Filtyp
We provide a detailed account of the origin and establishment of the Osteoarthritis Research Society International (OARSI) and celebrate its history from inception to the current day. We discuss the mission, vision and strategic objectives of OARSI and how these have developed and evolved over the last 3 decades. We celebrate the achievements of the society as we approach its 30th birthday, honor
The delivery of ibuprofen into and through the skin from novel formulations containing TEMPO-oxidized cellulose nanofibril-based (TOCN) gels was compared to that from two conventional and commercially available products. The gels were evaluated in-vitro (using both silicone membranes, and pig skin) and in-vivo in human volunteers. All gels showed consistent behaviour in a standard in vitro release
Two-dimensional (2D) topological insulators have fascinating physical properties which are promising for applications within spintronics. In order to realize spintronic devices working at room temperature, materials with a large nontrivial gap are needed. Bismuthene, a 2D layer of Bi atoms in a honeycomb structure, has recently attracted strong attention because of its record-large nontrivial gap,
This study investigates how the brain encodes episodic events to support diverse memory functions. Thirty-six participants viewed movies simulating real-life interactions while EEG was recorded. They first watched movies featuring two characters (AB), followed by scenes where one original character interacted with a new one (BC). Memory was assessed for direct (AB and BC), indirect (AC) associatio
Design thinking is an innovative methodology that may be applied by small and medium enterprises which emphasizes a human-centered approach to problem-solving, facilitating the creation of novel solutions for complex and open-ended challenges like the development of new products. Despite its recognized importance in business and academia, many industrial SMEs struggle with applying design thinking
Evidence that a 1,2-dihydroxycyclohexadienide anion is stabilized by aromatic "negative hyperconjugation" is described. It complements an earlier inference of "positive" hyperconjugative aromaticity for the cyclohexadienyl cation. The anion is a reactive intermediate in the dehydration of benzene cis-1,2-dihydrodiol to phenol. Rate constants for 3-substituted benzene cis-dihydrodiols are correlate
Once surface active colloids, such as microgels, adsorb to an interface, they modify the viscoelastic properties of the interface. In contrast to what happens in bulk, the elastic properties have a non-monotonic dependence on the generalized area fraction. In this study, we describe this phenomena by performing molecular dynamic simulations of effective pair potentials in two dimensions. Our poten
Abstract: Secure base scripts are implicit schemas that guide perceptions, responses, and interactions by encapsulating expectations of support from attachment figures during distress. The current study investigated the impact of early institutional rearing and the causal effects of high-quality foster care following early deprivation on secure base scripts in adolescents who had experienced sever
This study examines how people with lived experiences of crime describe processes of entry into and exit from criminality. Furthermore, the study analyses how social bonds, turning points, and key life experiences are given meaning, and how the functions of criminality can be understood through the participants' life narratives. With a symbolic interactionist perspective, the analysis is made
Based on toxicological evidence, human exposure to phthalates (PHs) and diisononylcyclohexane-1,2-dicarboxylate (DINCH) may contribute to adverse health effects, especially during vulnerable developmental stages. To support the exposure assessment for this group of endocrine disruptors, we developed and validated a method for the analysis of 14 PH and 3 DINCH metabolites in human urine and materna
Primary care professionals are often the first line of support for children and adolescents with tic disorders. However, families often report feeling inadequately supported and perceive a lack of knowledge about tics. Few studies have examined primary care professionals’ perspectives on managing tic disorders. This study explored how these professionals understood and managed tic disorders in a D
Följande uppsats analyserar det straffrättsliga ansvaret vid olyckor orsakade av självkörande fordon. Dessa självkörande fordon styrs av avancerade artifi-ciella algoritmer som fattar autonoma beslut, vilket utmanar straffrättens grundläggande krav och principer. Bland annat blir maximet ”nulla poena sine culpa” (inget straff utan skuld) lidande när beslutsprocessen i gärningsögon-blicket saknar tThe following thesis analyzes criminal liability in accidents caused by self-driving vehicles. These autonomous vehicles are governed by advanced artifi-cial algorithms that make autonomous decisions, which challenges the funda-mental requirements and principles of criminal law. Among other things, the maxim "nulla poena sine culpa" (no punishment without guilt) suffers when the decision
Aims: Pain and poor health-related quality of life measures serve as the primary indication for primary elective total hip arthroplasty (THA). It remains challenging to predict whether THA delivers the patient-anticipated improvements. Our study aimed to develop and validate statistical and machine learning prediction models of one-year clinical improvement in patient-reported outcome measures (PR
This study explores the effectiveness of combining Electrical Resistivity Tomography (ERT) and Induced Polarization (IP) for identifying internal erosion processes in embankment dams. A small-scale test dam was built in Älvkarleby, Sweden, with deliberately embedded but undisclosed defects to test monitoring capabilities. Daily ERT and IP measurements were collected during 4.5-year years, and anal
AIM: This study investigated childhood diagnoses in children born extremely preterm before 24 weeks of gestation.METHODS: Diagnoses of neurodevelopmental disorders and selected somatic diagnoses were retrospectively retrieved from national Swedish registries for children born before 24 weeks from 2007 to 2018. Their individual medical files were also examined.RESULTS: We studied 383 children born
PURPOSE: To evaluate retinal function in children taking vigabatrin and to explore the influence of age and dose parameters on the results of full-field electroretinography (ff-ERG).METHODS: The ff-ERGs from 14 children receiving vigabatrin were compared with ff-ERGs from healthy controls. Treated children were further grouped according to age (pre-school = 12-71 months; older = 72-228 months). Pa
Introduction: Galectin-3 is a pro-fibrotic β-galactoside binding lectin highly expressed in fibrotic liver and implicated in hepatic fibrosis. Selvigaltin (previously known as GB1211) is a novel orally active galectin-3 small molecule inhibitor that has high affinity for galectin-3 (human KD = 25 nM; rabbit KD = 12 nM) and high oral bioavailability in rabbits and man. In this study the efficacy of
The present study aims at modeling and analyzing the climate change effects on the runoff of the Rheraya stream (Morocco), taking into account the snow component. For this purpose, we combined the GR4J conceptual rainfall-runoff model with the CemaNeige snow module calibrated over 1989–2009, for daily time step simulations. Med-Cordex climate projections for the period 2020–2040 were used to simul
Background: The aims of this study are to 1) determine the scope of musculoskeletal (MSK)-related clinical research in Sweden; 2) collate the amount of first-tier funding received; 3) discuss strategies and infrastructure supporting future MSK clinical trials in Sweden. Methods: A systematic scoping review protocol was applied in PubMed, Scopus, and SweCRIS databases. The articles were examined, a
Purpose of Review: Producing wood of the right quality is an important part of forest management. In the same way that forest growth models are valuable decision support tools for producing desired yields, models that predict wood quality in standing trees should assist forest managers to make quality-influenced decisions. A challenge for wood quality (WQ) models is to predict the properties of po
