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This is the protocol for a Campbell systematic review. The objectives are as follows: to assess the efficacy of interventions aiming to improve outdoor mobility for people with disability and to explore if the efficacy varies between different populations and different intervention components.

Background: Alpha-1 antitrypsin deficiency (AATD) is a rare disease that is associated with an increased risk of pulmonary emphysema. The European AATD Research Collaboration (EARCO) international registry was founded with the objective of characterising the individuals with AATD and investigating their natural history. Methods: The EARCO registry is an international, observational and prospective

BackgroundRisky sexual behavior is a public health challenge that significantly affects young people’s health and well-being in Sweden and throughout the world. Moreover, poor mental health, anxiety and depression among adolescents and young adults have increased in recent years. However, although hypothesized, the associations between general mental health and risky sexual behavior among young ad

Aims: Preclinical and human studies suggest that a social partner's genotype may be associated with addiction-related outcomes. This study measured whether spousal genetic makeup is associated with risk of developing drug use disorder (DUD) during marriage and whether the risk associated with a spouse's genotype could be disentangled from potentially confounding rearing environmental effects. Desi

The bowing of the energy of the three lowest band-to-band transitions in β−(AlxGa1−x)2O3 alloys is resolved using a combined density-functional theory (DFT) and generalized spectroscopic ellipsometry approach. The DFT calculations of the electronic band structure of both β−Ga2O3 and θ−Al2O3 allow the linear portion of the energy shift in the alloys to be extracted, and provide a method for quant

Hydroxyapatite (HA) has been widely used as a bone substitute and more recently as a carrier for local delivery of bone targeted drugs. Majority of the approved HA based biomaterials and drug carriers comprise of micrometer sized particulate HA (mHA) or granules and can therefore only be used for extracellular drug release. This shortcoming could be overcome with the use of cell penetrating HA nan

Subgap states are responsible for the low-bias transport features of hybrid superconducting-semiconducting devices. Here we analyze the local and nonlocal differential conductance of Coulomb-blockaded multiterminal superconducting islands that host subgap states with different spatial structures. The emerging patterns of their transport spectroscopy are used to characterize the possible topologica

Small-angle neutron scattering (SANS) experiments were conducted on cyclic and linear polymers of racemic and l-lactides (PLA) with the goal of comparing chain configurations, scaling, and effective polymer–solvent interactions of the two topologies in acetone-d6 and THF-d8. There are limited reports of SANS results on cyclic polymers due to the lack of substantial development in the field until

Head and neck skin cancer surgery using a full thickness skin graft is a common procedure. Evidence concerning the effects of perioperative antithrombotic treatment on complications is limited. The aim of this study was to evaluate whether perioperative antithrombotic treatment is associated with risk of necrosis, bleeding or infection after full thickness skin graft surgery. Retrospective single-

BACKGROUND: Inherited CDKN2A mutation is a strong risk factor for cutaneous melanoma. Moreover, carriers have been found to have poor melanoma-specific survival. In this study, responses to novel immunotherapy agents in CDKN2A mutation carriers with metastatic melanoma were evaluated.METHODS: CDKN2A mutation carriers that have developed metastatic melanoma and undergone immunotherapy treatments we

Context: Pulmonary arterial hypertension (PAH) affects people of all ages and is associated with poor prognosis. Chronic breathlessness affects almost all people with PAH. Objectives: This randomized, placebo-controlled, double-blind, crossover study aimed to evaluate the effects of regular, low-dose, extended-release (ER) morphine for PAH-associated chronic breathlessness. Methods: Participants w

Objective: To determine the frequency, characteristics, and outcomes of cerebrovascular events (CerVEs), as well as clinical and autoantibody associations in a multiethnic/racial inception cohort of patients with systemic lupus erythematosus (SLE). Methods: A total of 1,826 patients were assessed annually for 19 neuropsychiatric (NP) events, including 5 types of CerVEs: 1) stroke, 2) transient isc

Floods constitute a major problem that cross geopolitical, administrative, and sectoral boundaries, and must as such be jointly governed by a web of actors. The patterns of social relations among these actors are fundamental for society's capacity to mitigate flood risk. The purpose of this study is to contribute to our understanding of flood risk governance by investigating the social organizatio

Sweden has witnessed a significant increase in the rate of firearm-related homicide. We therefore aimed to study the characteristics of individuals suspected of homicide, attempted homicide, preparation to commit homicide as well as conspiracy to commit homicide with a firearm in Sweden. By using information from different registers, suspected individuals between 2000 and 2017 and aged 15 to 60 we

Background: Digital breast tomosynthesis (DBT) improves breast cancer (BC) detection compared to mammography, however, it is unknown whether this reduces interval cancer rate (ICR) at follow-up. Methods: Using individual participant data (IPD) from DBT screening studies (identified via periodic literature searches July 2016 to November 2019) we performed an IPD meta-analysis. We estimated ICR for