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Efficacy of T-cell assays for the diagnosis of primary defects in cytotoxic lymphocyte exocytosis

Primary hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder associated with autosomal recessive variants in genes required for perforin-mediated lymphocyte cytotoxicity. A rapid diagnosis is crucial for successful treatment. Although defective cytotoxic T lymphocyte (CTL) function causes pathogenesis, quantification of natural killer (NK)–cell exocytosis triggered by K562 targe

Streptococcus pyogenes secreted enzymes interacting with the human host

Streptococcus pyogenes is one of the most common bacteria infecting humans. One of the factors contributing to the disease-causing properties is the secreted streptococcal cysteine proteinase, SpeB, which degrades several host proteins in connective tissue and circulation. SpeB activity depends on the transformation from an inactive precursor, zymogen, into a mature proteinase. We show that

Results of a phase I/II study of ocrelizumab, a fully humanized anti-CD20 mAb, in patients with relapsed/refractory follicular lymphoma

Background: Ocrelizumab is a humanized anti-CD20 antibody with increased antibody-dependent cellular cytotoxicity compared with rituximab. This phase I/II study evaluated its safety and efficacy in patients with relapsed/refractory follicular lymphoma (FL) after prior rituximab therapy. Design and methods: Forty-seven patients were treated in three dose cohorts and received eight infusions every 3

Creep Recovery and Elastic Modulus of High Performance Concrete

This article outlines an experimental and numerical study on short-term and long-term creep recovery in High Performance Concrete. About 200 cylinders and 800 cubes were tested. The ambient climate was held constant at 20 °C and 55% relative humidity. Results and analyses are presented as regards short-term and long-term creep recovery with some related properties. The creep deformations are separ

Development and validation of a novel Simoa assay for NPTX2 in Alzheimer's disease and Down syndrome

INTRODUCTION: Synaptic dysfunction and loss are pathological hallmarks of neurodegenerative diseases. Neuronal pentraxin 2 (NPTX2), a presynaptic protein involved in synaptic plasticity, has been linked to cognitive decline in Alzheimer's disease (AD) and other neurodegenerative disorders. METHODS: We developed and validated a novel single molecule array (Simoa) for NPTX2 in cerebrospinal fluid, w

Potentialities of manganese ore and iron-carbon particles for pharmaceuticals and personal care products removal in electroactive constructed wetland

This study explores the use of manganese ore, iron-carbon particles (Fe-C), and gravel as anode fillers in electroactive constructed wetlands (ECWs) to treat wastewater containing pharmaceuticals and personal care products (PPCPs) including ciprofloxacin (CIP), ofloxacin (OFL), and naproxen (NPX), while also assessing bioelectricity production. Although the presence of PPCPs reduced pollutant remo

LL SMMM24 eng VT25 241113 uppdering doi 260420

LL_SMMM24_eng_VT25_241113_uppdering_doi Reading list for Retail Development and Places (SMMM24), 7,5 credits. The reading list was approved by the Board of the Department of Service Studies 2024-11-13. The reading list is valid from 2024-11-13. Aslan, Devrim. Umut. (2025). Learning from an Adaptive Resilient Local Street: Ensuring Town Centre Vibrancy through Diverse Modes of Shopping. Cities. Doi

https://www.ses.lu.se/en/sites/ses.lu.se.en/files/2026-04/LL_SMMM24_eng_VT25_241113_uppdering_doi_260420.pdf - 2026-05-29

LL SMMM24 eng VT25 241113

LL_SMMM24_eng_VT25_241113 Reading list for Retail Development and Places (SMMM24), 7,5 credits. The reading list was approved by the Board of the Department of Service Studies 2024-11-13. The reading list is valid from 2024-11-13. Aslan, Devrim. Umut. (Forthcomming). Learning from an Adaptive Resilient Local Street: Ensuring Town Centre Vibrancy through Diverse Modes of Shopping. Cities. Davies, A

https://www.ses.lu.se/en/sites/ses.lu.se.en/files/2024-11/LL_SMMM24_eng_VT25_241113.pdf - 2026-05-29

Tuning the Electronics of Bis(tridentate)ruthenium(II) Complexes with Long-Lived Excited States: Modifications to the Ligand Skeleton beyond Classical Electron Donor or Electron Withdrawing Group Decorations

A series of homoleptic bis(tridentate) [Ru-(L)(2)](2+) (1, 3) and heteroleptic [Ru(L)(dqp)](2+) complexes (2, 4) [L = dqxp (1, 2) or dNinp (3, 4); dqxp = 2,6-di(quinoxalin-5-yl)pyridine, dNinp = 2,6-di(N-7-azaindol-1-yl)pyridine, dqp = 2,6-di(quinolin-8-yl)pyridine) was prepared and in the case of 2 and 4 structurally characterized. The presence of dqxp and dNinp in 1-4 result in anodically shifte

Navigating the Shift from B2C to D2C: Addressing Marketing Strategy Challenges for Credit Reference Agencies in Sweden

Detta examensarbete undersöker hur ett business-to-business (B2B) inriktat företag som utvecklar ett direct-to-consumer (D2C) segment bör anpassa sin marknadsföringsstrategi för att växa genom marknadspenetration. Författarna har undersökt ett svensk kreditupplysningsföretag, Upplysningscentralen (UC), som har expanderat sin verksamhet till konsumentmarknaderna för kreditinformationstjänster och i

Large-Eddy Simulation of Supersonic Combustion in a Mach 2 Cavity Model Scramjet Combustor

In this study, we report on reactive large-eddy simulations (LESs) of flow and combustion in the U.S. Air Force Research Laboratory Research Cell 19 cavity-based scramjet combustor. This case involves the combustion of ethylene that is injected into a cavity. It has previously been studied experimentally with multiple techniques, including particle image velocimetry, hyperspectral imagining, and l

Utvc21 schedule autumn2017 updated 2018-08-08

BIDS UTVC21 Lectures and seminars 2017 (Updated 2017-08-08) Date Time Room Theme Activity Group Lecturer 30/8 10-12 Världen Meet Your Programme Coordinator Lec 1/1 AF 30/8 13-15 Världen Course Introduction Lec 1/1 TAX 1/9 10-12 Världen Introduction: questioning development Potter Ch. 1; Allen et al Ch. 1-2 Lec 1/1 YM 1/9 13-15 Världen Introduction: history and development Allen Ch. 1; Allen et al

https://www.keg.lu.se/sites/keg.lu.se/files/utvc21_schedule_autumn2017_updated_2018-08-08.pdf - 2026-05-30

Utvc21 ht 2017 schedule 2017-05-04tb

BIDS UTVC21 Lectures and seminars 2017 (Updated 2016-04-06) Date Time Room Theme Activity Group Lecturer 30/8 10-12 Världen Meet Your Programme Coordinator Lec 1/1 AF 30/8 13-15 Världen Registration and Introduction Lec 1/1 TAX 1/9 10-12 Världen Introduction: questioning development Potter Ch. 1; Allen et al Ch. 1-2 Lec 1/1 YM 1/9 13-15 Världen Introduction: history and development Allen Ch. 1; Al

https://www.keg.lu.se/sites/keg.lu.se/files/utvc21_ht_2017_schedule_2017-05-04tb.pdf - 2026-05-30