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Background: Osteoclasts have been strongly implicated in osteoarthritic cartilage degradation, at least indirectly via bone resorption, and have been shown to degrade cartilage in vitro. The osteoclast resorption processes required to degrade subchondral bone and cartilage-the remodeling of which is important in the osteoarthritic disease process-have not been previously described, although cathepBackground: Osteoclasts have been strongly implicated in osteoarthritic cartilage degradation, at least indirectly via bone resorption, and have been shown to degrade cartilage in vitro. The osteoclast resorption processes required to degrade subchondral bone and cartilage-the remodeling of which is important in the osteoarthritic disease process-have not been previously described, although cathep

Little is known about how gendered understandings of patients can inform professionals’ discretionary actions and decisions to include or exclude in clinical practice. Using Connell's poststructuralist perspectives on gender as an analytic framework, this article aims to investigate how professionals’ articulations of depression are framed by signs of masculinity and femininity, and how these artiLittle is known about how gendered understandings of patients can inform professionals’ discretionary actions and decisions to include or exclude in clinical practice. Using Connell's poststructuralist perspectives on gender as an analytic framework, this article aims to investigate how professionals’ articulations of depression are framed by signs of masculinity and femininity, and how these arti

Presently, there is no single, coherent theory on the causality between cities and economic growth, only a fragmented set of theories. Current patterns and trends for the relationship between cities and economic growth, however, suggest that a full understanding of contemporary processes will not be achieved by relying on the tools of one discipline alone, or by focusing on a single level of analy

Today, in vitro (Latin: in glass) meat researchers strive to overhaul meat production technologies by producing meat outside animal bodies, primarily by culturing cells. In the process, meat should become healthier, more environmentally friendly and kinder to animals. In this article, I scrutinize (and problematize) this promissory discourse by examining the world that proponents envision alongsidToday, in vitro (Latin: in glass) meat researchers strive to overhaul meat production technologies by producing meat outside animal bodies, primarily by culturing cells. In the process, meat should become healthier, more environmentally friendly and kinder to animals. In this article, I scrutinize (and problematize) this promissory discourse by examining the world that proponents envision alongsid

Now, more than ever, we are told that 'authenticity' is an added value that customers want. The objective of this study is to determine what kind of authenticity is relevant to design, and whether it can be used as a standardised procedure to improve product design. In this study industrial designers were interviewed about their views on authenticity. The paper represents the combined result of a

Alla djur uppfattar världen med sina sinnen, vilka ger information till beslut och rörelser. Tyvärr har sinnena begränsningar och när de upphör att ge pålitlig information kommer djurets överlevnad att hotas. Synsinnet till exempel utmanas dagligen, eftersom dess signalstyrka minskar när mörkret faller och ökar igen när solen går upp. I denna avhandling undersökte jag synsystemets anpassningar hosAll animals perceive the world through their senses, which form the basis for their decisions and motor actions. However, when these all-important senses reach their limit and cease to provide reliable information, the animal’s survival is threatened. Among the senses, vision is brought to its limits on a daily basis, because its signal strength is diminished as night falls, and increases again as

AbstractAim The aim of this thesis was to evaluate the treatment and follow-up of patients undergoing hypospadias surgery at the Department of Plastic and Reconstructive Surgery, Skåne University Hospital, Malmö, in an attempt to improve the overall care of these patients. It also aimed to investigate the tissue properties of the urethral plate and deep chordee in hypospadias patients with signifiAbstractAim The aim of this thesis was to evaluate the treatment and follow-up of patients undergoing hypospadias surgery at the Department of Plastic and Reconstructive Surgery, Skåne University Hospital, Malmö, in an attempt to improve the overall care of these patients. It also aimed to investigate the tissue properties of the urethral plate and deep chordee in hypospadias patients with signifi

Detta är en pilotstudie som är utförd av Stefan Larsson, docent i teknik och social förändring vid Lunds universitets internetinstitut (LUii). Studien har utförts under 2016 på uppdrag av Konsumentverket i syfte att peka ut några av de för konsumentintresset viktigaste aspekterna med digitaliseringen. När man studerar digitalisering och dess konsumentbetydelse så ser man ganska snart att dess effe

In the wake of the war and occupation of Iraq, 2003–2004, international legal scholars struggled to understand and adequately describe the event and the law surrounding it. This study takes that situation of uncertainty as its point of departure, and it unfolds through an analysis of the material conditions and linguistic–rhetoric and affective–psychic registers through which the Administrator of In the wake of the war and occupation of Iraq, 2003–2004, international legal scholars struggled to understand and adequately describe the event and the law surrounding it. This study takes that situation of uncertainty as its point of departure, and it unfolds through an analysis of the material conditions and linguistic–rhetoric and affective–psychic registers through which the Administrator of

Vad ska en kursguide eller kurs-PM innehålla? Hur bör ett sådant dokument struktureras? Kursguider har som instruktionsdokument kommit att bli allt mer viktiga som dokument i undervisning på universitet och högskolor och utvecklats till att bli ett semiofficiellt dokument mellan kursplanernas formella nivå och undervisningens mer informella nivå (jfr Robinson 2011, Rowan & Correnti 2009). Ett

Popular Abstract in Swedish Hjärtinfarkt och dess komplikationer är den främsta orsaken till död i västvärlden. Vid en akut hjärtinfarkt stängs blodförsörjningen till en del av hjärtat av pga en blodpropp i ett av hjärtats kranskärl. Den delen av hjärtat som försörjdes av det nu stängda kranskärlet drabbas då av brist på syre och näringsämnen och riskerar att skadas. Skadans storlek på hjärtat berINTRODUCTION: Reperfusion therapy in patients with an ongoing ST-elevation myocardial infarction (STEMI) is to re-establish coronary flow in the epicardial arteries as soon as possible in order to reduce infarct size and associated complications. Hypothermia has in experimental studies been shown to reduce infarct size. Clinical trials, however, have not been able to show this effect, possibly bec

Popular Abstract in Swedish Den globala energianvändningen är idag större än någonsin. Faktum är att den, i takt med världens ständiga utveckling, kommer att fortsätta öka många år framöver. Sättet som energi har producerats på historiskt används dessutom i allra högsta grad fortfarande idag och innebär daglig förbränning av stora mängder organiskt material. Detta resulterar i en ökad koncentratioThis dissertation covers studies of excited state processes in two types of solar energy materials: alternating polyfluorene polymers and their blends with fullerenes in the active layer of plastic solar cells, and bis-tridentate RuII-polypyridyl complexes to be used as sensitizer in systems for artificial photosynthesis. The polymer:fullerene blends were studied by transient absorption and time-

Popular Abstract in Swedish Ett ökade förbrukningen av fossila bränslen kommer att accelerera den globala uppvärmningen med oöverskådlig inverkan på oss och vår miljö. Utvecklingen av alternativa, förnybara och miljömässigt rena energiformer är därför helt essentiell. En möjlig lösning är att skapa artificiell fotosyntes, där solenergi omvandlas till bränsle (till exempel vätgas) i en process där A continuing use of fossil fuels will accelerate global warning and result in severe consequences for the environment and thereby also us. Development of alternative, sustainable and environmentally friendly energy sources is therefore crucial. One approach is to create an artificial photosynthetic system that converts sunshine into fuel (e.g. hydrogen gas) by splitting water molecules. However, i

Popular Abstract in Swedish Enzymer är viktiga ämnen i naturen. Vi talar då och då om att vi förbränner vår mat. Trots detta känner vi oss oftast inte särskilt varma, i alla fall inte så att det bränns. Visst bränner vi vår mat. Socker omvandlas till koldioxid och vatten precis som om vi hade eldat upp det utanför kroppen. Skillnanden är att kroppen omvandlar sockret långsammare och mer kontrollerWith the goal to study the mechanisms of dinuclear metalloenzymes, a new line of synthetic and computational models were prepared and studied. Mixed imidazole and carboxylate multidentate complexes were synthesized to better simulate carboxylate-rich ligand environments. Of the compounds, which showed to be the most useful, were one symmetric and the other one asymmetric and in both cases they wer

Varför vet alla med svenska som modersmål att det heter "en intressant bok" och inte "en bok intressant"? Det beror på vår fantastiska, inre grammatik. Insikten om hur man uttrycker sig på modersmålet är något som barnet lär sig under de första levnadsåren, och redan i treårsåldern behärskar barnet huvuddelen av de omedvetna regler och principer som styr hur meningarna i modersmålet är uppbyggda.

Popular Abstract in Swedish Genom att inta en bärdryck med extra fiber från råg eller havre steg inte blodsockret och insulinnivån lika snabbt jämfört med samma måltid utan fiber i drycken. Dessutom visade ett test två timmar efter havreklimåltiden att avläsningen av insulinrelaterade gener (genuttrycket) hade nedreglerats. Andra gener som påverkades av havremåltiden var kopplade till proteinsynteIt is well established that dietary fibre, especially soluble dietary fibre, has beneficial effects and can prevent diseases associated with the modern lifestyle. This has been explained by the viscous effects of soluble fibre, which can reduce or delay the absorption of carbohydrates and fat in the small intestine, resulting in lower blood concentrations of glucose, insulin and cholesterol. Oats,

Popular Abstract in Swedish Datorer har blivit en viktig del inom den moderna medicinen. Resultat från patientundersökningar såsom bilder, kurvor och mätvärden bearbetas ofta av datorer och presenteras sedan på ett överskådligt sätt för läkaren som grundar sitt svar på bland annat denna information. Denna doktorsavhandling beskriver hur datorn kan hjälpa till vid själva tolkningen av undersökningThe principal purposes of the studies reported in this thesis were to develop new methods to make computerised decision support systems in medicine both more reliable and fully automated. These aims were pursued in the belief that the solution to these problems will lead to an increased clinical use of such systems resulting in benefit to both patient and physician. In the first two studies, meth

Popular Abstract in Swedish I min avhandling har jag studerat marina sedimentkärnor från två kustområden i SE Sverige, dels från Gåsfjärden, strax söder om Västervik i Småland, och dels från kusten utanför Karlskrona i Blekinge. Med syftet att studera hur Östersjöns kustmiljö har förändrats sedan mitten av Holocen (~5000 år sedan). Resultaten visar att kustmiljön har påverkats av flera stressfaktoIn this thesis, I used two coastal sediment sequences from SE Sweden to study how Baltic Sea coastal environment has changed since the mid-Holocene. The results show the coastal environment has been influenced by multi-stressors, such as climate change, shoreline regression and anthropogenic activities. Using the sediment sequence from Karlskrona Bay, past coastal environment between 7300 and 350

Popular Abstract in Swedish Magnetresonanstomografi med faskontrast (PC-MRI) är en icke-invasiv metod för att mäta hastigheter och blodflöden i kroppens större blodkärl, och är ett viktigt verktyg för att diagnosticera och avbilda onormala fysiologiska förlopp. Under de senaste två årtiondena har PC-MRI utvecklats från hastighetsmätningar i enskilda riktningar och snitt till avbildning av komplettIn the last two decades, phase-contrast magnetic resonance imaging (PC-MRI) has evolved from two-dimensional velocity and flow measurements to volumetric, time-resolved depictions of velocity fields (4D PC). The acquisition of time-resolved velocity fields allows flow visualisations that might provide better understanding of the dynamics of the cardiac system. Because 4D PC is increasingly being u