Filtyp
The key step in the reaction mechanism of multicopper oxidases (MCOs)-the cleavage of the O-O bond in O-2-has been investigated using combined quantum mechanical and molecular mechanical (QM/MM) methods. This process represents a reaction pathway from the peroxy intermediate after it accepts one electron from the nearby type-1 Cu site to the experimentally-observed native intermediate, which is th
Background: One key aspect of person-centredness is striving to understand both the patients' experiences and behaviours from their perspective. These aspects are precisely those that staff in dementia care highlight as causing them most difficulty because the people in their care have major problems expressing themselves. There is thus a need to develop a method to help the staff to achieve inter
Under 1680-talet trädde Sophia Elisabet Brenner fram som poet och blev snart känd och uppskattad för sina dikter vid olika tillfällen i livet. Tillfällesdiktningen var en flexibel genre som gav henne möjligheten att resonera om tidens aktuella frågor, till exempel kvinnans ställning i äktenskap och samhälle eller värderingen av det som var gammalt och fornt och det som var nytt. Hennes rykte spred
Purpose of this paper The purpose of this paper is to present a comparative case study of the procedures and guiding principles in the packaging selection practice of two international companies. Design/methodology/approach A qualitative case study with an inductive approach was conducted. The data was collected through semi-structured interviews, documentation, and field visits. Findings Th
Popular Abstract in Swedish Bakgrund Streptococcus pyogenes, eller grupp A streptokocker, är en av de vanligaste sjukdomsframkallande bakterierna hos människan. De orsakar ofta relativt harmlösa och lättbehandlade ytliga infektioner i hals (halsfluss) och hud (svinkoppor) men kan också ge djupare och livshotande infektioner. Dessutom förekommer följdsjukdomar efter infektioner med grupp A streptoPathogenic bacteria often produce potent proteases capable of destroying host tissue thereby providing the bacteria with tools for spreading and nutrient access. This thesis describes how group A, C and G streptococci can acquire surface bound protease activity through an alternative mechanism, namely by binding and activation of the human protease precursor plasminogen. Group A streptococci of c
This thesis is about understandings of understanding and has developed from previous research on study skill and conceptions of learning among participants in various forms of education. The purpose was to investigate understandings of understanding as a phenomenon and the significance of understanding of understanding for learning. The investigation involved 101 persons between 12 and 75 years of
Intergovernmental collaboration in Big Science has been an important resource for European science since the 1950s, as a means to compete on global level. But interestingly, collaboration in (basic) science has traditionally been left outside of the political integration work of the European Community/Union, which has resulted in a cluttered policy field and a situation where European Big Science
Popular Abstract in Swedish Avhandlingen består av tre separata papper. De är alla empiriska studier som undersöker hur fragmentering av produktionsprocesser och globala utbudskedjor har påverkat internationell handel. Den första studien fokuserar på hur privata standarder i den alltmer globaliserade livsmedelsindustrin påverkar företags importbeteende. Genom att ge en kvalitetsförsäkran kan cert
Various biological problems such as disease mechanisms, drug development and toxicological studies motivated the introduction of cellular models that today also represent an alternative for reducing the use of animals in controversial medical and pharmaceutical experiments. Cells are complex matrices where several processes occur simultaneously. Because of this, analytical methods with specific p
Background. Although the topic of pain among older people has received increasing interest, little is still known about how pain is experienced or handled by those who no longer manage independently but depend on professionals for help with daily living. Developing pain management for older people requires such knowledge. Aim. To explore sense of self, sense of pain, daily living with pain, sense
Ecosystem phenology plays an important role in carbon exchange processes and can be derived from continuous records of carbon dioxide (CO2) exchange data. In this study we examined the potential use of phenological indices for characterizing cumulative annual CO2 exchange in four contrasting northern peatland ecosystems. We used the approach of Jonsson and Eklundh (2004) to derive a set of phenolo
Sphingosine 1-phosphate (S1P) is a signalling sphingolipid affecting multiple cellular functions of vascular and immune systems. It circulates at submicromolar levels bound to HDL-associated apolipoprotein M (apoM) or to albumin. S1P in blood is mainly produced by platelets and erythrocytes, making blood sampling for S1P quantification delicate. Standardisation of sampling is thereby of great impo
The doubly magic nucleus 100Sn represents a crucial test for the nuclear shell model, which is a widely used model for a quantitative description of nuclei. Excited states in 100Sn are experimentally not accessible with present day techniques, but it is possible to gain insight into its structure by studying the properties of excited states of neighboring nuclei. These nuclei
Despite rapid development, modern graphics hardware is still much too slow to render photo-realistic images in real time, and it will most likely remain so if we rely only on yearly growth in hardware performance. Therefore, better algorithms are constantly needed in order to advance the field. In the first part of this thesis, we present new algorithms for hardware rasterization. We investigate
When a speaker spontaneously draws, what is the correlation between visual focus movements over the drawing and focus movements in the discourse? How is the listener's internal image constructed from the spoken discourse? We studied these questions empirically by transcribing spoken language data into intonation units and comparing them to events in the drawing. In our analysis, we employed an ima
Multi-target aptamer selection, known as multiplex systematic evolution of ligands by exponential enrichment (SELEX), is rapidly drawing interest because of its potential to enable high-speed, high-throughput aptamer selection. The parallelization of chemical processes by integrating microfluidic unit operations is a key strategy for developing a multiplex SELEX process. One of the potential probl
The free and open source software tool ADAPT (A Diversely Applicable Parameter Identification Tool) for the inverse parameter identification of constitutive material models is presented and applied in combination with Finite Element (FE) simulations. Different types of input data, namely integral data such as forces and field data such as displacement and strain fields, are considered within a mul
Environmental impact and security of supply has fuelled a shift in the power mix of power systems today. Traditionally used fossil fuel gives more and more space to the development of renewables in an effort to comply with strict international standards regarding CO2 emissions and secure energy supply. Wide geographical spread of renewable resources indicates that HVDC technology is most suitable
This thesis studies the concept of calculation of Value-at-Risk and Ex- pected Shortfall when the choice of model is uncertain. The method used for solving the problem is chosen to be Bayesian Model Averaging, using this method will reduce the model risk by taking several models into ac- count. Monte Carlo methods are used to perform the model averaging and the calculation of the risk measurements
