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Introduction: When a child is diagnosed with Type 1 diabetes, it involves extensive lifestyle changes for the whole family. There is limited knowledge of the impact the initial care has for children and parents over time. The aim was to compare children’s diabetes-specific health-related quality of life (HRQOL) in hospital-based care and hospital-based home care (HBHC), 12 and 24 months after the

Objective The aim of this study was to estimate the rate of fetal loss in dichorionic (DC) and monochorionic (MC) twin pregnancies stratified according to zygosity and method of conception. Methods In a prospective multicenter observational study women with a twin pregnancy bad an ultrasound scan before 14 + 6 weeks' gestation in order to determine chorionicity. The fetal loss rate, the perinatal,

Popular Abstract in Swedish Normal hjärnaktivitet är beroende på en delikat balans mellan inhibitorisk och excitatorisk nervcellssignallering. Om denna balans störs och lutar mer åt en ökad excitering uppstår epileptiska anfall. Ungefär 1 % av befolkningen i västvärldens drabbas av epilepsi, framförallt av temporallobs-epilepsi (TLE) vilket är den vanligast förekommande formen av epilepsi bland vuTemporal lobe epilepsy (TLE) is the most common form of epilepsy among adult patients, and the most problematic one as seizures cannot be controlled by currently available drugs in 30 % of patients. Gene therapy based on overexpression of endogenous anti-epileptic agents such as the neuropeptide galanin and the glial cell line-derived neurotrophic factor (GDNF) represents a promising new approach

Congenital haemophilia A and B are genetic disorders affecting factor VIII and factor IX production, respectively. Factor replacement is the only effective treatment for these deficiencies, but a patient's immune system can develop inhibitory antibodies which bind and interfere with the function of the replaced factor in a variety of ways. The main treatment goal for patients with inhibitors is to

OBJECTIVE: The aim of this study was to explore the associations between inadequate glycemic control of diabetes and psychological, anthropometric and life style variables in a population based cohort of type 1 diabetes patients. DESIGN: Cross-sectional study. METHODS: In this study 292 patients with type 1 diabetes participated, age 18-59 years. Psychological data were assessed by self-report ins

We investigate the CCN activity of freshly emitted biomass burning particles and their hygroscopic growth at a relative humidity (RH) of 85%. The particles were produced in the Mainz combustion laboratory by controlled burning of various wood types. The water uptake at sub- and supersaturations is parameterized by the hygroscopicity parameter, κ (c.f. Petters and Kreidenweis, 2007). For the wood b

Popular Abstract in Swedish När ett barn föds före graviditetsvecka 30 är andningsinsufficiens eller på engelska kallad respiratory distress syndrome (RDS) ett av de stora kliniska problemen som barnläkaren står inför. Redan på 1920-talet förstod man att det måste finnas ett ytspänningsnedsättande ämne i lungorna och på 1950-talet fann man att för tidigt födda (prematura) barn med RDS hade brist pUsing an animal model, the thesis explores how the initial ventilation of the lungs, and surfactant therapy, should best be managed after premature birth. Material and measurements: The studies were made in newborn lambs delivered by cesarean section. Spread of exogenous surfactant was analysed by mixing it with technetium-labelled macroaggregated human serum albumin and imaging the radioactivity

Interaction of mono- and disaccharides, polysaccharide particles and yeast cells with boronate-containing copolymers (BCC) of N-acryloyl-m-aminophenylboronic acid (NAAPBA) with NN-dimethylacrylamide (DMAA) or N-isopropylacrylamide (NIPAM) was studied. The binding of saccharides to BCC of NIPAM resulted in a shift of its phase transition temperature (Delta T-p), which provided a quantitative measur

Objective. To study degree of blood pressure (BP) control in primary healthcare (PHC) treated hypertensive patients in relation to sex, age, drug treatment, and concomitant diseases. Design. Random sample of patients with hypertension. Setting. Ten PHC centres in the Region of Skane, Sweden. Subjects. All the 30- to 95-year-old patients with hypertension who during the period 12 September to 24 Se

BACKGROUND AND AIMS: Leukocyte recruitment is a key feature in ischemia-reperfusion (I/R)-induced tissue injury. The aim of the present study was to investigate the effect of Rho-kinase inhibition on I/R-provoked leukocyte recruitment in the colon. METHODS: C57BL/6 mice were subjected to 30 min of ischemia by clamping of the superior mesenteric artery followed by 120 min of reperfusion. Intraperit

Phosphodiesterase type 3B (PDE3B) has been shown to be activated and phosphorylated in response to insulin and hormones that increase cAMP. In order to study serine/threonine protein phosphatases involved in the regulation of rat adipocyte PDE3B, we investigated the phosphorylation and activation of PDE3B in vivo in response to phosphatase inhibitors and the dephosphorylation and deactivation of P

We have investigated the poorly-understood origin of nitrogen in the early Galaxy by determining N abundances from the NH band at 336 nm in 35 extremely metal-poor halo giants, with carbon and oxygen abundances from Cayrel et al. (2004, A&A, 416, 1117), using high-quality ESO VLT/UVES spectra (30 of our 35 stars are in the range -4.1 <[Fe/H] < -2.7 and 22 stars have [Fe/H] < -3.0). N abundance

Superporous agarose beads contain two sets of pores, diffusion pores and so-called superpores or flow pores, in which the chromatographic flow can transport substances to the interior of each individual bead [Gustavsson and Larsson, J. Chromatogr. A 734 (1996) 231]. The existence of pore flow may be proven indirectly by the chromatographic performance of beads but it has never been directly demons

Secondary metabolites produced by fungi and bacteria are among the potential agents that contribute to adverse health effects observed in occupants of buildings affected by moisture damage, dampness and associated microbial growth. However, few attempts have been made to assess the occurrence of these compounds in relation to moisture damage and dampness in buildings. This study conducted in the c

Popular Abstract in Swedish Antagandet att människor är förmögna att kontrollera och avsiktligt glömma oönskade minnen har varit kontroversiellt allt sedan Freud (1915/2000) först antog den typen av psykologisk process. Men aktuell experimentell forskning ger ökat belägg för att avsiktligt undertryckande av oönskade minnen faktiskt kan leda till senare glömska (cf. Levy & Anderson, 2002). ResuForgetting can be highly functional when unwanted or irrelevant memory representations interfere with cognitive or motivational goals. Current theory assumes that forgetting can be brought about by the intentional or unintentional inhibition of interfering memory representations. In four studies, the present thesis investigated this claim by employing behavioral testing, and neuroimaging methods b

Policy-makers in the European Union (EU) have increasingly emphasised public procurement as an instrument that can be used to stimulate innovation. These developments reflect and respond to a growing concern among EU member states and regions about how to maintain competitive advantage in an economic environment increasingly subject to global competition The Lisbon goals set for the EU in 2000 req

Background: The Tau PET ligand 18F-AV1451 has been shown to reliably detect paired helical filaments of tau in Alzheimer's disease, but it is not yet known whether it binds to the tau aggregates present in patients with mutations in the gene (MAPT) coding for the tau protein. Further, no study has yet compared the cerebral retention of 18F -AV1451 with the tau aggregates revealed using neuropathol

Purpose: High plasma copeptin, a marker of vasopressin, predicts diabetes mellitus. We tested if copeptin could be suppressed by increased water intake in healthy individuals, and if a water-induced change in copeptin was accompanied by altered concentrations of glucose, insulin or glucagon. Methods: Thirty-nine healthy individuals underwent, in random order, 1 week of high water intake (3 L/day o

It is widely recognised that the two major challenges of the 21st century are climate change and poverty. The building sector is responsible for over a third of all global carbon dioxide emissions. At the same time, we see vastly overcrowded and rapidly growing informal settlements in developing countries, where people lack the basic right to decent shelter. This is simply not sustainable and forc