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BACKGROUND: Chronic obstructive pulmonary disease (COPD) has many known dysregulated inflammatory proteins. A disintegrin and metalloproteinase 17 (ADAM17) is a protease that sheds several proteins involved in COPD pathogenesis. The aim was to investigate ADAM17, its phosphorylated form (pADAM17) and its substrates in bronchoalveolar lavage (BAL) and blood from COPD and control subjects. METHODS:

Globally, road traffic accidents (RTAs) remain a major cause of death, particularly among individuals aged 15–30 years. While Sweden has been at the forefront of traffic safety through the Vision Zero initiative, in-hospital management remains crucial in determining RTA outcomes. Drawing on North American evidence suggesting improved survival at trauma centres, the Swedish healthcare system has in

Supersolids formed from dipolar Bose Einstein condensates (BECs) exhibit spontaneous density modulation while maintaining global phase coherence. This state of matter supports gapped amplitude (Higgs) excitations featuring a quadratic dispersion relation. While Higgs modes are typically strongly damped due to coupling with other amplitude and phase modes, imposing an experimentally realistic toroi

ISSUES: Although alcohol consumption is linked to atrial fibrillation (AF), the relationship across different intake levels and between sexes remains unclear. This study presents the first network meta-analysis of prospective cohort studies bringing greater precision to these associations.APPROACH: A systematic review identified five meta-analyses on alcohol and AF risk. From these, 13 cohort stud

Epilepsy is a prevalent neurological disorder characterized by spontaneous recurrent seizures (SRS). Epileptogenesis is a multifaceted pathophysiological process that transforms a normal brain into one prone to chronic seizures. Targeting epileptogenesis is a compelling line of epilepsy therapy. Thus, discovering new drugs that oppose, mitigate, or modify epileptogenesis is a significant challenge

Aims/hypothesis: The aim of this work was to investigate whether baseline uric acid (UA) is associated with future complications among young individuals with newly diagnosed type 1 diabetes. Methods: UA levels were analysed in individuals, aged 15–34 years with newly diagnosed type 1 diabetes, from the nationwide Diabetes Incidence Study in Sweden (DISS) cohort to assess the relationship with macr

The twin transition, which combines green and digital innovation in economic activities, is increasingly central to policy agendas and is also receiving growing attention in regional research. However, accurately mapping green, digital and twin (both green and digital) economic activities across regions remains challenging, particularly due to data constraints. In this study, we advance this resea

Stiffening of tissue is a hallmark of cancer progression, promoting invasive phenotypes through altered cell-extracellular matrix (ECM) interactions. However, how fully formed epithelial structures respond to mechanical cues within their native ECM environment remains poorly understood. Here, using a 3D in situ stiffening hydrogel system that enables modulation of stiffness around mature normal ma

INTRODUCTION: Effective management of chronic breathlessness requires understanding people's activity limitations. This study evaluated the extent to which chronic breathlessness limits people's self-reported everyday activities.METHODS: A web-based, cross-sectional survey (adults ≥18 years). Recruitment was through a marketing research company, stratified to the 2016 Australian Census for key dem

Introduction: The rapid expansion of mobile phone access has enabled low-cost SMS interventions to support adherence to antiretroviral therapy (ART). Although text messaging improves adherence and retention in HIV care, its cost-effectiveness for enhancing quality of life remains uncertain, particularly among adolescents in resource-limited settings. This study evaluated whether SMS reminders impr

The dominant image of judicial authority is emotional detachment; however, judicial work involves emotion. This presents a challenge for researchers to investigate emotions where they are disavowed. Two projects, one in Australia and another in Sweden, use multiple sociological research methods to study judicial experience, expression, and management of emotion. In both projects, observational res

A classical state-preparation device cannot generate states in relative superposition. We introduce classical models in which devices that are individually unable to generate states with relative superposition can be stochastically coordinated to simulate sets of quantum states. These models have natural operational interpretation in prepare-and-measure scenarios and they can account for many non-

Controlled and sequence-selective DNA cleavage plays a crucial role in biomolecular engineering and nucleic acid technologies. Here, we report the development of cerium-coordinated catalytic hydrogel nanoparticles (Ce-CHNP) that exhibit single-strand-selective nuclease activity. Ce-CHNP was synthesized via a one-step polymerization process in which Ce(IV) coordinated with N-hydroxymethyl acrylamid

Statins may have anti-cancer effects against breast cancer, but evidence regarding their influence on the risk of contralateral breast cancer (CBC) remains inconclusive. In this updated study, incorporating a larger sample, extended follow-up, and landmark analyses, we reevaluated the association between post-diagnosis statin use and CBC incidence among women with breast cancer. Utilising the Dani

Objectives Critically ill COVID-19 patients admitted to the intensive care unit (ICU) are at an increased risk of acquiring bacterial bloodstream infections (BSI). We aimed to describe patient characteristics, risk factors, and the microbiological spectrum in blood cultures and evaluate the impact of ICU-acquired BSI on outcomes in a Nordic setting. Methods A prospective multicenter cohort study w

This study presents a modular approach for the synthesis of multifunctional affinity sorbents, facilitating molecular separation via magnetic molecularly imprinted polymers. A magnetic propranolol-imprinted polymer (MIP) nanocomposite with superparamagnetic characteristics was synthesized through precipitation polymerization process coupled with coprecipitation methods. Initially, the propranolol-

Standard quantum measurements are projective. However, the full scope of quantum measurements is represented by positive operator-valued measures (POVMs) and many of these break the limitations of projective measurements as resources in quantum information. It is therefore natural to consider how accurately an experimenter with access only to projective measurements and classical processing can si

Growth and immune development—fundamental parts of any organism's ontogeny—depend critically on nutrient availability, particularly on essential amino acids that support protein synthesis and physiological processes. However, environmental variation can reduce prey diversity and nutrient quality, producing suboptimal diets that lack essential amino acids, potentially constraining development. In t

The Bcl-2 family of proteins governs mitochondrial outer membrane (MOM) permeabilization, a critical step in apoptosis that is dysfunctional in many cancers. Although cellular studies have long implicated direct interactions between the pore-forming apoptotic Bax protein and its opponent, the antiapoptotic Bcl-2 protein in apoptosis regulation, the underlying basic principles behind this control r