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Familial Platelet Disorder with associated Myeloid Malignancy (FPDMM, FPD/AML, RUNX1-FPD), caused by monoallelic deleterious germline RUNX1 variants, is characterized by bleeding diathesis and predisposition for hematologic malignancies, particularly myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Clinical data on FPDMM-associated AML (FPDMM-AML) are limited, complicating evidence

Denna avhandling undersöker den svenska befolkningens attityder i förhållande till en ekosocial agenda utifrån ett hållbart välfärdsperspektiv. Forskare har länge angripit frågor om miljö och välfärd som två separata fält. De aktuella miljö- och klimatförändringarna visar dock att dessa två fält måste förstås i samklang med varandra om vi ska kunna ställa om till ett klimatneutralt samhälle där håThis thesis explores Swedish residents’ attitudes related to an eco-social agenda from a sustainable welfare perspective. It investigates public support for general policy goals related to an eco-social agenda as well as for specific eco-social policies. The thesis also analyses the significance of the individuals’ socioeconomic characteristics, their values, and the context they are situated in r

Objectives: The prevalence of several autoimmune diseases, including thyroid dysfunction, has been reported to be increased in patients with endometriosis. Upregulated thyroid stimulation hormone (TSH) receptors in ectopic endometrium and elevated serum titers of TSH receptor antibodies (TRAb) IgG in endometriosis patients indicates an overlap in pathophysiology. However, cross-reactivity with oth

Background: Chiropractic maintenance care (MC) has been found to be effective for patients classified as dysfunctional by the West Haven-Yale Multidimensional Pain Inventory (MPI). Although displaying good psychometric properties, the instrument was not designed to be used in clinical practice to screen patients for stratified care pathways. The aim was to develop a brief clinical instrument with

OBJECTIVE: Poor metabolic health and unhealthy lifestyle factors have been associated with risk and severity of COVID-19, but data for diet are lacking. We aimed to investigate the association of diet quality with risk and severity of COVID-19 and its interaction with socioeconomic deprivation. DESIGN: We used data from 592 571 participants of the smartphone-based COVID-19 Symptom Study. Diet info

Abstract: Quantum coherence plays a fundamental role in the study and control of ultrafast dynamics in matter. In the case of photoionization, entanglement of the photoelectron with the ion is a well-known source of decoherence when only one of the particles is measured. Here, we investigate decoherence due to entanglement of the radial and angular degrees of freedom of the photoelectron. We study

Purpose: The purpose of this study was to describe experiences of working as a paid part-time firefighter (PTF) in Swedish rural areas. Design/methodology/approach: An inductive explorative design was used, based on interviews with 18 paid PTFs in Sweden. Data were analyzed using qualitative latent content analysis. Findings: Three themes emerged from the interviews and describe paid PTFs’ experie

We present a statistical mechanics theory of rubber-like elasticity in swollen and unswollen polymer networks characterized by explicitly non-Gaussian distribution functions (Laplace's, Cauchy's, and continuous Poisson's in the exponential limit). An important outcome is the derivation of new families of statistical and mechanical laws, including a discussion of energy functions of strain invarian

To celebrate its centenary year, Journal of Experimental Biology (JEB) commissioned a collection of articles examining the past, present and future of experimental biology. This Commentary closes the collection by considering the important research opportunities and challenges that await us in the future. We expect that researchers will harness the power of technological advances, such as '-omics'

This is the software artifact for the paper "Efficient Demand Evaluation of Fixed-Point Attributes Using Static Analysis" published in SLE 2024.This artifact supports the evaluation of a new demand-driven algorithm for efficient circular Reference Attribute Grammar evaluation, specifically designed to improve performance of higly circular applications, e.g., dataflow analyses for Java. The artifac

BACKGROUND: Sustained intrauterine hypoxia causes some four million perinatal deaths annually worldwide. The condition is predicated by neonatal acidemia, as determined by pH in umbilical cord blood at birth. We aimed to evaluate the association between umbilical cord arterial pH and long-term outcomes up to 20 years of follow-up.STUDY DESIGN: Using a retrospective cohort design, umbilical cord ar

We review the petrochemical industry from a joint macro, credit specialist and climate mitigation perspective. The sector carries clear relevance for bond investors, with many of the biggest petrochemical producers also being large debt issuers and being actively traded in credit portfolios. Out of the top 30 global petrochemical producers, 20 are actively traded in hard currency bond markets, and

Introduction. The introduction of publicly available large language models (LLMs) since 2022 has significantly challenged traditional library and information studies (LIS) core concepts. This paper argues that LIS needs to rethink aspects of its conceptual framework to address the challenges posed by the proliferation of AI-generated content and how this content is produced.Analysis. The study emp

Composition is a practice of key importance in software engineering. When real-time applications are composed it is necessary that their timing properties (such as meeting the deadlines) are guaranteed. The composition is performed by establishing an interface between the application and the physical platform. Such an interface does typically contain information about the amount of computing capac

The global location of R & D labs by MNCs is a rather new phenomenon; especially when it comes to establishing R & D labs in developing countries. The existing and rather limited literature on globalisation of innovation provides four possible explanations of why multinationals locate R & D labs in developing countries: reduce research costs, access large markets, tap into a large pool

Many medical schools and faculties are actively promoting scholarly inquiry into teaching and learning to improve education. The Faculty of Medicine at Lund University, Sweden, has developed a Teaching Academy with criteria for membership founded in Scholarship of Teaching and Learning (SoTL). Furthermore, the Faculty arranges a conference in medical education and also organises courses to support

Net Zero Energy Buildings, Net ZEBs, is one of many necessary measures for climate change mitigation as they may reduce the energy consumption in the building sector. The Net ZEB interacts with a grid infrastructure. It is therefore important to consider the interaction with the grid in the design phase. This paper reports an evaluation of a proposed design of a Net ZEB in the south of Sweden eva

This report makes recommendations for standardized techniques of data gathering and collection regarding: 1) skin involvement 2) joint and tendon involvement, and 3) involvement of the skeletal muscles. The recommendations in this report derive from a critical review of the available literature and group discussion. Committee recommendations are considered appropriate for descriptive clinical inve

During the Last Glacial Maximum (LGM), ice thickened considerably and expanded toward the outer continental shelf around the Antarctic Peninsula. Deglaciation occurred between >14 ka BP and ca. 6 ka BP, when interglacial climate was established in the region. Deglaciation of some local sites was as recent as 4-3 ka BP. After a climate optimum, peaking ca. 4-3 ka BP, a distinct climate cooling occu