefits of smart home technology (SHT) to support older adults' engagement in meaningful activities, barriers to the adoption of SHT have been identified. While research in the field of technology is surging, research on older adults playing an active role in designing and developing SHT to enhance usability is lacking. It is important to co-develop solutions to place olde

The ongoing climate change has been increasingly reflected in climate observations around the world, both in terms of averages and extremes, and attributed to anthropogenic climate forcing. When it comes to changing extremes, attribution to climate change is now especially well-established for heat-related extremes worldwide. Understanding changes in extremes is important for climate adaptation as

Neuroendocrine tumours (NETs) of the small intestine (siNET) are slow-growing malignancies often diagnosed at an advanced stage. Despite their indolent nature, patients frequently experience significant symptoms, including carcinoid syndrome (CS) with diarrhoea, which impact their health-related quality of life (HRQoL). This thesis investigates the determinants of HRQoL in siNET patients, its prog

Background: Patients with relapsing remitting multiple sclerosis (RRMS) treated with the high-efficacy drugs natalizumab (NTZ) or rituximab (RTX) generally show no evidence of disease activity. Currently, there is no head-to-head comparison between NTZ and RTX of neurodegenerative and neuroinflammatory biomarkers in cerebrospinal fluid (CSF). Objectives: To compare CSF biomarkers in a stable RRMS

Lignosulfonate, a macromolecular byproduct derived from the paper and pulp industry, is a promising feedstock for bioconversion processes due to its rich carbon content and widespread availability. We here present an approach for the production of muconic acid through the optimization of the oxidative depolymerization of lignosulfonate and its further conversion using a recombinant Pseudomona

One of the best systems for exploring the origin of enzyme catalysis has been the reaction of ketosteroid isomerase (KSI). Studies of the binding of phenolates to KSI have been taken as proof that the electrostatic preorganization effect only makes a minor contribution to the binding of the real, multiring, transition state (TS). However, our simulation study has determined that the difference bet

De nordliga höga latitudernas fysiska miljö, inklusive kryosfären i Arktis, har genomgått dramatiska förändringar under de senaste decennierna tack vare uppvärmning och andra klimatförändringar kopplade till antropogena utsläpp av växthusgaser. Uppvärmningen i regionen är ungefär det dubbla jämfört med ökningen i medeltemperaturen globalt. Globala klimatmodeller förutspår att denna förstärkta uppvThe physical environment in the northern high latitudes including the Arctic cryosphere has undergone dramatic changes due to anthropogenic greenhouse gas warming, which since pre-industrial times has been twice or more the rate of global mean warming. Global climate models predict that this accelerated warming will continue for at least the next few decades. Meanwhile, the arctic and subarctic ve

Popular Abstract in Swedish 2003 års Nobelpris i kemi gick till professor Peter Agre för upptäckten av aquaporinerna. Aquaporiner är proteiner som sitter i membran och bildar kanaler som tillåter vatten och andra små neutrala molekyler att passera genom membranet. Aquaporinerna utgör en mycket gammal och välkonserverad proteinfamilj som finns i alla levande organismer som hittills undersökts. VäxAquaporins, or Major Intrinsic Proteins (MIPs), are integral proteins that facilitate transport of water and other small neutral solutes across biological membranes. They belong to a well conserved and ancient family of proteins, present in all organisms ranging from bacteria to plants and humans. The aquaporin family in plants is large, indicating complex and regulated water transport within the

Myxofibrosarcoma (MFS) and undifferentiated pleomorphic sarcoma (UPS) are two common and aggressive subtypes of soft tissue sarcoma. The aim of this study was to assess potential transcriptomic differences between MFS and UPS tumours and to evaluate the extent to which differences in gene expression profiles were associated with genomic and clinical features. The study included 162 patients with t

Background: Little is known about whether the protective effect of marriage on alcohol use disorder (AUD) varies by cultural background. Aims: Using Swedish national data, we examined whether marriage is associated with a stronger reduction in AUD risk among Swedes of a Swedish background (i.e. those with two Swedish-born parents) compared to Swedes with a foreign background (i.e. one or two forei

Linear quadratic (LQ) control optimizes a quadratic cost function while following a linear model. It is commercially available in the process industry but often not labeled as such and infrequently used. Froth flotation is a process in the minerals industry that extracts precious metals from a slurry of finely ground rock in consecutive tanks called cells. Flotation cells are often arranged in two

We report the discovery and characterization of two sub-Saturns from the Transiting Exoplanet Survey Satellite (TESS) using high- resolution spectroscopic observations from the MaHPS spectrograph at the Wendelstein Observatory and the SOPHIE spectrograph at the Haute-Provence Observatory. Combining photometry from TESS, KeplerCam, LCOGT, and MuSCAT2, along with the radial velocity measurements fro

Motivation can be a decisive factor in students’ learning of a foreign language. At the same time, motivation is complex, dynamic, and context sensitive (Papi & Hiver, 2020). Language teachers encounter a wide spectrum of motivational profiles among their students and need to understand the motivation process to find strategies to address students' varying levels of motivation at a given time.

BACKGROUND: Patients undergoing hepato-pancreato-biliary surgery are typically preoperatively assessed using the American Society of Anesthesiologists (ASA) classification, which is also used for case-mix adjustment when comparing centre outcomes. Studies determining the inter-rater variability of the ASA classification within hepato-pancreato-biliary surgery are currently lacking.METHODS: An inte

Let μ be a positive measure supported on a planar domain Ω. We consider the behavior of the balayage measure ν:=Bal(μ,∂Ω) near a point z0∈∂Ω at which Ω has an outward-pointing cusp. Assuming that the order and coefficient of tangency of the cusp are d>0 and a>0, respectively, and that dμ(z)≍|z-z0|2b-2d2z as z→z0 for some b>0 (here d2z is the Lebesgue measure on C), we obtain the leading order term

Background: 25-hydroxyvitamin D3 (25(OH)D3) affects immune function, bone health, and reproduction. The precursor of 25(OH)D3, vitamin D3, is synthesized upon ultraviolet (UV) radiation exposure, the levels of which vary. Methods: In a one-year observational study, we used multiple statistical approaches to examine 25(OH)D3 metabolism and UV exposure in 217 healthy men (aged 30–50 years) not using

PurposeTürkiye ranks among the highest in antibiotic consumption within OECD countries and faces growing challenges from multidrug-resistant uropathogens. Nationwide, resistance-guided treatment data remain scarce. The main objective of this work is to provide a comprehensive nationwide data on antibiotic resistance patterns among uropathogens to guide treatment options in urinary tract infections