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Hypotension after cardiac arrest could aggravate prolonged hypoxic ischemic encephalopathy. The association of circulatory shock at hospital admission with outcome after cardiac arrest has not been well studied. The objective of this study was to investigate the independent association of circulatory shock at hospital admission with neurologic outcome, and to evaluate whether cardiovascular comorb

Introduction It is standard of care to provide sedation to critically ill patients to reduce anxiety, discomfort and promote tolerance of mechanical ventilation. Given that sedatives can have differing effects based on a variety of patient and pharmacological characteristics, treatment approaches are largely based on targeting the level of sedation. The benefits of differing levels of sedation mus

Background: Cardiac arrest (CA) represents the third leading cause of death worldwide. Among patients resuscitated and admitted to hospital, death and severe neurological sequelae are frequent but difficult to predict. Blood biomarkers offer clinicians the potential to improve prognostication. Previous studies suggest that circulating non-coding RNAs constitute a reservoir of novel biomarkers. The

Background: Randomised clinical trials with a factorial design may assess the effects of multiple interventions in the same population. Factorial trials are carried out under the assumption that the trial interventions have no interactions on outcomes. Here, we present a protocol for a simulation study investigating the consequences of different levels of interactions between the trial interventio

The medial temporal lobe (MTL) is connected to the rest of the brain through two main networks: the anterior-temporal (AT) and the posterior-medial (PM) systems. Given the crucial role of the MTL and networks in the physiopathology of Alzheimer's disease (AD), the present study aimed at (1) investigating whether MTL atrophy propagates specifically within the AT and PM networks, and (2) evaluating

Objective: To examine associations between body mass index (BMI) in early pregnancy and gestational weight gain (GWG) with cardiovascular health in middle age using the ‘Life's Essential 8’ (LE8) concept of the American Heart Association (AHA). Design: Population-based cohort study. Setting: Swedish CardioPulmonary bioImage Study (SCAPIS). Population: A total of 8871 women from SCAPIS were include

Background: The CTLA-4 blocking antibody ipilimumab has demonstrated substantial and durable effects in patients with melanoma. While CTLA-4 therapy, both as monotherapy and in combination with PD-1 targeting therapies, has great potential in many indications, the toxicities of the current treatment regimens may limit their use. Thus, there is a medical need for new CTLA-4 targeting therapies wit

With Euro50 as a convenient telescope laboratory, the Euro50 team has continued development aiming at a European extremely large telescope (ELT). Here, we give a progress report. The needs of science and instrumentation are briefly discussed as is the importance of photometric stability and precision. Results are reported from work on integrated modelling. Details are given concerning point-spread

Zone folded coherent acoustic phonons were generated in a multilayered GaSb/InAs epitaxial heterostructure via rapid heating by femtosecond laser pulses. These phonons were probed by means of ultrafast x-ray diffraction. Phonons both from the fundamental acoustic branch and the first back-folded branch were detected. This represents the first clear evidence for phonon branch folding based directly

Aim: To describe the use of mobility devices among people ageing with spinal cord injury (SCI), with a specific focus on use of powered mobility devices (PMD) and housing accessibility. Method: Data on the use of walking aids (cane, crutch/es or rollator), manual wheelchair and powered wheelchair/scooter were utilized. To describe functional limitations, environmental barriers and the magnitude of

In this work a compact fluorosensor has been built for point-monitoring and imaging applications. The instrument has been applied in fluorescence studies on green vegetation and on malignant tissue. The instrument is based on a violet diode laser, an integrated spectrometer and optical fibers for light delivery and collection of the fluorescence signal. This combination makes the system very compa

Injectable bone substitutes (IBS) based on calcium phosphate (CaP) and/or calcium sulphate (CaS) are used as fillers in bone defects to stimulate bone integration and allow mechanical loading. Two types of IBS, IBS-1 is CaP+20%CaS and IBS-2 is CaS+40% hydroxyapatite, were investigated. The materials were injected into holes in the femur and tibia in rabbits. After 10 weeks the femora were subjecte

Popular Abstract in Swedish (Summary in Swedish) Urininkontinens är ett stort folkhälsoproblem. Ungefär 10 % av kvinnor i 40-årsåldern är drabbade och andelen inkontinenta ökar med ökande ålder. Den vanligaste formen av urininkontinens är så kallad ansträngningsinkontinens med de typiska symptomen urinläckage vid hosta, tunga lyft och gymnastik. I uttalade fall kan dock läckage uppstå redan vid daThe etiology of female stress urinary incontinence (SUI) is unclear. By linking three nationwide medical registries we evaluated maternal and obstetric factors associated with later SUI surgery. Surgery for SUI was strongly associated with vaginal delivery, but not with pregnancy as such. Maternal conditions and interventions during delivery modified the association. Proper evaluation of treatment

We report on the results of our recent theoretical and experimental investigations of a novel, room temperature electrical property of three-terminal ballistic junctions (TBJs). For a symmetric TBJ device, it is found that when finite voltages V-1 and V-r are applied in push-pull fashion, with V-1 = V and V-r = - V. to the left and right branches, the voltage output V-c from the central branch wil

Abstract: Balanced microbiota of the gastrointestinal (GI) tract is important for maintaining health of the host. Altered gut microbiota have been found to be associated with various life-style induced and other intestinal inflammatory diseases. Gut microbiota is viewed as a metabolic organ and considered as new target for therapies. This thesis describes the work on exploring the microbiota of th

Popular Abstract in Swedish Ett antal olika behandlingsformer finns att tillgå vid angrepp av mikroorgansimer, tex antibiotika, samt vid uppkomsten av tumörer, tex strålbehandling och cellgifter. Ett alternativ till dessa traditionella behandlingssätt är att hjälpa kroppens immunförsvar att starta en specifik immunreaktion riktad mot de infekterade cellerna eller mot tumörcellerna. Detta vore en iMajor histocompatibility complex (MHC) class I molecules present antigenic peptides to CD8+ T cells. The peptides are generated by proteasomes in the cytosol, then translocated across the membrane of the endoplasmic reticulum (ER) by the transporter associated with antigen processing (TAP). Only properly assembled class I molecules loaded with high affinity peptides reach the cell surface. The mat

This paper attempts to address the failings of a predominant paradigm in IS research and practice that emphasises technological determinism. This paradigm makes use of a false belief in the power of rationality in organizational decision-making, and a mythology in which organizational actors can be viewed as passive ‘users’ of technology. We wish to create a discussion of the nature and role of pr