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Introduction Neoadjuvant therapy is the standard of care for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC). Studies on first-generation antibody-drug conjugates, such as trastuzumab emtansine (T-DM1), showed equal or slightly lower efficacy than chemotherapy combined with dual HER2 blockade. Trastuzumab deruxtecan (T-DXd) is a next-generation conjugat
Firms require multi-stakeholder ecosystems to successfully create and implement circular business models for electric vehicle (EV) battery second life. However, there is a notable absence of guiding instruments to assist EV battery ecosystem actors in formulating and managing strategies for battery second-life operations. This study's aim is to analyze how circular ecosystems are formed and manage
Background: Expanding access to self-management via Digital Health Technologies may supplement traditional care, mitigating pressures on primary care through self-management. Primary Care Physicians (PCP) can play a critical role in the integration of digital health technologies into patient care, but it is unclear what factors influence PCPs’ recommendation of such technologies. Aims: To identify
BACKGROUND AND OBJECTIVE: Bacillus Calmette-Guérin (BCG) reduces disease recurrence and progression in intermediate- and high-risk non-muscle-invasive bladder cancer (NMIBC). BCG-associated adverse events during instillations are common, leading to treatment cessation. Prophylactic use of quinolones in conjunction with BCG instillations is one approach for reducing BCG-associated adverse events. O
Chapter 3 examines the techniques and elements of paramilitarism through the intersections of both domestic and foreign policy. By focusing on extralegal activities as a derivative of state violence, the interactions between domestic and foreign policy and the continuities of unconventional warfare are analyzed. Specifically, it explores how Turkey has acquired and transformed modern forms of unco
Emerging from the citizen movements of the early 2010s, New Municipalism merges the administrative capacity of municipal government with the organizational capacities of activists and social movements to build more equal, just and ecological local economies. In these contexts, Digital Municipal Currencies (DMCs) emerge as potent instruments of counter-hegemonic struggle, enabling cities to impleme
BACKGROUND: This systematic review and meta-analysis aimed to assess the diagnostic test accuracy of blood-based biomarkers (BBMs) for detecting Alzheimer's disease (AD) pathology in cognitively impaired individuals in specialized care settings. The overarching goal is to inform the development of a clinical practice guideline, led by the Alzheimer's Association, for use in clinical practice. METH
Endovascular therapy (EVT) has proven benefit for patients with anterior circulation large vessel occlusion (LVO) strokes with moderate-to-severe deficits, but its value in patients presenting 6-24 hours after onset with mild symptoms (NIH Stroke Scale score ≤5) remains unclear. This journal club article examines a retrospective analysis of CLEAR registry data comparing EVT with medical management
Hyperfine structure measurements have been performed in some neutron-deficient gold isotopes, using on-line atomic-beam magnetic resonance (ABMR) techniques at the ISOLDE facility, CERN. The following results have been obtained: 185Au, I = 5/2; 187Au, Δv = 44.35(60) GHz, μ = 0.72(7) n.m. and 188Au, Δv = ± 2992(30) MHz. A discussion of the influence of the hyperfine anomaly is included. With due re
Numerical models of meteorite delivery from impacts on the Moon have demonstrated that the impact event forming the lunar crater Tycho (~85 km diameter; ca. 109 Ma age) would have delivered considerable amounts of ejected material to Earth. The ejecta, containing lunar Ti- and V-rich chrome spinels, would have been distributed globally and admixed with seafloor sediments over a few meters of a typ
The role of education for school-aged refugee children has evolved throughout history, influenced by time, geopolitical contexts, public perceptions, and ideas about the purposes of education. This article examines refugee education in Finland and Sweden over the past century, focusing on three periods. The first is the 1920s, when newly independent Finland agreed to the migration of large groups
Background: Interventions in the form of animal-assisted and nature-based activities are promising for young adults with autism, but there is a knowledge gap concerning the long-term values of these. Aim: The aim was to describe the activity levels in daily life and socioeconomic aspects for young adults with autism one year after a 12-week intervention with animal-assisted and nature-based activi
Aim: To provide an overview of a project aimed at enhancing person-centred surgical care through teamwork and professional development. Design: A discursive paper with the purpose of describing and discussing the project activities to strengthen person-centred care, teamwork and professional development. Methods: This project aimed to strengthen evidence-based surgical nursing care within a Surger
Background: Myocardial infarction with non-obstructive coronary arteries (MINOCA) demands prompt mechanistic clarification. Early integration of coronary CT angiography (CCTA) and cardiovascular magnetic resonance (CMR) can refine diagnosis during the acute phase. Methods: Twenty-one consecutive patients (41 ± 10 years; 71% men) presenting with troponin-positive chest pain and unobstructed coronar
Background: Disengagement from outdoor recreation may diminish the positive benefits on health and well-beingin old age. The purpose of this study is to present a contextual, theoretical, and empirical rationale for anintervention, aiming to promote continued engagement in outdoor recreation for older adults in a Swedishcontext.Methods: The paper includes a contextualization of outdoor recreation
In this paper, we outline the need for a coordinated international effort toward the building of an open-access Global Ocean Oxygen Database and ATlas (GO2DAT) complying with the FAIR principles (Findable, Accessible, Interoperable, and Reusable). GO2DAT will combine data from the coastal and open ocean, as measured by the chemical Winkler titration method or by sensors (e.g., optodes, electrodes)
In KEYNOTE-564, adjuvant pembrolizumab, a PD-1 antibody, significantly improved disease-free survival (DFS) in localised clear-cell renal cell carcinoma (ccRCC) with a high risk of relapse. In 2021, the European Association of Urology RCC Guidelines Panel issued a weak recommendation for adjuvant pembrolizumab for high-risk ccRCC as defined by the trial until final overall survival data and result
High levels of cell-free haemoglobin (Hb) may occur in plasma as a consequence of e.g., pathological haemolysis or blood transfusion. These Hb molecules can be removed from blood circulation by forming a complex with the acute-phase protein haptoglobin (Hp) and thereby can also the intrinsic toxicity of free Hb be limited. In this study it is shown that ferric HbA, HbF, HbE and HbS, respectively,
