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Acute pancreatitis - Cellular response and dynamic inflammatory changes

Popular Abstract in Swedish Akut pankreatit (bukspottkörtelinflammation) drabbar årligen cirka 300 individer per miljon invånare i Sverige. Dödligheten ligger totalt på cirka 4-7 % och betydligt högre, cirka 20 %, vid svår nekrotiserande pankreatit. Mortaliteten är vanligen associerad med multipel organsvikt och korrelerad till storleken på det inflammatoriska svaret. Underliggande mekanismer för Acute pancreatitis (AP) is a common disorder where underlying mechanisms for the local initiating events in the pancreas, the systemic dissemination of the inflammatory response and the remote organ dysfunction still are unclear. The aim of the present study was to further characterize the dynamics and sequence of the immune response in AP, and to determine the cellular origin of the initiating ev

Removal of Water-Soluble Extractives Improves the Enzymatic Digestibility of Steam-Pretreated Softwood Barks

Softwood bark contains a large amounts of extractives—i.e., soluble lipophilic (such as resin acids) and hydrophilic components (phenolic compounds, stilbenes). The effects of the partial removal of water-soluble extractives before acid-catalyzed steam pretreatment on enzymatic digestibility were assessed for two softwood barks—Norway spruce and Scots pine. A simple hot water extraction step remov

THE USE OF META-ETHNOGRAPHY TO GUIDE IMPLEMENTATION STRATEGIES

BackgroundFor implementation of new assessment strategies, an evidence-informed approach is desired. Thus, the assessment methodshould be supported by current evidence, and similarly the implementation process could be informed through research.Implementation research can be done using various approaches and research methods. However, it seems that interviewstudies are an important source of infor

A numerical human brain phantom for dynamic glucose-enhanced (DGE) MRI : On the influence of head motion at 3T

PURPOSE: Dynamic glucose-enhanced (DGE) MRI relates to a group of exchange-based MRI techniques where the uptake of glucose analogues is studied dynamically. However, motion artifacts can be mistaken for true DGE effects, while motion correction may alter true signal effects. The aim was to design a numerical human brain phantom to simulate a realistic DGE MRI protocol at 3T that can be used to as

Degradation of the microbicide 2-(thiocyanomethylthio) benzothiazole by direct photolysis

Microbicides in the leather industries are employed to avoid the biodeterioration of the hides by microorganisms. This problem may lead to harmful characteristics to the end product such as stains, roughness and decrease mechanical properties of leather. Therefore, microbicides like the 2-(thiocyanomethylthio) benzothiazole (TMCTB) are applied in distinct steps of the tanning process as alternativ

Adsorption of phenanthrene on Al (oxy) hydroxides formed under the influence of tannic acid

Although there has been substantial research done on adsorption of metals/metalloids by Al (oxy)hydroxides, little is known regarding the adsorption of polyaromatic hydrocarbons (PAHs) on Al (oxy)hydroxides, especially those formed in the presence of organic acid. This paper investigated the adsorption of phenanthrene on Al (oxy)hydroxides formed with initial tannate/Al molar ratios (MRs) 0, 0.001

Role of Adsorption Structures of Zn-Porphyrin on TiO2 in Dye-Sensitized Solar Cells Studied by Sum Frequency Generation Vibrational Spectroscopy and Ultrafast Spectroscopy

Several Zn-porphyrin (ZnP) derivatives were designed to build highly efficient dye-sensitized solar cells (DSC). It was found that solar cell efficiencies normalized for surface coverage (eta(rel)) are affected by the molecular spacer connecting the porphyrin core to the TiO2 surface, the sensitization conditions (solvent and time), and, to a lesser extent, the nature of the terminal group of the

High catechins/low caffeine powder from green tea leaves by pressurized liquid extraction and supercritical antisolvent precipitation

This paper reports a method to produce a solvent-free extract from green tea leaves with high content of catechins and low content of caffeine, in two steps and using only "green" solvents. The method is based on the pressurized liquid extraction (PLE) of the green tea leaves using ethyl lactate as solvent, followed by a selective precipitation procedure using the supercritical carbon dioxide (SCC

Phosphatidylethanol affects inositol 1,4,5-trisphosphate levels in NG108-15 neuroblastoma x glioma hybrid cells

Phosphatidylethanol is formed by phospholipase D in animal cells exposed to ethanol. Previous reports have demonstrated that the degradation of phosphatidylethanol is slow, indicating that this lipid may be present in the cells after ethanol itself has disappeared. Accumulation of an abnormal alcohol metabolite may influence cellular functions. In the present study, cultivation of NG108-15 neurobl

On the induction of inflammatory reactions by Streptococcus pyogenes

Streptococcus pyogenes is an important human pathogen that causes significant morbidity and mortality worldwide. In order to successfully infect the human host, S. pyogenes is equipped with tools that modulate the human immune defence. The present thesis explores how different streptococcal proteins interfere with innate immunity, adaptive immunity, and blood coagulation. M protein is a surface-b

Self-Knowledge/Self-Regulation/Self-Control: A Ubiquitous Computing Perspective

This thesis is about self-knowledge, self-regulation and self-control. All three of these terms are easily understandable, and apply to situations in our daily lives (like misjudging one’s own competence at retiling the bathroom floor, or feeling the anxiety and thrill of doing unsupervised work, or guiltily hitting the snooze-button for the fifth time, and missing half a day of school). The five

Relaxation kinetics of an L-3 (sponge) phase

The kinetic response of an L-3 (sponge) phase formed in the C12E5-n-decane-brine system is studied using the Joule-heating temperature jump (JHTJ) technique. The equilibrium state of the spongelike membrane is instantaneously perturbed, and the kinetic response is monitored using a multi-angle light scattering setup. These measurements yield a time-dependent scattering intensity as a function of t

Dynamic Solid Oxide Fuel Cell Modelling for Non-steady State Simulation of System Applications

Most of the world's energy generation is based on fossil fuels such as coal and oil, which already today but even more in the future, will cause various problems. One issue is their limited availability, which stands in conflict to the increasing global energy consumption. Another problem is the carbon dioxide generation caused by burning fossil fuels for energy production, and is thought to be on

On the Machinability of Ductile and Strain Hardening Materials - Models and Methods for Analyzing Machinability

Popular Abstract in Swedish Allteftersom kraven på kvalité och prestanda hos dagens produkter ökar används alltmer avancerade material som en del av modern produktion. Problemet som uppstår är dock att dessa material ställer nya krav på tillverkningsprocessen och då inte minst vid skärande bearbetning. Trots att en betydande mängd forskning redan har publicerats vad gäller skärande bearbetning av As quality and performance demands on today’s products increases, more and more advanced materials are being used during modern production. The problem is however that this in turn place new demands on the machining processes utilized. Even though a significant amount of research has been published on the machining of these materials knowledge is still limited in several crucial areas. A problem w

Butterfly Diversity and Dispersal in Fragmented Grasslands

Popular Abstract in Swedish Under de senaste decennierna har utbredningen och förekomsten i av många arter av fåglar, växter och insekter knutna till jordbrukslandskap på olika håll i Europa minskat på grund av jordbrukets rationalisering och intensifiering. För att motverka dessa negativa trender måste man ha kännedom om den relativa betydelsen av lokala och regionala ekologiska processer för popDuring the last decades, the distribution and abundance of many European species of birds, plants and insects in agricultural landscapes have declined due to agricultural intensification. To be able to mitigate these declines, it is essential to know the relative importance on local and regional ecological processes on population persistence and patterns of species richness. I have studied the ef

Functional Models for Non-heme Mononuclear Iron Oxygenases

Popular Abstract in Swedish Denna avhandling beskriver vissa funktionella syntetiska modeller av non-hem mononukleära järn oxygenas-enzymer. Sådana enzymer katalyserar ett brett spektrum av oxidationsreaktioner av biologisk relevans, som utnyttjar molekylärt syre. Dessa reaktioner utförs i regio- och stereoselektivt sätt och med hög verkningsgrad. Föreslås oxidationsreaktionerna ske via mellan hög

Structural Studies Of Materials Using Time-Resolved X-ray Diffraction

This work consisted of the application of X-ray diffraction methods to the study of ultrafast phenomena in various materials. Since the X-ray pulses generated from the bending magnet at the MAX II ring, where most of the experimental work was conducted, have a duration of the order of 300 ps, they can not be used directly as probe pulses in experiments where higher temporal resolution is required.