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Moraxella catarrhalis is a human-specific commensal of the respiratory tract and an opportunistic pathogen. It is one of the leading cause of otitis media in children and of acute exacerbations in patients with chronic obstructive pulmonary disease, resulting in significant morbidity and economic burden. Vaccines and new immunotherapeutic strategies to treat this emerging pathogen are needed. Comp
Streptococcus pyogenes is an exclusively human pathogen that can provoke mild skin and throat infections but can also cause fatal septicemia. This gram-positive bacterium has developed several strategies to evade the human immune system, enabling S. pyogenes to survive in the host. These strategies include recruiting several human plasma proteins, such as the complement inhibitor, C4b-binding prot
Bone morphogenetic proteins (BMPs) are expressed and secreted during fracture repair. Although they are likely to be required for this process, little is known about their physiological role in bone regeneration. Noggin is a protein that specifically binds and inactivates several BMPs, It plays fundamental roles during early embryonal development and limb morphogenesis by this BMP-inactivating act
Although carbonate-carbon (C), an integral part of biochar-C, contributes to the liming properties of that material, it also interferes with the estimation of the stable organic C fraction in biochars. In this study, four methods were compared in order to quantify the carbonate-C in biochars: two direct (a titrimetric procedure and thermogravimetric analysis, TGA), and two indirect (acid treatment
Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related mortality and can occur with any type of transfusion. TRALI is thought to be primarily mediated by donor antibodies activating recipient neutrophils resulting in pulmonary endothelial damage. Nonetheless, details regarding the interactions between donor antibodies and recipient factors are unknown. A murine a
IntroductionSlow sand filtration is an established method for drinking water treatment, however, the knowledge about their microbial ecology remains limited. Maintenance of slow sand filters (SSF) includes washing to remove biofilm growth in the sand and restore flow through the filter. Understanding how this impacts produced water is important as the SSF may influence the bacterial flora in the f
Stora förändringar och varierad elproduktion har lett till många osäkerheter i elsystemets marknader. Balanseringsverktygen har därmed hamnat i rampljuset med stor inkomstpotential idag och möjligen även långt framöver. Denna rapport visar att det finns stora möjligheter för vätgassystem och batterier att medverka på dessa marknader. En förväntad fördubbling av elproduktion under de kommande 20 årIn order to move away from fossil fuels many governments and industries are focusing their new investments in electricity and alternative fuels such as green hydrogen from electrolyzers using renewable electricity. High investment costs and electricity costs are a hindrance for the future development of a hydrogen economy which can utilize an increasing intermittent power generation. The aim of th
Föreliggande undersökning syftar till att utvärdera möjligheten att använda bioimpedansspektrometri för att mäta tumör- och vävnadsrespons på strålterapi. Bioimpedansmätningar utförda med CythorLab ™ utrustade med en signalgenerator med en känd högutgångsimpedans och signalmätanordning som kan mäta spänningen som appliceras av generatorn. Styrenheten utlöser signalgeneratorn som genererar en MLS-sThe present investigation aims to evaluate the possibility of using bio-impedance spectrometry to measure tumour and tissue response to radiation therapy. Bio -impedance measurements performed with CythorLab™ equipped with a signal generator with a known high output impedance and signal measuring device able to measure the voltage applied by the generator. The control unit triggers the signal gene
Patients with chronic liver impairment often display symptoms of affective psychiatric nature where the choice for antidepressant treatment is rational. Since caution is recommended when these drugs are used in such patients, a dose reduction is usually performed. We have previously reported that a dose reduction to liver-impaired portacaval shunted rats has resulted in similar brain concentration
Popular Abstract in Swedish När en familjemedlem drabbas av en demenssjukdom påverkas även de övriga familjemedlemmarna på något sätt. Allt mer vård och omsorg flyttar in i hemmen och de närståendes roll och funktion blir mycket centrala. Syftet med denna doktorsavhandling var att undersöka hur närstående till demenssjuka personer mår, och att planera, genomföra och undersöka effekten av en 5-vec
The increased interest in predatory bacteria due to their ability to kill antibiotic resistant bacteria has also highlighted their inherent plethora of hydrolytic enzymes, and their potential as natural sources of novel therapeutic agents and biotechnological tools. Here, we have identified and characterized a novel protease from the predatory bacterium Bdellovibrio bacteriovorus: BspE (Bdellovibr
Lägg till titel FÖRSÄTTSSIDA STYRDOKUMENT Kvalitetspolicy för Lunds universitet Typ av styrdokument: Policy Definition av typen av styrdokument: En policy uttrycker ledningens övergripande viljeriktning eller värden som ska beaktas inom det område policyn omfattar och sätter ramarna för ett visst handlande och utgör en stark rekommendation om ett visst handlingssätt. Beslutsfattare: Universitetsst
Lägg till titel FÖRSÄTTSSIDA STYRDOKUMENT Kvalitetspolicy för Lunds universitet Typ av styrdokument: Policy Definition av typen av styrdokument: En policy uttrycker ledningens övergripande viljeriktning eller värden som ska beaktas inom det område policyn omfattar och sätter ramarna för ett visst handlande och utgör en stark rekommendation om ett visst handlingssätt. Beslutsfattare: Universitetsst
