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Over the past two decades there has been increased interest in orphan drug development for rare diseases. However, hurdles to clinical trial design for these disorders remain. This phase 1a/1b study addressed several challenges, while evaluating the safety and tolerability of the novel oral molecule KL1333 in healthy volunteers and subjects with primary mitochondrial disease.KL1333 aims to normali

The addition of environmentally friendly items to conventional items sometimes leads people to believe that the carbon footprint of the entire set decreases rather than increases. This negative footprint illusion is supposedly underpinned by an averaging bias: people base environmental impact estimates not on the total impact of items but on their average. Here, we found that the illusion’s magnit

BACKGROUND: Knee osteoarthritis (OA) is a major public health issue causing chronic pain, impaired physical function, and reduced quality of life. As there is no cure, self-management of symptoms via exercise is recommended by all current international clinical guidelines. This review updates one published in 2015.OBJECTIVES: We aimed to assess the effects of land-based exercise for people with kn

Past results suggest that fear extinction and the return of extinguished fear are compromised in adolescents. However, findings have been inconclusive as there is a lack of fear extinction and extinction retention studies including children, adolescents and adults. In the present study, 36 children (6–9 years), 40 adolescents (13–17 years) and 44 adults (30–40 years), underwent a two-day fear cond

In analyses of affordances and opportunities in different neighbourhoods it is found that access to public buildings and a well-functioning public space are of outmost importance. This is found to be especially important in neighbourhoods having a population with fewer resources, areas often discussed in terms as ‘deprived’ or ‘excluded’, concepts that alludes to the phenomenon of segregation. Pre

Purpose: The purpose of this study was to describe experiences of working as a paid part-time firefighter (PTF) in Swedish rural areas. Design/methodology/approach: An inductive explorative design was used, based on interviews with 18 paid PTFs in Sweden. Data were analyzed using qualitative latent content analysis. Findings: Three themes emerged from the interviews and describe paid PTFs’ experie

Introduction: Strengthening Primary Health Care (PHC) is essential for building resilient and equitable health systems, but PHC faces barriers in implementation, resource allocation, and political prioritisation. This study aimed to develop a strategic roadmap to enhance PHC by identifying core values, priorities, and actionable strategies through expert consensus. Methods: A two-round Delphi stud

Fibril-reinforced poroviscoelastic material models are considered state-of-the-art in modeling articular cartilage biomechanics. Yet, cartilage material parameters are often based on bovine tissue properties in computational knee joint models, although bovine properties are distinctly different from those of humans. Thus, we aimed to investigate how cartilage mechanical responses are affected in t

We review the petrochemical industry from a joint macro, credit specialist and climate mitigation perspective. The sector carries clear relevance for bond investors, with many of the biggest petrochemical producers also being large debt issuers and being actively traded in credit portfolios. Out of the top 30 global petrochemical producers, 20 are actively traded in hard currency bond markets, and

This thesis covers a set of methods related to machine perception and localization, which are two important building blocks of artificial intelligence. In Paper I, we explore the concept of regression via classification (RvC), which is often used for perception tasks where the target variable is either ordinal or when the distance metric of the target space is not well-suited as an objective funct

Internet-of-Things (IoT) systems consist of spatially distributed interacting devices. In contrast to desktop applications, IoT systems are always running and need to deal with unresponsive devices and weak connectivity. In this thesis, we propose techniques for simplifying the development of such systems. The work addresses IoT systems organised as reusable services connected by compositions. We

Purpose: The goal of this study was to determine the degree of consensus in the management of spinal cord tethering (TC) in patients with anorectal malformation (ARM) in a large cohort of European pediatric centers. Methods: A survey was sent to pediatric surgeons (one per center) members of the ARM-Net Consortium. Results: Twenty-four (86%) from ten different countries completed the survey. Overa

Why do some foreign ministers stay longer in office than others? Are they punished when the country loses a war? Several scholars have focused on the tenure of leaders as an important predictor of foreign policy outcomes, such as war onset, creating an interest in leadership survival. We here shift the focus to the survival of other important politicians in cabinet-foreign ministers, hypothesizing

The ‘planetary boundaries’ framework identifies Earth system processes that contribute to the stability and resilience of the planet (Rockström et al., 2009a), setting out the limits to changes the Earth can support for remaining in a Holocene-like state. A key question for global sustainable development that emerges from this framework is how to secure social equity while respecting planetary bou

The aim is to test the reliability of two alcohol screening instruments: (1) The Parent Alcohol Screening Questionnaire (PASQ5), and (2) the Social Support for an Alcohol-free Pregnancy (SSAFP) questionnaire. This is a cohort study from the south of Sweden using repeated surveys during pregnancy. To examine if responses differed according to different data collection methods, two cohorts consistin

Two experiments involving an international collaboration ofexperimenters sought to replicate and extend a previously publishedpsi experiment on precognition by Daryl Bem that has been the focusof extensive research. The experiment reverses the usual cause–e! ectsequence of a standard psychology experiment using priming and reactiontimes. The preregistered con" rmatory hypothesis is that response t

Informal carers in paid work are known as working carers (WKCs). This combination of care and work is particular to them, and their support needs may differ from other informal carers. This exploratory study describes the caregiving-related factors associated with experiencing caregiving as demanding and a decreased ability to work in WKCs. The Swedish National Carer Survey was conducted in a stra

The Internet, apart from being a fascinating field of study in its own right, has opened up new possibilities for scholars to get news, gather data, connect with informants, and in general stay updated on rapidly changing developments in Chinese society. Social media have added yet another dimension as it enables researchers to catch up with events and public debates as they unfold and get valuabl

Local delivery of amyloid beta oligomers from the tip of a nanopipette, controlled over the cell surface, has been used to deliver physiological picomolar oligomer concentrations to primary astrocytes or neurons. Calcium influx was observed when as few as 2000 oligomers were delivered to the cell surface. When the dosing of oligomers was stopped the intracellular calcium returned to basal levels o