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There are many ways to acquire and process diffusion MRI (dMRI) data for group studies, but it is unknown which maximizes the sensitivity to white matter (WM) pathology. Inspired by this question, we analyzed data acquired for diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) at 3T (3T-DTI and 3T-DKI) and DTI at 7T in patients with systemic lupus erythematosus (SLE) and healthy c

Physiotherapists are facing complex health challenges in the treatment of persons suffering from long-lasting musculoskeletal disorders and mental health problems. Basic Body Awareness Therapy (BBAT) is a physiotherapy approach within the movement awareness domain developed to bridge physical, mental, and relational health challenges. The purpose of this study was to reach a consensus on core phen

Bicuspid aortic valve (BAV) is the most common congenital cardiac abnormality, occurring in 1% to 2% of the general population. Adults with degenerative aortic valve (AV) disease have been shown to have an elliptical shaped AV annulus. The goal of this study was to investigate the shape of the aortic annulus in children with BAV, coarctation of the aorta (CoA) with or without BAV, and normal contr

At the southern margin of permafrost in North America, climate change causes widespread permafrost thaw. In boreal lowlands, thawing forested permafrost peat plateaus (‘forest’) lead to expansion of permafrost‐free wetlands (‘wetland’). Expanding wetland area with saturated and warmer organic soils is expected to increase landscape methane (CH4) emissions. Here, we quantify the thaw‐induced increa

AIM: Epidural analgesia reduces the surgical stress response. However, its effect on pro- and anti-inflammatory cytokines in the genesis of inflammation following major abdominal surgery remains unclear. Our main objective was to elucidate whether perioperative epidural analgesia prevents the inflammatory response following colorectal cancer surgery.METHODS: Ninety-six patients scheduled for open

The scFv antibody towards the Burkholderia pseudomallei exotoxin was previously constructed by phage display and exhibited good specificity towards the exotoxin. We report here the optimization of the scFv expression in an E. coli expression system. Four different E. coli strains (ER2537, TG1, HB2151, and XL1-Blue) were examined for optimal expression of the scFv protein. Two types of carbon sourc

Background: We set out to estimate net survival trends for 10 common cancers in 279 cancer registry populations in 67 countries around the world, as part of the CONCORD-2 study. Net survival can be interpreted as the proportion of cancer patients who survive up to a given time, after eliminating the impact of mortality from other causes (background mortality). Background mortality varies widely be

Aim: Understanding how climate conditions influence plant–pollinator interactions at the global scale is crucial to understand how pollinator communities and ecosystem function respond to environmental change. Here, we investigate whether climate drives differences in network roles of the main insect pollinator orders: Diptera, Coleoptera, Lepidoptera and Hymenoptera. Location: Global. Time period

Background: The neurobiological origins of the early and predominant behavioral changes seen in the behavioral variant of Alzheimer’s disease (bvAD) remain unclear. A selective loss of Von Economo neurons (VENs) and phylogenetically related neurons have been observed in behavioral variant frontotemporal dementia (bvFTD) and several psychiatric diseases. Here, we assessed whether these specific neu

The main purpose of this brief reflection is to examine the relationship between (a) Muslim communal values of neighborliness, mutual support and responsibility for those living together in a defined, spacial community and b)the built environment and structures of mosques and community gathering spaces, with a focus on how the existence of such a built environment and infrastructure helps to devel

BACKGROUND: In Bangladesh, diarrhoea in children under-five is a major public health problem with cost implications. Although under-five diarrhoea mortality and morbidity have declined from 2007 to 2018, change in the economic burden is unknown. This study determined the change in the societal economic burden of under-five diarrhoea in Bangladesh comparing 2007 to 2018.METHODS: A prevalence-based,

Due to higher demands on the electrical systems in the aviation industry, the generation and distribution of electrical power, in aircrafts, needs to be researched and developed further. Key requirements include increased power capacity to meet future demands, a transition from AC to DC supply and an increased voltage level. For power generation, a generator is coupled to the jet turbine which mus

Studiens syfte var att psykometriskt utprova en svenskspråkig version av Hayling Test, ett neuropsykologiskt test som framför allt avser att mäta verbal inhibitionsförmåga. Testet utprovades på en frisk kontrollgrupp (N = 76) i åldern 40-95 år. Studien fann ett signifikant negativt samband mellan ålder och prestationer på testet. Män presterade signifikant bättre än kvinnor på ett av delmåtten. DeThe aim of this study was to examine the psychometric properties of an adapted Swedish version of the Hayling Test, a neuropsychological test which mainly intends to measure response inhibition. The test was administered to a healthy control group (N = 76) ranging in age from 40 to 95 years. The study found a significant negative correlation between age and test performance. Men performed signific

Introduction: This study evaluated lipid identification using mass spectrometry. Background: Three main modes of acquisition are used in mass spectrometry of lipids; data-independent acquisition (DIA), data-dependent acquisition (DDA) and targeted acquisition. DIA is the most including one, yielding a complete but complex data set, while targeted is the least including one, basing acquisition on

Urbanisering med växande och tätare städer i kombination med klimatförändring som förväntas kunna ge extremare väder kräver ett smart markanvändande där flera funktioner kan uppfyllas på samma yta. Ett exempel på en multifunktionell anläggning är skelettjordskonstruktioner som har en bärförmåga som hanterar ovanliggande laster, skapar gynnsamma förhållanden för träd och hanterar dagvatten med reniUrbanization with growing and denser cities in combination with climate change that is expected to produce more extreme weather requires a smart land use where several functions can be fulfilled on the same surface. An example of a multifunctional facility is structural soil that have a bearing capacity to handle loads, create favorable conditions for trees and handle stormwater with purification

Prenatal testosterone surge is considered crucial for physiological masculinization of male progeny. Disorders in sex steroid hormone balance during the fetal development may interfere with male reproductive health later in life. In this study, we have investigated in utero and in vitro effects of flutamide (FLU) and diethylstilbestrol (DES) on fetal rat testicular steroidogenesis. In utero exposu

OBJECTIVE - We assessed the association between A1C and cardiovascular diseases (CVDs) in an observational study of patients with type 1 diabetes followed for 5 years. RESEARCH DESIGN AND METHODS - A total of 7,454 patients were studied from the Swedish National Diabetes Register (aged 20-65 years, diabetes duration 1-35 years, followed from 2002 to 2007). RESULTS - Hazard ratios (HRs) for fatal/n

Background: Blood lead concentrations (B-Pb) were measured in 3 879 Swedish school children during the period 1978-2007. The objective was to study the effect of the proximity to lead sources based on the children's home and school location. Methods: The children's home address and school location were geocoded and their proximity to a lead smelter and major roads was calculated using geographical