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Background: A unique feature of alveolar mast cells is their low high-affinity IgE receptor (FcεRI) expression. Recent discoveries in uncontrolled asthma suggest that the appearance of FcεRI-expressing alveolar mast cells may be a novel disease-specific feature of allergic asthma. This study investigates whether increased FcεRI-expressing alveolar mast cells are present in patients with mild aller

Schema för KURSNAMN 10 p (15 ECTS) HT -1 2002 1 Schedule for GEON05 Quaternary geology, 15 hp (15 ECTS credits) fall, Fall semester 1, 2016 GEON05: Glacial sedimentology: processes, sediments and land systems Course leader: Per Möller Teachers: PM = Per Möller; JA = Johanna Anjar; MB = Martin Bernhardson; CG = Carl Regnéll E-mail address; per.moller@geol.lu.se ; johanna.anjar@geol.lu.se; martin.be

https://www.geology.lu.se/sites/geology.lu.se/files/geon05_schema_8aug2016.pdf - 2026-04-23

Name 1 MDC CV HOMA 2023-09-26 Contents: Data from the HOMA-study and its subcohorts.The aim was to study the relationship between disturbed glucose metabolism and 24-hour ECG as well as changes in IMT/plaque in carotid artery ultrasound. # lines and # variables: MDC_CV_1114.sav # lines 1114 # variables 3 MDC_CV_HOMA.sav # lines 909 # variables 72 MDC_CV_HOMA_Diet_Physact.sav # lines 391 # variable

https://www.malmo-kohorter.lu.se/sites/malmo-kohorter.lu.se/files/2023-11/MDC%20CV%20HOMA.pdf - 2026-04-23

Lymphocytes from human peripheral blood were separated by Countercurrent distribution (CCD) in a charged aqueous two-phase system composed of Dextran T 500 and polyethylene glycol 6000. Maximal responses to the T-cell mitogens phytohemagglutinin and concanavalin A were detected in a part of the distribution corresponding to the area where the highest percentage of E rosetting cells were seen. Anti

Regular prophylactic treatment with factor VIII (FVIII) and factor IX (FIX) concentrates in hemophilia A and B, respectively, is introduced in early infancy and has resulted in dramatic improvement of the conditions. Recombinant FVIII and FIX concentrates have been available for > 25 years and have been modified and refined through the years; however, unfortunately frequent intravenous administrat

Protein ADP-ribosylation is a reversible post-translational modification that regulates important cellular functions. The identification of modified proteins has proven challenging and has mainly been achieved via enrichment methodologies. Random mutagenesis was used here to develop an engineered Af1521 ADP-ribose binding macro domain protein with 1000-fold increased affinity towards ADP-ribose. T

We have characterized 2 distinct mechanisms through which infectious agents may promote platelet adhesion and thrombus formation in flowing blood, thus contributing to the progression of disease. In one case, the process initiates when the integrin alpha(IIb)beta(3) mediates platelet arrest onto immobilized bacterial constituents that have bound plasma fibrinogen. If blood contains antibodies agai

EndoS from Streptococcus pyogenes efficiently hydrolyzes the functionally important and conserved N-linked glycan of IgG in human blood. Repeated i.v. administration of EndoS in rabbits completely hydrolyzes the glycans of the whole IgG pool, despite the generation of anti-EndoS antibodies. EndoS administration had no apparent effects on the health of the animals. EndoS hydrolysis of the IgG glyca

Group B Streptococcus (GBS) is a leading cause of invasive bacterial infections in human newborns. A key GBS virulence factor is its capsular polysaccharide (CPS), displaying terminal sialic acid (Sia) residues which block deposition and activation of complement on the bacterial surface. We recently demonstrated that GBS Sia can bind human CD33-related Sia-recognizing immunoglobulin (Ig) superfami

Background: A significant proportion of patients with asthma have persistent symptoms despite treatment with inhaled glucocorticosteroids. Objective: We hypothesized that in these patients, the alveolar parenchyma is subjected to mast cell-associated alterations. Methods: Bronchial and transbronchial biopsies from healthy controls (n = 8), patients with allergic rhinitis (n = 8), and patients with

Popular Abstract in Swedish Komplementsystemet utgör en del av den medfödda immuniteten och är viktigt i försvaret mot angripande mikroorganismer. Ärftlig C2-brist (C2D) är en av de vanligaste bristerna inom komplementsystemet och förekommer i en frekvens av 1: 20 000 hos personer med västerländsk härstamning. I de aktuella undersökningarna har mer än 40 personer med C2D identifierats och observerThe complement system is a part of the innate immunity and is essential in the defence against microorganisms. Hereditary C2 deficiency (C2D) is one of the most common complement deficiency states with an estimated prevalence of 1:20,000 in persons of Western descent. In the present investigation, the identification of more than 40 C2D persons at a single centre combined with long observation peri

A new type of continuous, supermacroporous, monolithic, cryogel affinity adsorbent was developed, allowing specific fractionation and separation of human peripheral blood lymphocytes in a chromatographic format. The affinity adsorbent was used to design a novel cell separation strategy, which was based on the interaction of protein A from Staphylococcus aureus with cells bearing IgG antibodies on

In this paper, the authors show that liquid-liquid partition chromatography in an aqueous two-phase system offers unique possibilities of comparing the overall surface properties of intact antibodies in solution before and after binding of antigen. The authors demonstrate that the surface properties of antigen-antibody complexes are dependent on the variable regions of the antibodies, the nature o

Angiogenesis is a hallmark of cancer and is now a validated therapeutic target in the clinical setting. Despite the initial success, anti-angiogenic compounds impinging on the vascular endothelial growth factor (VEGF) pathway display limited survival benefits in patients and resistance often develops due to activation of alternative pathways. Thus, finding and validating new targets is highly warr

Schema för KURSNAMN 10 p (15 ECTS) HT -1 2002 1 Schedule for GEON05 Quaternary geology, 15 hp (15 ECTS credits) fall, Fall semester 1, 2016 GEON05: Glacial sedimentology: processes, sediments and land systems Course leader: Per Möller Teachers: PM = Per Möller; JA = Johanna Anjar; MB = Martin Bernhardson; xx = xxxxxx E-mail address; per.moller@geol.lu.se ; johanna.anjar@geol.lu.se; martin.bernhard

https://www.geology.lu.se/sites/geology.lu.se/files/geon05_schema_20160930.pdf - 2026-04-23