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Philadelphia (Ph) chromosome-positive leukemia is characterized by the BCR/ABL1 fusion protein that affects a wide range of signal transduction pathways. The knowledge about its downstream target genes is, however, still quite limited. To identify novel BCR/ABL1-regulated genes we used global gene expression profiling of several Ph-positive and Ph-negative cell lines treated with imatinib. Followi

Popular Abstract in Swedish Bröstcancer är den vanligaste cancerformen hos kvinnor världen över och den står för omkring 30% av all cancer hos kvinnor i Sverige. Varje år får ca 7000 kvinnor i Sverige diagnosen och man räknar att ca en av tio kvinnor insjuknar under sin livstid. Trots att så många får bröstcancer så är det betydligt färre kvinnor som dör av bröstcancer; för närvarande ca 1500 per The aim of this thesis was to study reproductive factors and genetic polymorphisms in relation to breast cancer risk and survival. An important component of this was to investigate the risk of specific breast cancer subgroups. The association between parity and breast cancer-specific survival was studied among 4,453 women diagnosed with breast cancer in Malmö, Sweden. It was found that: • Nullipar

Popular Abstract in English The present thesis investigates ways in which motion is described in Xenophon’s Anabasis, written in the 2nd part of the third century BC. The Anabasis tells the story of the Ten Thousand – the Greek soldiers who marched from Sardis to Babylon, and from there back to the Greek coast of the Black Sea – covering a great variety of motion events. The study examines passageThe thesis compares different prepositions and verbal prefixes denoting direction in Ancient Greek. The corpus covers passages in Xenophon’s Anabasis where such directional elements are used. In this work, it has been examined how the usage of prepositions differs from that of prefixes when they denote a concrete motion in space, what reasons lie behind their usage, and how various directional ele

Popular Abstract in Swedish Inledning För att kunna sätta in resurser där de behövs bäst, finns det en önskan att kunna förutsäga vilka graviditeter som kommer att bli komplicerade. Vid preeklampsi (havandeskapsförgiftning), tillväxthämning hos fostret samt blodproppssjukdom finns det idag inget säkert sätt att tidigt i graviditeten veta vilka som kommer att drabbas. Denna oförmåga att kunna föruThe aim of this thesis was to improve background knowledge for making a reliable medical evaluation at the first visit of a woman in her 13th gestational week, to the antenatal clinic. We have focused on the prediction and the risk estimation of preeclampsia, intra-uterine growth restriction (IUGR), and thrombosis. The thesis was based on five studies, in which we have evaluated biochemical analy

Popular Abstract in Swedish Vad händer när en halvledarkristall blir väldigt liten? Ett halvledarmaterials optiska och elektriska egenskaper hänger ihop med hur partiklarna som bär elektrisk laddning, elektroner och hål, uppför sig. (En elektron är en negativt laddad partikel. Ett hål kan beskrivas som en positivt laddad bubbla i ett hav av elektroner, och precis som med bubblor är det ibland enklQuantum dots (QDs) are semiconductor nanocrystals with quantum confinement. This thesis uses various time-resolved spectroscopic techniques to study ultrafast charge carrier dynamics in colloidal CdSe quantum dots that are important both from a theoretical point of view and for their relevance for solar cell applications. Using 2D electronic spectroscopy, we follow charge carrier relaxation and tr

Popular Abstract in Swedish Att en temperaturskillnad kan ge upphov till en elektrisk ström upptäcktes redan på 1800-talet och fenomenet är känt som den termoelektriska effekten. Denna effekt skulle kunna effektivisera energianvändningen överallt där det går att utnyttja en temperaturskillnad. Ett exempel är i en bil där en stor del av energin som tillförs genom bränsle förloras som spillvärme. OmThermoelectricity is being intensively researched as it is believed to hold great promise for applications in power generation and cooling. One way to quantify the electrical power output of a thermoelectric material is the power factor, a function of electrical conductivity and thermopower. There are relationships between these relevant material properties that make efficient thermoelectric mater

Popular Abstract in Swedish Bakgrund: Ischemisk hjärtsjukdom (IHS) och slaganfall är de främsta orsakerna till morbiditet och mortalitet i västvärlden och är ett stort hälsoproblem för samhället. Kardiovaskulära läkemedel används med syfte att förebygga (t. ex. blodtryckssänkande läkemedel och lipidsänkande läkemedel) eller lindra (t. ex. nitrater) dessa sjukdomar. Den optimala effektiviteten ("efBackground: Ischaemic heart disease (IHD) and stroke are the main causes of morbidity and mortality in developed countries and hence constitute a large public health problem. Cardiovascular drugs are used in an effort to prevent (e. g. blood pressure lowering drugs (BPLD) and lipid lowering drugs) and palliate (e. g. nitrates) these disorders. The efficacy and safety of these drugs have been evalu

Popular Abstract in English Fruits are a key complement to the diet of many people in the southern region of Africa, especially in rural areas. maphilwa (Vangueria infausta L.), maçanica (Ziziphus mauritiana), maçala (Strychnos spinosa), mapsincha (Salacia kraussi), cajú (Anacardium accidentale L.), mavungwa (Landolpia kirki) are some of the most commonly found fruits in sub-Saharan Africa, particThis study concerns the identification and characterisation of volatile components of fruits, and evaluation of the effect of heat treatment and drying on retention or loss of volatiles of fruits. The investigation included developing a procedure to extract volatile components from the fruit matrix, a purification step, separation, identification and quantification. Initial experiments with Vangue

The incidence of stroke and dementia are diverging across the world, rising for those in low- and middle-income countries and falling in those in high-income countries. This suggests that whatever factors cause these trends are potentially modifiable. At the population level, neurological disorders as a group account for the largest proportion of disability-adjusted life years globally (10%). Amon

För att en utveckling ska anses hållbar måste mål ur såväl sociala, ekonomiska som miljömässiga aspekter vara uppfyllda. Det svenska miljömålssystemet, baserat på Agenda 2030, innehåller 16 miljökvalitetsmål och ett antal etappmål. För genomförande och uppföljning ansvarar åtta myndigheter, av vilka Boverket har ansvar för målet ”En god bebyggd miljö”. Faktorer som har valts att studera är inomhusFor a development to be considered sustainable, social, economic and environmental requirements must be met. The Swedish sustainable development goals, based on Agenda 2030, contain 16 national environmental quality goals. The National Board of Housing, Building and Planning is responsible for achieving the goal "A good built environment". Essential factors chosen for studies are: indoor environme

The existing information supports the use of this material as described in this safety assessment. Hexyl hexanoate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog hexyl isobutyrate (CAS # 2349-07-7) show that hexyl hexanoate is not

BACKGROUND Targeted temperature management is recommended for patients after cardiac arrest, but the supporting evidence is of low certainty. METHODS In an open-label trial with blinded assessment of outcomes, we randomly assigned 1900 adults with coma who had had an out-of-hospital cardiac arrest of presumed cardiac or unknown cause to undergo targeted hypothermia at 33°C, followed by controlled

Byggnaders energieffektivitet är ett fokusområde i arbetet med att minska klimatförändringarna, då byggnader står för cirka 40 procent av den totala energianvändningen i Europeiska unionen. En lösning som tillämpas för att minska byggnaders energibehov är att ständigt införa strängare byggregler. Följaktligen ökar betydelsen av precisa och effektiva simuleringar för att kunna beräkna byggnaders frAs most countries worldwide continue to mitigate climate change, one area of focus is a building's energy efficiency. Buildings currently account for approximately 40 per cent of the total energy use in the European Union. One solution for reducing the energy demand from buildings is by continually implementing more stringent building regulations. Consequently, the importance of accurate and effic

Background: Previous studies have indicated that vitamin K deficiency is common in non-bleeding critically ill patients with slightly prolonged prothrombin time-international normalized ratio (PT-INR). It has never been investigated thoroughly whether the administration of vitamin K to these patients could affect their PT-INR. Therefore, the aim of this registry study was to evaluate changes in PTBackground Previous studies have indicated that vitamin K deficiency is common in non-bleeding critically ill patients with slightly prolonged prothrombin time-international normalized ratio (PT-INR). It has never been investigated thoroughly whether the administration of vitamin K to these patients could affect their PT-INR. Therefore, the aim of this registry study was to evaluate changes in PT-

We review the main software and computing challenges for the Monte Carlo physics event generators used by the LHC experiments, in view of the High-Luminosity LHC (HL-LHC) physics programme. This paper has been prepared by the HEP Software Foundation (HSF) Physics Event Generator Working Group as an input to the LHCC review of HL-LHC computing, which has started in May 2020.

Popular Abstract in Swedish Denna doktorsavhandling i radiofysik (medicinsk strålningsfysik) behandlar metodutveckling för kvantifiering av intrakraniella rörelser samt för bestämning av blodflöde och blodvolym i olika vävnader. De tekniker som använts är bildgivande respektive spektroskopiska kärnspinnresonansmetoder (NMR-metoder). I klinisk miljö (diagnostisk radiologi) benämns den bildgivande uIn this project, the potential of magnetic resonance (MR) imaging and spectroscopy in studies of microcirculation and haemodynamics was evaluated. The spatial and temporal characteristics of human pulsatile brain-tissue movements in healthy individuals, relevant for the understanding of the cerebrospinal-fluid (CSF) circulation and the pathogenesis of hydrocephalus, were thoroughly investigated. A

Studies have found that depressive states in old age that do not fulfil the criteria for major depression are clinically important depressive states. These depressive states are common in primary care patients. Therefore, studies of late-life depression from a primary care perspective are needed. A depressive rating scale, Hopkins Symptom Checklist-25 (HSCL-25), was used in a community survey in 1

Popular Abstract in Swedish Populärvetenskaplig sammanfattning på svenska Denna avhandling handlar om kalretikulin (engelska: calreticulin; CRT), ett protein som bidrar till att andra protein får rätt struktur och som också är inblandat i en kvalitetskontroll av dessa. CRT ser också till att kalciumbalansen i cellen upprätthålls. Hur går detta då till och hur bidrar denna avhandling till att öka kCalreticulin (CRT) is an endoplasmic reticulum (ER)-located protein involved in quality control of newly synthesized proteins as well as in calcium homeostasis of the cell. Most of what is known about CRT arises from studies of mammalian systems. However, using a Arabidopsis thaliana CRT gene expressed in mouse fibroblasts deficient of endogenous CRT, the wild type phenotype could be rescued with