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INTRODUCTION: Genetic deficiency of factor XI is associated with a reduced risk of ischemic stroke. Asundexian is a direct inhibitor of activated factor XIa (FXIa) with a low risk of bleeding in early trials. We seek to determine its efficacy and safety combined with antiplatelet therapy for prevention of ischemic stroke. PATIENTS AND METHODS: Oral faCtor Eleven A iNhibitor asundexian as novel ant
This paper summarized the efforts performed to understand decay heat estimation from existing spent nuclear fuel (SNF), under the auspices of the Working Party on Nuclear Criticality Safety (WPNCS) of the OECD Nuclear Energy Agency. Needs for precise estimations are related to safety, cost, and optimization of SNF handling, storage, and repository. The physical origins of decay heat (a more correc
BackgroundThe Job Demand–Control–Support (JD-C-S) model evaluates how psychosocial work factors affect health and performance. We examined how demographics, job title, and experience influence demand, control, and support among Ghanaian pharmacy staff.MethodsA cross-sectional survey of pharmacy personnel from Tamale and Sagnerigu was conducted using the JD-C-S questionnaire. Demand and control ite
Introduction Systemic inflammation is postulated to mediate heat stroke and heat-related organ injury, yet acute inflammatory responses among heat-stressed workers remains poorly understood. We aimed to describe neutrophil mobilisation and potential release of DNA during heat stress in multiple hot occupational settings and a controlled experimental setting. Methods Neutrophil:lymphocyte ratio (NL
Democracies face a crisis of public reason grounded in a disintegration of shared epistemic ground and amplified by digital polarisation and AI-mediated disinformation. Current pedagogy, focused on deconstructive critique or fact-checking skills, fails to address how algorithmic systems engineer plausibility at scale. Higher education must cultivate discerning judgement alongside critique. Drawing
Objectives: Panax ginseng (P. ginseng, C.A. Meyer) is suggested to improve blood glucose regulation, but evidence remains inconsistent. We examined whether consuming P. ginseng as a preload before a carbohydrate-rich meal modulates postprandial glucose and insulin responses. Methods: In a randomized, double-blind, crossover trial, 22 healthy middle-aged adults consumed P. ginseng tablets containin
BACKGROUND AND OBJECTIVE: Achieving adequate concentrations of beta-lactam antibiotics in patients with severe infections is challenging, and therefore therapeutic drug monitoring (TDM) would be optimal for guiding beta-lactam dosing, but is often limited by availability. UV/VIS spectrophotometry can quantify drug levels in saline, and if those levels truly reflect plasma concentrations, it could
BACKGROUND/AIM: Determining the causation of an injury in living individuals is a key task for forensic pathologists. However, little is known about sex-based differences in injury characteristics. The study aims to examine sex-based differences in single stab injuries to the trunk among assault survivors, to potentially identify injury patterns that could aid forensic assessment and help in the m
BACKGROUND: Early HIV diagnosis allows timely interventions to control HIV transmission. We have determined the proportion of recent infections among people living with HIV (PLHIV) enrolling to care in Ethiopia and identified factors associated with recent infection. METHODS: Participants (aged ≥ 15 years) newly enrolled in HIV care were recruited from urban clinics in central Ethiopia (2022-2024)
Literature reviews lay the foundation for almost every academic research project, and sometimes are a scholarly contribution in its own right. To increase rigor and credibility the findings have to be valid and reliable just as in any other type of research. This paper summarizes recent methodological developments in the application systematic literature reviews in supply chain management. It anal
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